Neurodegenerative Diseases

  • Advance your understanding of neurodegenerative diseases

    Advance your understanding of neurodegenerative diseases

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  • Easily characterize the molecular mechanisms of neurodegenerative diseases

    Easily characterize the molecular mechanisms of neurodegenerative diseases

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  • 4 ways to help you overcome the limitations of current methods in neurodegenerative disease research

    4 ways to help you overcome the limitations of current methods in neurodegenerative disease research

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  • Characterize the molecular mechanisms of neurodegenerative diseases

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  • These 7 key proteins may hold the key to effective therapies for neurodegenerative diseases

    These 7 key proteins may hold the key to effective therapies for neurodegenerative diseases

    Despite the vast differences in symptoms experienced by patients with neurodegenerative diseases (ND), their pathology shares similar features at a molecular level. Most notably, many ND involve...

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  • Site-specific phosphorylation of tau inhibits amyloid-β toxicity in Alzheimer’s mice

    Site-specific phosphorylation of tau inhibits amyloid-β toxicity in Alzheimer’s mice

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  • 3 biggest challenges in neurodegenerative disease research and why you should focus on them

    3 biggest challenges in neurodegenerative disease research and why you should focus on them

    Neurodegenerative diseases (ND) are very complex disorders. Not only is each one different, displaying unique combinations of symptoms and progressing at varying rates, but the biochemical...

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  • Elongator mutation in mice induces neurodegeneration and ataxia-like behavior

    Elongator mutation in mice induces neurodegeneration and ataxia-like behavior

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  • 10 ways to fund your neurodegenerative disease research (that aren’t just the government)

    10 ways to fund your neurodegenerative disease research (that aren’t just the government)

    Neurodegenerative diseases (ND) are already taking a huge toll on the aging world population. Alzheimer’s disease, in particular, impacts more than 5 million Americans, and The Harvard...

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  • Zinc binding to RNA recognition motif of TDP-43 induces the formation of amyloid-like aggregates

    Zinc binding to RNA recognition motif of TDP-43 induces the formation of amyloid-like aggregates

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  • Neurodegenerative Diseases: Studying protein aggregation using NanoTemper instruments16:04

    Neurodegenerative Diseases: Studying protein aggregation using NanoTemper instruments

    Neurodegenerative diseases like Alzheimer’s or Parkinson’s Disease affect millions of people worldwide. Although current treatments may help relieve some of the physical or mental symptoms, there is s

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  • Prolyl oligopeptidase enhances alpha-syn dimerization

    Prolyl oligopeptidase enhances alpha-syn dimerization

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  • Structural basis of small molecule targetability of monomeric tau protein

    Structural basis of small molecule targetability of monomeric tau protein

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  • New peptide inhibitors modulate the self-assembly of islet amyloid polypeptide residues 11–20 in vitro

    New peptide inhibitors modulate the self-assembly of islet amyloid polypeptide residues 11–20 in vitro

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  • Rescue of cognitive deficits in APP/PS1 mice by accelerating the aggregation of ß-amyloid peptide

    Rescue of cognitive deficits in APP/PS1 mice by accelerating the aggregation of ß-amyloid peptide

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  • An engineered monomer binding-protein for alpha-syn efficiently inhibits the proliferation of amyloid fibrils

    An engineered monomer binding-protein for alpha-syn efficiently inhibits the proliferation of amyloid fibrils

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  • Quantitative thermophoretic study of disease-related protein aggregates

    Quantitative thermophoretic study of disease-related protein aggregates

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  • A small compound targeting prohibitin with potential interest for cognitive deficit rescue in aging mice and tau pathology treatment

    A small compound targeting prohibitin with potential interest for cognitive deficit rescue in aging mice and tau pathology treatment

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  • The voltage-dependent anion channel 1 mediates amyloid ß toxicity and represents a potential target for AD therapy

    The voltage-dependent anion channel 1 mediates amyloid ß toxicity and represents a potential target for AD therapy

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  • A biophysical approach to the identification of novel ApoE chemical probes

    A biophysical approach to the identification of novel ApoE chemical probes

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  • Solution-based determination of dissociation constants for the binding of Aß42 to antibodies

    Solution-based determination of dissociation constants for the binding of Aß42 to antibodies

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