Prometheus | Protein Stability + Aggregation + Particle Sizing

  • How stability prediction experiments give you confidence in your ADCs19:07

    How stability prediction experiments give you confidence in your ADCs

    For antibody-drug conjugate (ADC) development, scientists rely on stability experiments using fluorescence and light scattering techniques to predict the conjugated molecule's behavior.

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  • Conversation:  How Aaron Frimel from Thermo Fisher Scientific approaches biologics formulation38:20

    Conversation: How Aaron Frimel from Thermo Fisher Scientific approaches biologics formulation

    Join this conversation to gain insight into how the Analytical and Formulation Sciences team at Thermo Fisher Scientific approaches stability assessment of biologic, and how the Prometheus Panta helps

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  • 5 biologics conferences you won’t want to miss in 2024

    5 biologics conferences you won’t want to miss in 2024

    Use this list of crowd-sourced favorites to kick-start your 2024 biologics conference plans. Find out when and where each conference takes place, who will be there, which topics are covered, and...

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  • De-risk your ADC development process with these stability considerations

    De-risk your ADC development process with these stability considerations

    Antibody-drug conjugates, or ADCs, are revolutionary therapeutics that represent a growing proportion of the biologics market. They combine the targeting power of a monoclonal antibody, which is...

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  • How to mitigate risk during ADC development with multi-parameter stability characterization19:16

    How to mitigate risk during ADC development with multi-parameter stability characterization

    To assess the developability properties of antibody-drug conjugates (ADCs) learn about multi-parameter characterization of thermal and colloidal stability with Prometheus Panta using nanoDSF and DLS

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  • Ready to tackle your challenging stability characterizations?

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  • Explore Prometheus Panta – Biologics developability assessment with four integrated technologies20:19

    Explore Prometheus Panta – Biologics developability assessment with four integrated technologies

    Developability assessment is a critical part of the evaluation and selection of candidates for further optimization and development for biologics researchers. This work entails collecting, ranking, an

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  • Select the best biologics candidates with high-quality, multi-parameter stability characterization

    Select the best biologics candidates with high-quality, multi-parameter stability characterization

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  • Four integrated technologies for Biologics developability assessment4:51

    Four integrated technologies for Biologics developability assessment

    The decisions you make about your biologics candidates early in the pipeline ultimately affect their success as therapeutics. Combine sizing and stability information to develop successful biologics

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  • Explore Prometheus Panta – Frequently asked questions about stability profiling experiments8:38

    Explore Prometheus Panta – Frequently asked questions about stability profiling experiments

    In this video, Nathan Wallace, Application Specialist at NanoTemper, addresses common questions about experimental design for developability profiling and the operation of Prometheus Panta.

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  • nanoDSF for biologics: How to interpret thermal unfolding profiles for your different applications38:31

    nanoDSF for biologics: How to interpret thermal unfolding profiles for your different applications

    Thermal stability screening is a common approach used to study the developability of a wide range of protein-based therapeutics. Among the different technologies available to perform thermal stability

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  • Thermal stability measurements for biologics developability profiling24:28

    Thermal stability measurements for biologics developability profiling

    Learn about four methods for thermal stability measurements: DSC, CD, DSF and nanoDSF. You'll review their pros and cons, what they data tell you and why it's important for biologics developability.

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  • The biologics researcher's mini-guide to screening candidates with nanoDSF

    The biologics researcher's mini-guide to screening candidates with nanoDSF

    Read this nanoDSF guide to learn how nano-Differential Scanning Fluorimetry (nanoDSF) uses your protein’s intrinsic fluorescence to determine its melting temperature, Tm and onset of melting, Ton.

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  • Why nanoDSF is the preferred method to assess the thermal stability of your therapeutic proteins

    Why nanoDSF is the preferred method to assess the thermal stability of your therapeutic proteins

    Learn about Differential Scanning Calorimetry (DSC), Circular Dichroism (CD), Extrinsic Differential Scanning Fluorimetry, and nano-Differential Scanning Fluorimetry for thermal stability of proteins

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  • How four stability assessment technologies support biologics early development

    How four stability assessment technologies support biologics early development

    During early development of biologics, there are many attributes scientists evaluate for developability. Measure them with biophysical characterization using nanoDSF, DLS, backreflection, and SLS.

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  • How stability characterization parameters help you create biologics developability profiles

    How stability characterization parameters help you create biologics developability profiles

    Developability profiles help you avoid risk by collecting many quality attributes associated with each candidate, enabling you to rank each candidate by the most optimal attributes and make a...

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  • How biologics teams approach developability screening of their candidates with combinatorial stability characterization21:31

    How biologics teams approach developability screening of their candidates with combinatorial stability characterization

    Full developability profiles de-risk the selection process for biologics candidates during early development workflows. There are many critical quality attributes to evaluate when it comes to developa

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  • How to use light scattering techniques to predict your biologic’s self-association behavior at high concentrations17:33

    How to use light scattering techniques to predict your biologic’s self-association behavior at high concentrations

    Developability work requires the assessment of multiple critical quality attributes (CQAs) of your biologics. Many of these CQAs are measured or monitored using low-volume, low-concentration samples.

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  • Use light-scattering techniques to predict how your early development candidates will behave at high concentrations for the clinic

    Use light-scattering techniques to predict how your early development candidates will behave at high concentrations for the clinic

    Light scattering techniques are used to predict high-concentration behavior of candidates early in the development process. Let's take a look at what they tell you, how to set them up, and how...

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  • What to consider when adding DLS to your early biologics development workflow (FAQs and practical tips)

    What to consider when adding DLS to your early biologics development workflow (FAQs and practical tips)

    Read on to find the answers to questions your early development scientist peers have asked about how to use DLS to design, select, and advance the most stable biologics candidates.

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  • Prometheus Panta: The new gold standard for biologics characterization1:41

    Prometheus Panta: The new gold standard for biologics characterization

    Choosing the right stability characterization tool for your biologics research is a big commitment. You’re going to be screening and optimizing lots of candidates, and you’ll need data on thermal stab

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