Thermal stability measurements for biologics developability profiling

September 12, 2023

Biophysical stability properties are among some of the most common quality attributes profiled in early development when evaluating protein-based therapeutics like biologics. Of all stability properties, thermal stability screening is among the most common methodologies for rapidly and reliably assessing the stability of biologics candidates.

Watch this video to learn:

  • Why thermal stability is used for biologics selection screening
  • Which methods exist for assessing thermal stability, and their pros and cons
  • How intrinsic thermal stability measurements give high resolution data that reveals critical attributes of your candidates

For an overview of the different techniques for stability measurements mentioned in this video, their pros and cons, and what the data tells you, read this infographic.

To learn more about tools for thermal stability assessment of biologics, check out Prometheus Panta.

Previous Video
nanoDSF for biologics: How to interpret thermal unfolding profiles for your different applications
nanoDSF for biologics: How to interpret thermal unfolding profiles for your different applications

Thermal stability screening is a common approach used to study the developability of a wide range of protei...

Up next
Selective degradation of cancer target WDR5 — Evaluation of PROTACs binary and ternary affinities with Spectral Shift
Selective degradation of cancer target WDR5 — Evaluation of PROTACs binary and ternary affinities with Spectral Shift

Chances are your company’s research and development pipeline includes several PROTAC candidates — placing y...