Virology
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13:27WatchMolecular tools to study viral infectious diseases
Pandemics have affected human society throughout history, but with the current pandemic happening today, realization is quickly setting in just how much viral infectious diseases impact everyday life.
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ReadStepwise conformational stabilization of a HIV-1 clade C consensus envelope trimer immunogen impacts vaccine-induced antibody responses
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ReadRapid development of SARS-CoV-2 spike protein receptor-binding domain self-assembled nanoparticle vaccine candidates
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Challenged by the complexity of
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ReadCapsid lattice destabilization leads to premature loss of the viral genome and integrase enzyme during HIV-1 infection
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35:24WatchEffect of different SARS-CoV-2 variants on COVID 19 assays and vaccines
SARS-CoV-2, the causative agent of COVID-19, has an ssRNA genome of almost 30kb that encodes for a total of 26 proteins. Among the four structural viral protein, in particular the S protein stands out
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44:38WatchMeasuring multivalent interactions: uncovering the secrets of virus binding strategies
Influenza A virus (IAV) utilizes a multivalent binding strategy to the host cell, binding its trimeric spike protein hemagglutinin (HA) to sialic acid present on the cellular membrane. For this reason
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ReadPotent neutralization of clinical isolates of SARS-CoV-2 D614 and G614 variants by a monomeric, sub-nanomolar affinity nanobody
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ReadSelection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2
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ReadWhat these 3 publications uncovered about coronavirus protein structures using MST
Coronaviruses (CoV) have been responsible for multiple outbreaks this century. The COVID-19 pandemic — caused by the novel SARS-CoV-2 coronavirus — has led to a global health, social, and economic...
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ReadHigh-resolution structure and biophysical characterization of the nucleocapsid phosphoprotein dimerization domain from Coronavirus 2
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ReadnanoDSF: In vitro label-free method to monitor Picornavirus uncoating and test compounds affecting particle stability
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ReadCryo-electron microscopy structure of a coronavirus spike glycoprotein trimer
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ReadStructural and biochemical characterization of endoribonuclease nsp15 encoded by Middle East respiratory syndrome Coronavirus
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Challenged by the complexity of
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virus biology?
Biophysical methods can help. -
ReadDimerization of Coronavirus nsp9 with diverse modes enhances its nucleic acid binding affinity
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ReadThermodynamic origins of protein folding, allostery, and capsid formation in the human hepatitis B virus core protein
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ReadMetal chelators for the inhibition of the lymphocytic choriomeningitis virus endonuclease domain.
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ReadCharacterization and structure of the vaccinia virus NF-κB antagonist A46
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ReadCoagulation factor VIIa binds to herpes simplex virus 1‐encoded glycoprotein C forming a factor X‐enhanced tenase complex oriented on mem
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ReadPhage capsid nanoparticles with defined ligand arrangement block influenza virus entry
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ReadThe three-fold axis of the HIV-1 capsid lattice is the species-specific binding interface for TRIM5α
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