Neurodegenerative Diseases

Can bioanalytical tools solve your neurodegenerative disease research challenges? 4 questions to ask yourself

Despite extensive efforts, neurodegenerative diseases (ND) continue to feel like a pharmaceutical frontier. We have yet to see any effective drugs for conditions such as Alzheimer’s, Parkinson’s,...

4 ways to help you overcome the limitations of current methods in neurodegenerative disease research

Characterize the true nature of intrinsically disordered proteins without immobilizing them

If you study neurodegenerative diseases (ND), you already know they are one of the most challenging — and fascinating — types of diseases to study. With protein aggregation being a hallmark of ND,...

These 7 key proteins may hold the key to effective therapies for neurodegenerative diseases

Despite the vast differences in symptoms experienced by patients with neurodegenerative diseases (ND), their pathology shares similar features at a molecular level. Most notably, many ND involve...

Site-specific phosphorylation of tau inhibits amyloid-β toxicity in Alzheimer’s mice

3 biggest challenges in neurodegenerative disease research and why you should focus on them

Neurodegenerative diseases (ND) are very complex disorders. Not only is each one different, displaying unique combinations of symptoms and progressing at varying rates, but the biochemical...

Elongator mutation in mice induces neurodegeneration and ataxia-like behavior

10 ways to fund your neurodegenerative disease research (that aren’t just the government)

Neurodegenerative diseases (ND) are already taking a huge toll on the aging world population. Alzheimer’s disease, in particular, impacts more than 5 million Americans, and The Harvard...

Zinc binding to RNA recognition motif of TDP-43 induces the formation of amyloid-like aggregates

Prolyl oligopeptidase enhances alpha-syn dimerization

Structural basis of small molecule targetability of monomeric tau protein

New peptide inhibitors modulate the self-assembly of islet amyloid polypeptide residues 11–20 in vitro

Rescue of cognitive deficits in APP/PS1 mice by accelerating the aggregation of ß-amyloid peptide

An engineered monomer binding-protein for alpha-syn efficiently inhibits the proliferation of amyloid fibrils

Quantitative thermophoretic study of disease-related protein aggregates

A small compound targeting prohibitin with potential interest for cognitive deficit rescue in aging mice and tau pathology treatment

The voltage-dependent anion channel 1 mediates amyloid ß toxicity and represents a potential target for AD therapy

A biophysical approach to the identification of novel ApoE chemical probes