Prometheus | Protein Stability + Aggregation + Particle Sizing
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ReadOptimization of membrane proteins for cryo-EM: Screening of copolymer nanodiscs with Prometheus Panta
Membrane proteins present challenges for structural analysis by cryo-EM; Screening of synthetic copolymers with nanoDSF and DLS on Prometheus Panta help select the best solubilization conditions.
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ReadHow Pierre Fabre enhances their antibody developability platform with Prometheus Panta
Read why scientist Dr. Elsa Wagner chose the Prometheus Panta instrument with simultaneous measurements of DLS, nanoDSF, SLS and backreflection for developability assessment of their mAbs candidates.
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4:51WatchFour integrated technologies for biologics developability assessment
The decisions you make about your biologics candidates early in the pipeline ultimately affect their success as therapeutics. Combine sizing and stability information to develop successful biologics
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Select the best biologics candidates with high-quality, multi-parameter stability characterization
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9:42WatchVirtual Prometheus Panta demo: Four integrated technologies for protein stability characterization
Your protein stability characterization projects require tools that provide high-precision, high-quality data to support your selection process. Watch this 10 min walkthrough of Prometheus Panta.
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16:24WatchDe-risk your antibody characterization workflows with high-quality, multi-parameter stability data from Prometheus Panta
Get developability profiles for monoclonal antibodies with stability data from Prometheus Panta to inform on rational design and selection of therapeutic constructs that will succeed in the clinic.
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38:20WatchConversation: How Aaron Frimel from Thermo Fisher Scientific approaches biologics formulation
Join this conversation to gain insight into how the Analytical and Formulation Sciences team at Thermo Fisher Scientific approaches stability assessment of biologic, and how the Prometheus Panta helps
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Read5 considerations for buffer optimization during biologics pre-formulation
The work of pre-formulations scientists is critical to de-risk the entire development process for biologics. Read on to learn more about what to consider about your buffer components for...
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22:59WatchBiologics Formulation: Select optimal buffer conditions with multi-parameter stability characterization from Prometheus Panta
Learn how to identify optimal buffer conditions during pre-formulation, with multi-parameter stability characterization from Prometheus Panta, a tool to collect thermal and colloidal data while saving
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Read5 types of formulation excipients and how they impact biologics stability
For pre-formulations researchers looking to find buffers that stabilize early development biologic products, buffer optimization goes beyond the pH and salt concentration of the solution....
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20:19WatchExplore Prometheus Panta – Biologics developability assessment with four integrated technologies
Developability assessment is a critical part of the evaluation and selection of candidates for further optimization and development for biologics researchers. This work entails collecting, ranking, an
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1:41WatchPrometheus Panta: The new gold standard for biologics characterization
Choosing the right stability characterization tool for your biologics research is a big commitment. You’re going to be screening and optimizing lots of candidates, and you’ll need data on thermal stab
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8:38WatchExplore Prometheus Panta – Frequently asked questions about stability profiling experiments
In this video, Nathan Wallace, Application Specialist at NanoTemper, addresses common questions about experimental design for developability profiling and the operation of Prometheus Panta.
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19:07WatchHow stability prediction experiments give you confidence in your ADCs
For antibody-drug conjugate (ADC) development, scientists rely on stability experiments using fluorescence and light scattering techniques to predict the conjugated molecule's behavior.
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ReadGet predictive insight into your ADC’s stability with these 3 experiments
Learn how it’s possible to use the Prometheus Panta to extrapolate how your low concentration sample will behave once it’s scaled up and at higher concentrations used for clinical administration.
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17:08WatchAssess the impact of bioconjugation with multi-parameter stability characterization
Characterize the developability of antibody-drug conjugates: Multi-parameter stability assessment with Prometheus Panta makes it possible to examine multiple aspects of ADC stability in parallel.
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ReadThe biologics researcher's mini-guide to screening candidates with nanoDSF
Read this nanoDSF guide to learn how nano-Differential Scanning Fluorimetry (nanoDSF) uses your protein’s intrinsic fluorescence to determine its melting temperature, Tm and onset of melting, Ton.
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38:31WatchnanoDSF for biologics: How to interpret thermal unfolding profiles for your different applications
Thermal stability screening is a common approach used to study the developability of a wide range of protein-based therapeutics. Among the different technologies available to perform thermal stability
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ReadWhy nanoDSF is the preferred method to assess the thermal stability of your therapeutic proteins
Learn about Differential Scanning Calorimetry (DSC), Circular Dichroism (CD), Extrinsic Differential Scanning Fluorimetry, and nano-Differential Scanning Fluorimetry for thermal stability of proteins
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24:28WatchThermal stability measurements for biologics developability profiling
Learn about four methods for thermal stability measurements: DSC, CD, DSF and nanoDSF. You'll review their pros and cons, what they data tell you and why it's important for biologics developability.
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