PROTACs

  • Attend these targeted protein degradation conferences in 2024 to stay in the know

    Attend these targeted protein degradation conferences in 2024 to stay in the know

    Attending dedicated targeted protein degradation conferences and tracks is a great way to keep up with this rapidly evolving field. Here are 8 conferences you’ll want to attend in 2024.

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  • Selective degradation of cancer target WDR5 — Evaluation of PROTACs binary and ternary affinities with Spectral Shift22:23

    Selective degradation of cancer target WDR5 — Evaluation of PROTACs binary and ternary affinities with Spectral Shift

    Chances are your company’s research and development pipeline includes several PROTAC candidates — placing you with many others in the race to bring successful and efficient protein degraders to the cl

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  • How to keep your degrader pipeline moving forward with Dianthus16:42

    How to keep your degrader pipeline moving forward with Dianthus

    The development of your protein degrader is a multi-step and complex process usually packed with challenges that if left unsolved will delay the progress of your project. What if you could overcome co

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  • Top 8 targeted protein degradation conferences of 2023 at a glance

    Top 8 targeted protein degradation conferences of 2023 at a glance

    Use this downloadable list of 2023 Targeted Protein Degradation conferences to choose which one(s) to attend. Learn when and where they’ll happen, who’ll be there, and the main focus.

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  • 8 Targeted Protein Degradation conferences in 2023 you won’t want to miss

    8 Targeted Protein Degradation conferences in 2023 you won’t want to miss

    2023 is expected to be a year of big announcements in the targeted protein degradation (TPD) therapeutics space. With more than 20 degraders in clinical trials, many decisions are coming. The race...

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    Working with PROTACs?

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  • How to build an effective protein degrader

    How to build an effective protein degrader

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  • Put your challenging affinity screening campaigns back on track — after you’ve tried everything else37:25

    Put your challenging affinity screening campaigns back on track — after you’ve tried everything else

    When you’re entrusted with developing therapeutics for challenging or undruggable targets, it’s a struggle to characterize molecular interactions. And it’s not for lack of effort or expertise — SPR an

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  • How to improve the function of your PROTAC degrader by understanding ternary complex formation59:35

    How to improve the function of your PROTAC degrader by understanding ternary complex formation

    Bifunctional degrader molecules (aka PROTACs) and molecular glues recruit proteins to E3 ubiquitin ligases, forming a ternary complex that enables ubiquitination and degradation of the target

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  • Trying to characterize ternary complex formation and cooperativity?

    In-solution measurements will help

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  • Why so many companies are betting on PROTACs as a superior therapeutic modality

    Why so many companies are betting on PROTACs as a superior therapeutic modality

    One advantage of PROTACs is their unique mode of action — the induced proximity of an E3 ligase and the protein of interest (POI) triggers the ubiquitination and then degradation of the POI by the...

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  • Discover tools to successfully characterize PROTAC binary and ternary complexes

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  • Rely on Dianthus to overcome roadblocks in your PROTAC characterizations

    Rely on Dianthus to overcome roadblocks in your PROTAC characterizations

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  • Characterize your PROTAC hook effect with flexible and in-solution affinity measurements for results you can trust

    Characterize your PROTAC hook effect with flexible and in-solution affinity measurements for results you can trust

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  • Improve your protein degrader design with new ways to discover E3 ligase ligands35:47

    Improve your protein degrader design with new ways to discover E3 ligase ligands

    Targeted protein degradation using molecular glues or proteolysis-targeting chimeras (PROTACs) is an increasingly important therapeutic modality, especially for undruggable targets. Even with candidat

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  • 10 terms to help you more easily understand targeted protein degradation

    10 terms to help you more easily understand targeted protein degradation

    If you’re new to the world of TPD or you’re trying to keep up with all developments in this fast-moving field, here are some terms and definitions that will help you.

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  • Protein degraders show promising results in drug development pipelines. See progress candidates have made.

    Protein degraders show promising results in drug development pipelines. See progress candidates have made.

    There has been considerable and promising development in the field of targeted protein degradation (TPD) since the seminal discovery of PROTACs in 2001.1 The appeal of degraders like PROTACs lies...

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  • 9 Targeted Protein Degradation conferences you don’t want to miss in 2022

    9 Targeted Protein Degradation conferences you don’t want to miss in 2022

    With so much interest and investment in target protein degradation, a lot can happen in a year. Here are 9 conferences to get up-to-date on recent progress and the latest approaches. You’ll not...

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  • For protein degraders to tackle neurodegenerative diseases, these are the barriers they need to overcome

    For protein degraders to tackle neurodegenerative diseases, these are the barriers they need to overcome

    The total protein degradation modality — locally and specifically targeting the disease-causing proteins and degrading their toxic aggregates — promises to be revolutionary. But the development of...

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  • Targeted protein degradation promises to lead the way to effective drugs for challenging targets

    Targeted protein degradation promises to lead the way to effective drugs for challenging targets

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  • MST and TRIC technology to reliably study PROTAC binary and ternary binding in drug development

    MST and TRIC technology to reliably study PROTAC binary and ternary binding in drug development

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  • Trying to characterize ternary complex formation and cooperativity?

    In-solution measurements will help

    Find out more
  • Ddi1 is a ubiquitin-dependent protease

    Ddi1 is a ubiquitin-dependent protease

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  • Discover tools to successfully characterize PROTAC binary and ternary complexes

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  • Are you building an effective protein degrader? 4 questions to ask yourself to find out

    Are you building an effective protein degrader? 4 questions to ask yourself to find out

    Protein degraders are getting a lot of attention for being a new and promising modality to treat diseases such as cancer or Alzheimer’s disease. Rather than inhibiting the function of a protein,...

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