Prometheus | Protein Stability + Aggregation + Particle Sizing

  • De-risk your antibody characterization workflows with high-quality, multi-parameter stability data from Prometheus Panta16:24

    De-risk your antibody characterization workflows with high-quality, multi-parameter stability data from Prometheus Panta

    Get developability profiles for monoclonal antibodies with stability data from Prometheus Panta to inform on rational design and selection of therapeutic constructs that will succeed in the clinic.

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  • Biologics Formulation: Select optimal buffer conditions with multi-parameter stability characterization from Prometheus Panta22:59

    Biologics Formulation: Select optimal buffer conditions with multi-parameter stability characterization from Prometheus Panta

    Learn how to identify optimal buffer conditions during pre-formulation, with multi-parameter stability characterization from Prometheus Panta, a tool to collect thermal and colloidal data while saving

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  • 5 considerations for buffer optimization during biologics pre-formulation

    5 considerations for buffer optimization during biologics pre-formulation

    Formulation development is a long, ongoing process during a candidate’s lifecycle. Broadly, it’s segmented into three categories: pre-formulation, formulation, and process development. The work of...

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  • 5 types of formulation excipients and how they impact biologics stability

    5 types of formulation excipients and how they impact biologics stability

    For pre-formulations researchers looking to find buffers that stabilize early development biologic products, buffer optimization goes beyond the pH and salt concentration of the solution....

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  • Four integrated technologies for biologics developability assessment4:51

    Four integrated technologies for biologics developability assessment

    The decisions you make about your biologics candidates early in the pipeline ultimately affect their success as therapeutics. Combine sizing and stability information to develop successful biologics

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  • Select the best biologics candidates with high-quality, multi-parameter stability characterization

    Select the best biologics candidates with high-quality, multi-parameter stability characterization

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  • Virtual Prometheus Panta demo: Four integrated technologies for protein stability characterization9:42

    Virtual Prometheus Panta demo: Four integrated technologies for protein stability characterization

    Your protein stability characterization projects require tools that provide high-precision, high-quality data to support your selection process. Watch this 10 min walkthrough of Prometheus Panta.

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  • Conversation:  How Aaron Frimel from Thermo Fisher Scientific approaches biologics formulation38:20

    Conversation: How Aaron Frimel from Thermo Fisher Scientific approaches biologics formulation

    Join this conversation to gain insight into how the Analytical and Formulation Sciences team at Thermo Fisher Scientific approaches stability assessment of biologic, and how the Prometheus Panta helps

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  • Explore Prometheus Panta – Biologics developability assessment with four integrated technologies20:19

    Explore Prometheus Panta – Biologics developability assessment with four integrated technologies

    Developability assessment is a critical part of the evaluation and selection of candidates for further optimization and development for biologics researchers. This work entails collecting, ranking, an

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  • Explore Prometheus Panta – Frequently asked questions about stability profiling experiments8:38

    Explore Prometheus Panta – Frequently asked questions about stability profiling experiments

    In this video, Nathan Wallace, Application Specialist at NanoTemper, addresses common questions about experimental design for developability profiling and the operation of Prometheus Panta.

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  • Prometheus Panta: The new gold standard for biologics characterization1:41

    Prometheus Panta: The new gold standard for biologics characterization

    Choosing the right stability characterization tool for your biologics research is a big commitment. You’re going to be screening and optimizing lots of candidates, and you’ll need data on thermal stab

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  • Assess the impact of bioconjugation with multi-parameter stability characterization17:08

    Assess the impact of bioconjugation with multi-parameter stability characterization

    Characterize the developability of antibody-drug conjugates: Multi-parameter stability assessment with Prometheus Panta makes it possible to examine multiple aspects of ADC stability in parallel.

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  • nanoDSF for biologics: How to interpret thermal unfolding profiles for your different applications38:31

    nanoDSF for biologics: How to interpret thermal unfolding profiles for your different applications

    Thermal stability screening is a common approach used to study the developability of a wide range of protein-based therapeutics. Among the different technologies available to perform thermal stability

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  • Why nanoDSF is the preferred method to assess the thermal stability of your therapeutic proteins

    Why nanoDSF is the preferred method to assess the thermal stability of your therapeutic proteins

    Learn about Differential Scanning Calorimetry (DSC), Circular Dichroism (CD), Extrinsic Differential Scanning Fluorimetry, and nano-Differential Scanning Fluorimetry for thermal stability of proteins

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  • Thermal stability measurements for biologics developability profiling24:28

    Thermal stability measurements for biologics developability profiling

    Learn about four methods for thermal stability measurements: DSC, CD, DSF and nanoDSF. You'll review their pros and cons, what they data tell you and why it's important for biologics developability.

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  • The biologics researcher's mini-guide to screening candidates with nanoDSF

    The biologics researcher's mini-guide to screening candidates with nanoDSF

    Read this nanoDSF guide to learn how nano-Differential Scanning Fluorimetry (nanoDSF) uses your protein’s intrinsic fluorescence to determine its melting temperature, Tm and onset of melting, Ton.

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  • How stability prediction experiments give you confidence in your ADCs19:07

    How stability prediction experiments give you confidence in your ADCs

    For antibody-drug conjugate (ADC) development, scientists rely on stability experiments using fluorescence and light scattering techniques to predict the conjugated molecule's behavior.

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  • Get predictive insight into your ADC’s stability with these 3 experiments

    Get predictive insight into your ADC’s stability with these 3 experiments

    When developing ADCs, there are some strategies for protein assessment that will help mitigate the risk of destabilizing the final product during early development, particularly when optimizing...

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  • How to mitigate risk during ADC development with multi-parameter stability characterization19:16

    How to mitigate risk during ADC development with multi-parameter stability characterization

    To assess the developability properties of antibody-drug conjugates (ADCs) learn about multi-parameter characterization of thermal and colloidal stability with Prometheus Panta using nanoDSF and DLS

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  • De-risk your ADC development process with these stability considerations

    De-risk your ADC development process with these stability considerations

    Antibody-drug conjugates, or ADCs, are revolutionary therapeutics that represent a growing proportion of the biologics market. They combine the targeting power of a monoclonal antibody, which is...

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