Monolith Publications
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Potent neutralization of clinical isolates of SARS-CoV-2 D614 and G614 variants by a monomeric, sub-nanomolar affinity nanobody
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Sweet and blind spots in E3 ligase ligand space revealed by a thermophoresis-based assay
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Lipids activate SecA for high affinity binding to the SecYEG complex
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Thermophoretic analysis of ligand-specific conformational states of the inhibitory glycine receptor embedded in copolymer nanodiscs
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Detergent-free extraction of a functional low-expressing GPCR from a human cell line
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Phospholipid membrane fluidity alters ligand binding activity of a G protein-coupled receptor by shifting the conformational equilibrium
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Phosphorylation of human aquaporin 2 (AQP2) allosterically controls its interaction with the lysosomal trafficking protein LIP5
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Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditions
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Molecular basis of nitrate uptake by the plant nitrate transporter NRT1.1
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Targeting the SARS-CoV‑2 RNA genome with small molecule binders and ribonuclease targeting chimera (RIBOTAC) degraders
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Targeted degradation of a hypoxia-associated non-coding RNA enhances the selectivity of a small molecule interacting with RNA
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The peptide PROTAC modality: a novel strategy for targeted protein ubiquitination
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A cell-permeable peptide-based PROTAC against the oncoprotein CREPT proficiently inhibits pancreatic cancer
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High-resolution structure and biophysical characterization of the nucleocapsid phosphoprotein dimerization domain from Coronavirus 2
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Francisella novicida Cas9 interrogates genomic DNA with very high specificity and can be used for mammalian genome editing
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Antibody-targeted chromatin enables effective intracellular delivery and functionality of CRISPR/Cas9 expression plasmids
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Spatial screening of hemagglutinin on Influenza A Virus particles: Sialyl-LacNAc displays on DNA and PEG scaffolds reveal requirements
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Humanized Selective CD19CAR-T Cells Treatment Shows Efficacy in B-ALL Patients Who Relapsed after Receiving Murine-Based CD19CAR-T Therapies
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Flavonoids as noncompetitive inhibitors of Dengue virus NS2B-NS3 protease: inhibition kinetics and docking studies
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Isoform-Selective ATAD2 chemical probe with novel chemical structure and unusual mode of action
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