Learn how Monolith helps you facilitate the rational design of your PROTACs.
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![Virtual Monolith X Demo: Free-in-solution affinity measurements with minimal sample consumption](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fcontent.cdntwrk.com%2Ffiles%2FaHViPTg2NTQ5JmNtZD1pdGVtZWRpdG9yaW1hZ2UmZmlsZW5hbWU9aXRlbWVkaXRvcmltYWdlXzY2MWQwYmY0NDY0NWYucG5nJnZlcnNpb249MDAwMCZzaWc9MWE5ZWVmNTExN2FmYmNlMzZkNDlhZGQxNTJkYWE5OWQ%25253D&size=1&version=1713179833&sig=3b3b7101029cc896863d7afe24d7f71b&default=hubs%2Ftilebg-videos.jpg)
The tool you choose to measure affinities should tackle a diverse range of targets and ligands that come your way — such as GPCRs, IDPs, or cancer-related proteins. And, you should get data that help
![The power of Monolith X for Characterizing GPCRs: Accelerating Binding Affinity Measurements](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fcontent.cdntwrk.com%2Ffiles%2FaHViPTg2NTQ5JmNtZD1pdGVtZWRpdG9yaW1hZ2UmZmlsZW5hbWU9aXRlbWVkaXRvcmltYWdlXzY1ZTA4YjAzMDljOTYucG5nJnZlcnNpb249MDAwMCZzaWc9OTkxNGVhMzIxZTAyMjk5YmY4YzQ1Yjc3N2E0YzBmZTM%25253D&size=1&version=1715959201&sig=281cc151c7988000618f90ac9d4511df&default=hubs%2Ftilebg-videos.jpg)
To understand signaling pathways, Spectral Shift technology allows for accurate bindings affinity measurements of membrane proteins like GPCRs in close to native conditions.
![Three things we took away from attending Drug Discovery Chemistry in 2024](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fnanotempertech.com%2Fwp-content%2Fuploads%2F2024%2F04%2FAerial-view-of-Coronado-Bridge-in-San-Diego-bay-in-southern-California-scaled.jpeg&size=1&version=1712849135&sig=0432c0ca2517a3081870c498583bcd85&default=hubs%2Ftilebg-blogs.jpg)
Drug Discovery Chemistry is an annual event that focuses solely on early drug discovery, where scientists from around the world gather to showcase their research and participate in thoughtful...
![NanoTemper announces Monolith X with breakthrough Spectral Shift technology, enabling affinity measurements where other methods fail](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fnanotempertech.com%2Fwp-content%2Fuploads%2F2022%2F09%2Fmonolith-x-featured.png&size=1&version=1665679078&sig=288c27d48bab64c3b10ebf0b41667ba6&default=hubs%2Ftilebg-blogs.jpg)
NanoTemper Technologies introduced Monolith X, adding breakthrough Spectral Shift technology to their top-selling Monolith product line.
![Introducing Monolith X - the only way to get binding affinities in solution using very minimal sample](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fcontent.cdntwrk.com%2Ffiles%2FaHViPTg2NTQ5JmNtZD1pdGVtZWRpdG9yaW1hZ2UmZmlsZW5hbWU9aXRlbWVkaXRvcmltYWdlXzYzMjhmNzlhMTQyOWQucG5nJnZlcnNpb249MDAwMCZzaWc9ZDEwMzAyYjRiYzZlMWU1ZDhhYjI4YTM3NTJmNjk0NDM%25253D&size=1&version=1665679078&sig=173223c3f58eff7c5ec985fb01f8d185&default=hubs%2Ftilebg-videos.jpg)
![NanoTemper’s Monolith wins top global design award: Red Dot Award](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fnanotempertech.com%2Fwp-content%2Fuploads%2F2021%2F07%2FRed-Dot-Featured-Image-1.png&size=1&version=1720526038&sig=ac4f61af1435c412041c8c354b150ddc&default=hubs%2Ftilebg-blogs.jpg)
NanoTemper’s newest Monolith instrument has been awarded the Red Dot Award, an internationally recognized seal of excellence in design. Both bold aesthetics and user-friendly design have always...
![10 terms to help you more easily understand targeted protein degradation](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fnanotempertech.com%2Fwp-content%2Fuploads%2F2022%2F03%2Fchalk-Featured-Image.png&size=1&version=1720526038&sig=b3b65cc702b067100ecb1cf985629571&default=hubs%2Ftilebg-blogs.jpg)
If you’re new to the world of TPD or you’re trying to keep up with all developments in this fast-moving field, here are some terms and definitions that will help you.
![How to study molecular interactions of membrane proteins without compromising their native structure](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fcontent.cdntwrk.com%2Ffiles%2FaHViPTg2NTQ5JmNtZD1pdGVtZWRpdG9yaW1hZ2UmZmlsZW5hbWU9aXRlbWVkaXRvcmltYWdlXzYxMTU5YWZiMjE4ZDgucG5nJnZlcnNpb249MDAwMCZzaWc9ODgzNzlmMzFjYTcxYjI5ZDQ0YjlmYWU2MTdjZWI1NzE%25253D&size=1&version=1665679078&sig=76dc416ceabfcde4a70734ab2ed32923&default=hubs%2Ftilebg-videos.jpg)
The desire to use technology that allows you to study membrane proteins in close-to-native conditions is specifically important when it comes to interaction measurements. It’s always a question how mu
![Improve your protein degrader design with new ways to discover E3 ligase ligands](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fcontent.cdntwrk.com%2Ffiles%2FaHViPTg2NTQ5JmNtZD1pdGVtZWRpdG9yaW1hZ2UmZmlsZW5hbWU9aXRlbWVkaXRvcmltYWdlXzYwZGRlNDY5MWEwNWYucG5nJnZlcnNpb249MDAwMCZzaWc9MTcyNDAwYTA3MzhkMGYxYjRjNjlhNzgwNTZiZjUwNjQ%25253D&size=1&version=1715959730&sig=3c3ce4e4512ad41e707f214b65c30d84&default=hubs%2Ftilebg-videos.jpg)
Targeted protein degradation using molecular glues or proteolysis-targeting chimeras (PROTACs) is an increasingly important therapeutic modality, especially for undruggable targets. Even with candidat
![Why so many companies are betting on PROTACs as a superior therapeutic modality](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fnanotempertech.com%2Fwp-content%2Fuploads%2F2021%2F09%2Fplanes-Featured-Image.png&size=1&version=1720526038&sig=001bf67c578ad5186d393b09a22203ec&default=hubs%2Ftilebg-blogs.jpg)
One advantage of PROTACs is their unique mode of action — the induced proximity of an E3 ligase and the protein of interest (POI) triggers the ubiquitination and then degradation of the POI by the...
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SARS-CoV-2, the causative agent of COVID-19, has an ssRNA genome of almost 30kb that encodes for a total of 26 proteins. Among the four structural viral protein, in particular the S protein stands out
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Explore the complexities and drivers of molecular interactions with Dr. Tom Laue from the University of New Hampshire. He presented as a keynote speaker in the Protein Stability & Function: Can't have
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Dr. Leah Pandiscia and Dr. Daniel Turman review how to integrate the Prometheus Panta and Monolith instruments in a characterization workflow demonstration, showing how to maximize stability and funct
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NanoTemper’s newest Monolith instrument has been awarded the globally renowned iF DESIGN AWARD 2021. User-friendly design has always been a core focus in NanoTemper’s product development....