Webinars

  • The use of Spectral Shift in identifying Microcycle® hits for challenging therapeutic targets14:18

    The use of Spectral Shift in identifying Microcycle® hits for challenging therapeutic targets

    Transcription factors have traditionally been considered challenging therapeutic targets. Their intrinsic disorder and lack of small molecule binding pockets make them intractable to small molecule ap

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  • Applying Spectral Shift technology to study IDPs: Direct binding and displacement assays of MYC:MAX inhibitors11:48

    Applying Spectral Shift technology to study IDPs: Direct binding and displacement assays of MYC:MAX inhibitors

    MYC is an important therapeutic target that associates with MAX to regulate gene transcription. Its lack of binding pockets and the presence of disordered regions make it a difficult protein to study

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  • Conversation:  How Aaron Frimel from Thermo Fisher Scientific approaches biologics formulation38:20

    Conversation: How Aaron Frimel from Thermo Fisher Scientific approaches biologics formulation

    Join this conversation to gain insight into how the Analytical and Formulation Sciences team at Thermo Fisher Scientific approaches stability assessment of biologic, and how the Prometheus Panta helps

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  • How to mitigate risk during ADC development with multi-parameter stability characterization19:16

    How to mitigate risk during ADC development with multi-parameter stability characterization

    To assess the developability properties of antibody-drug conjugates (ADCs) learn about multi-parameter characterization of thermal and colloidal stability with Prometheus Panta using nanoDSF and DLS

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  • nanoDSF for biologics: How to interpret thermal unfolding profiles for your different applications38:31

    nanoDSF for biologics: How to interpret thermal unfolding profiles for your different applications

    Thermal stability screening is a common approach used to study the developability of a wide range of protein-based therapeutics. Among the different technologies available to perform thermal stability

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  • Thermal stability measurements for biologics developability profiling24:28

    Thermal stability measurements for biologics developability profiling

    Learn about four methods for thermal stability measurements: DSC, CD, DSF and nanoDSF. You'll review their pros and cons, what they data tell you and why it's important for biologics developability.

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  • Selective degradation of cancer target WDR5 — Evaluation of PROTACs binary and ternary affinities with Spectral Shift22:23

    Selective degradation of cancer target WDR5 — Evaluation of PROTACs binary and ternary affinities with Spectral Shift

    Chances are your company’s research and development pipeline includes several PROTAC candidates — placing you with many others in the race to bring successful and efficient protein degraders to the cl

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  • Explore Prometheus Panta – Frequently asked questions about stability profiling experiments8:38

    Explore Prometheus Panta – Frequently asked questions about stability profiling experiments

    In this video, Nathan Wallace, Application Specialist at NanoTemper, addresses common questions about experimental design for developability profiling and the operation of Prometheus Panta.

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  • Explore Prometheus Panta – Biologics developability assessment with four integrated technologies20:19

    Explore Prometheus Panta – Biologics developability assessment with four integrated technologies

    Developability assessment is a critical part of the evaluation and selection of candidates for further optimization and development for biologics researchers. This work entails collecting, ranking, an

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  • How to keep your degrader pipeline moving forward with Dianthus16:42

    How to keep your degrader pipeline moving forward with Dianthus

    The development of your protein degrader is a multi-step and complex process usually packed with challenges that if left unsolved will delay the progress of your project. What if you could overcome co

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  • How biologics teams approach developability screening of their candidates with combinatorial stability characterization21:31

    How biologics teams approach developability screening of their candidates with combinatorial stability characterization

    Full developability profiles de-risk the selection process for biologics candidates during early development workflows. There are many critical quality attributes to evaluate when it comes to developa

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  • How to use light scattering techniques to predict your biologic’s self-association behavior at high concentrations17:33

    How to use light scattering techniques to predict your biologic’s self-association behavior at high concentrations

    Developability work requires the assessment of multiple critical quality attributes (CQAs) of your biologics. Many of these CQAs are measured or monitored using low-volume, low-concentration samples.

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  • How biologics teams use Dynamic Light Scattering to identify leading candidates13:12

    How biologics teams use Dynamic Light Scattering to identify leading candidates

    Watch this 15 min video to learn how groups in early biologics development and formulation use Dynamic Light Scattering (DLS) to make informed decisions that de-risk downstream biologics development.

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  • Overcome bottlenecks in viral vector manufacturing25:08

    Overcome bottlenecks in viral vector manufacturing

    The success of your gene therapy vectors is dependent on optimal formulation conditions. Finding a buffer that provides better long-term stability for AAVs is a crucial step in the process of developi

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  • Put your challenging affinity screening campaigns back on track — after you’ve tried everything else37:25

    Put your challenging affinity screening campaigns back on track — after you’ve tried everything else

    When you’re entrusted with developing therapeutics for challenging or undruggable targets, it’s a struggle to characterize molecular interactions. And it’s not for lack of effort or expertise — SPR an

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  • How to improve outcomes of your viral vectors for gene therapy with high-quality data from biophysical profiling methods21:48

    How to improve outcomes of your viral vectors for gene therapy with high-quality data from biophysical profiling methods

    Optimizing your vectors for gene therapy is a daunting task. When developing and optimizing AAVs, concerns such as serotype, storage stability, expression method, and genetic fill level must be addres

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  • The autocorrelation function: the key to understanding your biological molecules25:16

    The autocorrelation function: the key to understanding your biological molecules

    Dynamic Light Scattering (DLS) is a technique that allows researchers to accurately size their biologic molecules and determine the distribution of particle sizes in a solution. In order to turn scatt

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  • How Abbvie's preformulation department assesses Drug-Like Properties of their antibody candidates28:21

    How Abbvie's preformulation department assesses Drug-Like Properties of their antibody candidates

    Join Dr. Brittney Mills as she explains what criteria AbbVie’s preformulation department screens for in their antibody candidates.

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  • How to study molecular interactions of membrane proteins without compromising their native structure14:01

    How to study molecular interactions of membrane proteins without compromising their native structure

    The desire to use technology that allows you to study membrane proteins in close-to-native conditions is specifically important when it comes to interaction measurements. It’s always a question how mu

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  • How to find expression and purification conditions that result in high levels of thermally stable membrane proteins12:06

    How to find expression and purification conditions that result in high levels of thermally stable membrane proteins

    What you’ll learn It’s very common to experience low expression levels when producing membrane proteins — plus they’re finicky and unstable when they're outside of their native environment. Just know

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