Virology

  • Molecular tools to study viral infectious diseases13:27

    Molecular tools to study viral infectious diseases

    Pandemics have affected human society throughout history, but with the current pandemic happening today, realization is quickly setting in just how much viral infectious diseases impact everyday life.

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  • Stepwise conformational stabilization of a HIV-1 clade C consensus envelope trimer immunogen impacts vaccine-induced antibody responses

    Stepwise conformational stabilization of a HIV-1 clade C consensus envelope trimer immunogen impacts vaccine-induced antibody responses

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  • Rapid development of SARS-CoV-2 spike protein receptor-binding domain self-assembled nanoparticle vaccine candidates

    Rapid development of SARS-CoV-2 spike protein receptor-binding domain self-assembled nanoparticle vaccine candidates

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  • Challenged by the complexity of
    virus biology?

    Biophysical methods can help.

    Find out how
  • Capsid lattice destabilization leads to premature loss of the viral genome and integrase enzyme during HIV-1 infection

    Capsid lattice destabilization leads to premature loss of the viral genome and integrase enzyme during HIV-1 infection

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  • Effect of different SARS-CoV-2 variants on COVID 19 assays and vaccines35:24

    Effect of different SARS-CoV-2 variants on COVID 19 assays and vaccines

    SARS-CoV-2, the causative agent of COVID-19, has an ssRNA genome of almost 30kb that encodes for a total of 26 proteins. Among the four structural viral protein, in particular the S protein stands out

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  • Measuring multivalent interactions: uncovering the secrets of virus binding strategies44:38

    Measuring multivalent interactions: uncovering the secrets of virus binding strategies

    Influenza A virus (IAV) utilizes a multivalent binding strategy to the host cell, binding its trimeric spike protein hemagglutinin (HA) to sialic acid present on the cellular membrane. For this reason

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  • Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2

    Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2

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  • What these 3 publications uncovered about coronavirus protein structures using MST

    What these 3 publications uncovered about coronavirus protein structures using MST

    The absence of a vaccine and antiviral drugs is partly due to a poor understanding of the structural characteristics of the viral proteins that are responsible for viral infection and replication....

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  • High-resolution structure and biophysical characterization of the nucleocapsid phosphoprotein dimerization domain from Coronavirus 2

    High-resolution structure and biophysical characterization of the nucleocapsid phosphoprotein dimerization domain from Coronavirus 2

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  • nanoDSF: In vitro label-free method to monitor Picornavirus uncoating and test compounds affecting particle stability

    nanoDSF: In vitro label-free method to monitor Picornavirus uncoating and test compounds affecting particle stability

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  • Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer

    Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer

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  • Structural and biochemical characterization of endoribonuclease nsp15 encoded by Middle East respiratory syndrome Coronavirus

    Structural and biochemical characterization of endoribonuclease nsp15 encoded by Middle East respiratory syndrome Coronavirus

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  • Dimerization of Coronavirus nsp9 with diverse modes enhances its nucleic acid binding affinity

    Dimerization of Coronavirus nsp9 with diverse modes enhances its nucleic acid binding affinity

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  • Challenged by the complexity of
    virus biology?

    Biophysical methods can help.

    Find out how
  • Thermodynamic origins of protein folding, allostery, and capsid formation in the human hepatitis B virus core protein

    Thermodynamic origins of protein folding, allostery, and capsid formation in the human hepatitis B virus core protein

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  • Metal chelators for the inhibition of the lymphocytic choriomeningitis virus endonuclease domain.

    Metal chelators for the inhibition of the lymphocytic choriomeningitis virus endonuclease domain.

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  • Characterization and structure of the vaccinia virus NF-κB antagonist A46

    Characterization and structure of the vaccinia virus NF-κB antagonist A46

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  • Coagulation factor VIIa binds to herpes simplex virus 1‐encoded glycoprotein C forming a factor X‐enhanced tenase complex oriented on mem

    Coagulation factor VIIa binds to herpes simplex virus 1‐encoded glycoprotein C forming a factor X‐enhanced tenase complex oriented on mem

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  • Phage capsid nanoparticles with defined ligand arrangement block influenza virus entry

    Phage capsid nanoparticles with defined ligand arrangement block influenza virus entry

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  • The three-fold axis of the HIV-1 capsid lattice is the species-specific binding interface for TRIM5α

    The three-fold axis of the HIV-1 capsid lattice is the species-specific binding interface for TRIM5α

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  • The rotavirus nonstructural protein NSP5 coordinates a [2Fe-2S] iron-sulfur cluster that modulates interaction to RNA

    The rotavirus nonstructural protein NSP5 coordinates a [2Fe-2S] iron-sulfur cluster that modulates interaction to RNA

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