Virology

  • nanoDSF: In vitro label-free method to monitor Picornavirus uncoating and test compounds affecting particle stability

    nanoDSF: In vitro label-free method to monitor Picornavirus uncoating and test compounds affecting particle stability

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  • What these 3 publications uncovered about coronavirus protein structures using MST

    What these 3 publications uncovered about coronavirus protein structures using MST

    Coronaviruses (CoV) have been responsible for multiple outbreaks this century. The COVID-19 pandemic — caused by the novel SARS-CoV-2 coronavirus — has led to a global health, social, and economic...

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  • Measuring multivalent interactions: uncovering the secrets of virus binding strategies44:38

    Measuring multivalent interactions: uncovering the secrets of virus binding strategies

    Influenza A virus (IAV) utilizes a multivalent binding strategy to the host cell, binding its trimeric spike protein hemagglutinin (HA) to sialic acid present on the cellular membrane. For this reason

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  • Challenged by the complexity of
    virus biology?

    Biophysical methods can help.

    Find out how
  • Molecular tools to study viral infectious diseases13:27

    Molecular tools to study viral infectious diseases

    Pandemics have affected human society throughout history, but with the current pandemic happening today, realization is quickly setting in just how much viral infectious diseases impact everyday life.

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  • Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer

    Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer

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  • Structural and biochemical characterization of endoribonuclease nsp15 encoded by Middle East respiratory syndrome Coronavirus

    Structural and biochemical characterization of endoribonuclease nsp15 encoded by Middle East respiratory syndrome Coronavirus

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  • Dimerization of Coronavirus nsp9 with diverse modes enhances its nucleic acid binding affinity

    Dimerization of Coronavirus nsp9 with diverse modes enhances its nucleic acid binding affinity

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  • Thermodynamic origins of protein folding, allostery, and capsid formation in the human hepatitis B virus core protein

    Thermodynamic origins of protein folding, allostery, and capsid formation in the human hepatitis B virus core protein

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  • Metal chelators for the inhibition of the lymphocytic choriomeningitis virus endonuclease domain.

    Metal chelators for the inhibition of the lymphocytic choriomeningitis virus endonuclease domain.

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  • Characterization and structure of the vaccinia virus NF-κB antagonist A46

    Characterization and structure of the vaccinia virus NF-κB antagonist A46

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  • Coagulation factor VIIa binds to herpes simplex virus 1‐encoded glycoprotein C forming a factor X‐enhanced tenase complex oriented on mem

    Coagulation factor VIIa binds to herpes simplex virus 1‐encoded glycoprotein C forming a factor X‐enhanced tenase complex oriented on mem

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  • Phage capsid nanoparticles with defined ligand arrangement block influenza virus entry

    Phage capsid nanoparticles with defined ligand arrangement block influenza virus entry

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  • The three-fold axis of the HIV-1 capsid lattice is the species-specific binding interface for TRIM5α

    The three-fold axis of the HIV-1 capsid lattice is the species-specific binding interface for TRIM5α

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  • Challenged by the complexity of
    virus biology?

    Biophysical methods can help.

    Find out how
  • The rotavirus nonstructural protein NSP5 coordinates a [2Fe-2S] iron-sulfur cluster that modulates interaction to RNA

    The rotavirus nonstructural protein NSP5 coordinates a [2Fe-2S] iron-sulfur cluster that modulates interaction to RNA

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  • A glycan shield on chimpanzee CD4 protects against infection by primate lentiviruses (HIV/SIV)

    A glycan shield on chimpanzee CD4 protects against infection by primate lentiviruses (HIV/SIV)

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  • Spatial screening of hemagglutinin on Influenza A virus particles: Sialyl-LacNAc displays on DNA and PEG scaffolds reveal the requirement

    Spatial screening of hemagglutinin on Influenza A virus particles: Sialyl-LacNAc displays on DNA and PEG scaffolds reveal the requirement

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  • Looking for novel capsid protein multimerization inhibitors of feline immunodeficiency virus

    Looking for novel capsid protein multimerization inhibitors of feline immunodeficiency virus

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  • Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA

    Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA

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  • Flavonoids as noncompetitive inhibitors of Dengue virus NS2B-NS3 protease: inhibition kinetics and docking studies

    Flavonoids as noncompetitive inhibitors of Dengue virus NS2B-NS3 protease: inhibition kinetics and docking studies

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  • GS-CA compounds: first-in-class HIV-1 capsid inhibitors covering multiple grounds

    GS-CA compounds: first-in-class HIV-1 capsid inhibitors covering multiple grounds

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