PROTACs
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Are you building an effective protein degrader?
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Optimize the structure of your next round of PROTAC compounds by analyzing ternary binding affinities using Monolith
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Characterizing interactions involving PROTACs or other TACs?
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NanoTemper tools can help -
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Understanding the nuances of targeted protein degradation
Bifunctional degrader molecules (also known as PROTACs) and molecular glues recruit proteins to E3 ubiquitin ligases. The formation of a ternary complex between PROTAC, ligase, and the protein of inte
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Tackle the high-hanging fruits in challenging drug discovery pipelines
There are a number of interesting drug targets that have a reputation of being especially difficult to study in biochemical or biophysical assays. Join us to learn how Dianthus can help you address t
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Tackle undruggable targets by screening for binary and ternary PROTAC interactions using Dianthus
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Sweet and blind spots in E3 ligase ligand space revealed by a thermophoresis-based assay
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PROTACs: the game-changing technology that promises to tackle “undruggable” proteins
Almost all pharmaceutical drugs today act by binding to disease-causing proteins and inhibiting their activity. Unfortunately, there are still many target proteins — as much as 85% of the human...
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Targeting the SARS-CoV‑2 RNA genome with small molecule binders and ribonuclease targeting chimera (RIBOTAC) degraders
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Targeted degradation of a hypoxia-associated non-coding RNA enhances the selectivity of a small molecule interacting with RNA
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The peptide PROTAC modality: a novel strategy for targeted protein ubiquitination
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A cell-permeable peptide-based PROTAC against the oncoprotein CREPT proficiently inhibits pancreatic cancer
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