Monolith Publications

  • Targeting the SARS-CoV‑2 RNA genome with small molecule binders and ribonuclease targeting chimera (RIBOTAC) degraders

    Targeting the SARS-CoV‑2 RNA genome with small molecule binders and ribonuclease targeting chimera (RIBOTAC) degraders

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  • Targeted degradation of a hypoxia-associated non-coding RNA enhances the selectivity of a small molecule interacting with RNA

    Targeted degradation of a hypoxia-associated non-coding RNA enhances the selectivity of a small molecule interacting with RNA

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  • The peptide PROTAC modality: a novel strategy for targeted protein ubiquitination

    The peptide PROTAC modality: a novel strategy for targeted protein ubiquitination

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  • A cell-permeable peptide-based PROTAC against the oncoprotein CREPT proficiently inhibits pancreatic cancer

    A cell-permeable peptide-based PROTAC against the oncoprotein CREPT proficiently inhibits pancreatic cancer

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  • High-resolution structure and biophysical characterization of the nucleocapsid phosphoprotein dimerization domain from Coronavirus 2

    High-resolution structure and biophysical characterization of the nucleocapsid phosphoprotein dimerization domain from Coronavirus 2

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  • Francisella novicida Cas9 interrogates genomic DNA with very high specificity and can be used for mammalian genome editing

    Francisella novicida Cas9 interrogates genomic DNA with very high specificity and can be used for mammalian genome editing

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  • Antibody-targeted chromatin enables effective intracellular delivery and functionality of CRISPR/Cas9 expression plasmids

    Antibody-targeted chromatin enables effective intracellular delivery and functionality of CRISPR/Cas9 expression plasmids

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  • Spatial screening of hemagglutinin on Influenza A Virus particles: Sialyl-LacNAc displays on DNA and PEG scaffolds reveal requirements

    Spatial screening of hemagglutinin on Influenza A Virus particles: Sialyl-LacNAc displays on DNA and PEG scaffolds reveal requirements

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  • Humanized Selective CD19CAR-T Cells Treatment Shows Efficacy in B-ALL Patients Who Relapsed after Receiving Murine-Based CD19CAR-T Therapies

    Humanized Selective CD19CAR-T Cells Treatment Shows Efficacy in B-ALL Patients Who Relapsed after Receiving Murine-Based CD19CAR-T Therapies

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  • Flavonoids as noncompetitive inhibitors of Dengue virus NS2B-NS3 protease: inhibition kinetics and docking studies

    Flavonoids as noncompetitive inhibitors of Dengue virus NS2B-NS3 protease: inhibition kinetics and docking studies

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  • Isoform-Selective ATAD2 chemical probe with novel chemical structure and unusual mode of action

    Isoform-Selective ATAD2 chemical probe with novel chemical structure and unusual mode of action

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  • The amyloidogenicity of the influenza virus PB1-derived peptide sheds light on its antiviral activity

    The amyloidogenicity of the influenza virus PB1-derived peptide sheds light on its antiviral activity

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  • GS-CA compounds: first-in-class HIV-1 capsid inhibitors covering multiple grounds

    GS-CA compounds: first-in-class HIV-1 capsid inhibitors covering multiple grounds

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  • Cucumber mosaic virus coat protein: the potential target of 1, 4-pentadien-3-one derivatives

    Cucumber mosaic virus coat protein: the potential target of 1, 4-pentadien-3-one derivatives

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  • Looking for novel capsid protein multimerization inhibitors of feline immunodeficiency virus

    Looking for novel capsid protein multimerization inhibitors of feline immunodeficiency virus

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  • Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA

    Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA

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  • The three-fold axis of the HIV-1 capsid lattice is the species-specific binding interface for TRIM5α

    The three-fold axis of the HIV-1 capsid lattice is the species-specific binding interface for TRIM5α

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  • Phage capsid nanoparticles with defined ligand arrangement block influenza virus entry

    Phage capsid nanoparticles with defined ligand arrangement block influenza virus entry

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  • A glycan shield on chimpanzee CD4 protects against infection by primate lentiviruses (HIV/SIV)

    A glycan shield on chimpanzee CD4 protects against infection by primate lentiviruses (HIV/SIV)

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  • Spatial screening of hemagglutinin on Influenza A virus particles: Sialyl-LacNAc displays on DNA and PEG scaffolds reveal the requirement

    Spatial screening of hemagglutinin on Influenza A virus particles: Sialyl-LacNAc displays on DNA and PEG scaffolds reveal the requirement

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