Gene Therapy

  • Learn the pros and cons of these 3 methods to serotype your AAV gene therapy vectors

    Learn the pros and cons of these 3 methods to serotype your AAV gene therapy vectors

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  • 5 benefits of optimizing your formulation buffer to get your AAV therapeutic approved

    5 benefits of optimizing your formulation buffer to get your AAV therapeutic approved

    As a gene therapy scientist, you face an abundance of challenges when working to build an effective AAV therapeutic. Many steps of the development workflow have yet to be standardized and the...

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  • Serotyping: why, when, and how to assess your AAV therapeutic to get it approved14:07

    Serotyping: why, when, and how to assess your AAV therapeutic to get it approved

    When you develop an AAV therapeutic, you need to assess many key parameters, or Critical Quality Attributes (CQAs), in order to track progress and, ultimately, get your therapeutic approved. As part

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  • 8 Gene Therapy conferences you should attend in 2022

    8 Gene Therapy conferences you should attend in 2022

    With the first AAV-based gene therapies approved, and new gene editing strategies emerging, it’s important to stay on top of the latest topics in this therapeutic area. Here are 8 gene therapy...

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  • Ways light scattering technologies help you if you’re in gene therapy

    Ways light scattering technologies help you if you’re in gene therapy

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    Working in gene therapy?

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  • Four technologies to profile your AAVs

    Four technologies to profile your AAVs

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  • Use stability profiling to build more effective gene therapy vectors with Prometheus Panta

    Use stability profiling to build more effective gene therapy vectors with Prometheus Panta

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  • NanoTemper Technologies arms gene therapy scientists with Static Light Scattering to sharpen their tool kit for development of AAVs

    NanoTemper Technologies arms gene therapy scientists with Static Light Scattering to sharpen their tool kit for development of AAVs

    SOUTH SAN FRANCISCO, Calif Feb 16 2022 — NanoTemper Technologies today announced the addition of Static Light Scattering (SLS) to their wildly successful Prometheus Panta, turning their instrument...

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  • Trying to develop safe and effective gene therapies?

    A biophysical tool for AAV profiling will help

    Find out more
  • Overcome bottlenecks in viral vector manufacturing25:08

    Overcome bottlenecks in viral vector manufacturing

    The success of your gene therapy vectors is dependent on optimal formulation conditions. Finding a buffer that provides better long-term stability for AAVs is a crucial step in the process of developi

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  • Find out about biophysical methods to develop
    safe and effective
    gene therapies

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  • How to improve outcomes of your viral vectors for gene therapy with high-quality data from biophysical profiling methods21:48

    How to improve outcomes of your viral vectors for gene therapy with high-quality data from biophysical profiling methods

    Optimizing your vectors for gene therapy is a daunting task. When developing and optimizing AAVs, concerns such as serotype, storage stability, expression method, and genetic fill level must be addres

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  • The importance of molecular interactions and stability in Gene Therapy46:44

    The importance of molecular interactions and stability in Gene Therapy

    New advances in gene therapy have triggered a resurgence of interest in the field. Though gene therapy offers exciting potential for the treatment of both monogenic disorders as well as more genetical

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  • Solutions for gene therapy using a deeper analytical characterization of AAV vector development18:38

    Solutions for gene therapy using a deeper analytical characterization of AAV vector development

    Gene therapy—a type of DNA-based medicine that utilizes a virus to insert a healthy gene into cells to replace a mutated, disease-causing variant has emerged as one of the most promising medical treat

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  • Methods Matter: Standard production platforms for recombinant AAV produce chemically and functionally distinct vectors

    Methods Matter: Standard production platforms for recombinant AAV produce chemically and functionally distinct vectors

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  • Quantitation of trace levels of DNA released from disrupted Adeno-associated virus gene therapy vectors

    Quantitation of trace levels of DNA released from disrupted Adeno-associated virus gene therapy vectors

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  • Practical strategies for overcoming challenges in the development of AAV vectors for gene therapy38:40

    Practical strategies for overcoming challenges in the development of AAV vectors for gene therapy

    Gene therapy promises to treat and potentially cure a disease by correcting its underlying genetic cause. While gene therapies that utilize AAV vectors have shown encouraging results —including a few

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  • Francisella novicida Cas9 interrogates genomic DNA with very high specificity and can be used for mammalian genome editing

    Francisella novicida Cas9 interrogates genomic DNA with very high specificity and can be used for mammalian genome editing

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  • Antibody-targeted chromatin enables effective intracellular delivery and functionality of CRISPR/Cas9 expression plasmids

    Antibody-targeted chromatin enables effective intracellular delivery and functionality of CRISPR/Cas9 expression plasmids

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  • Intrinsic differential scanning fluorimetry for fast and easy identification of Adeno-Associated Virus serotypes

    Intrinsic differential scanning fluorimetry for fast and easy identification of Adeno-Associated Virus serotypes

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  • Trying to develop safe and effective gene therapies?

    A biophysical tool for AAV profiling will help

    Find out more
  • Humanized Selective CD19CAR-T Cells Treatment Shows Efficacy in B-ALL Patients Who Relapsed after Receiving Murine-Based CD19CAR-T Therapies

    Humanized Selective CD19CAR-T Cells Treatment Shows Efficacy in B-ALL Patients Who Relapsed after Receiving Murine-Based CD19CAR-T Therapies

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  • Find out about biophysical methods to develop
    safe and effective
    gene therapies

    Read more
  • Spatial screening of hemagglutinin on Influenza A Virus particles: Sialyl-LacNAc displays on DNA and PEG scaffolds reveal requirements

    Spatial screening of hemagglutinin on Influenza A Virus particles: Sialyl-LacNAc displays on DNA and PEG scaffolds reveal requirements

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