Application Notes

Proximity Inducers in Drug Discovery - A Perspective on Cooperativity

Achieve Highly Sensitive and Precise Binding Affinity Measurements Without Disrupting Protein Conformation

How Pierre Fabre Laboratories enhances their antibody developability platform

Learn how Pierre Fabre uses multi-parameter stability measurements of mAb libraries on Prometheus Panta to streamline developability platforms, reducing complexity, cost, and sample consumption.

Optimization of membrane proteins for cryo-EM: Screening of copolymer nanodiscs with Prometheus Panta

Membrane proteins present challenges for structural analysis by cryo-EM; Screening of synthetic copolymers with nanoDSF and DLS on Prometheus Panta help select the best solubilization conditions.

How Merck KGaA uses light scattering measurements for better developability assessment of biologic therapeutics

Biologics developability: learn how Merck uses Prometheus Panta to create developability profiles for their mAbs

MST untangles the intricacy of a multimeric protein complex in its native form

Quantifying oligonucleotides binding to human serum albumin with MST: A faster and precise approach for drug candidates ADME profiling

Fast molecular interaction screening of epigenetic gene regulator G9a with fragments from a large chemical space

Rapid Quantification of Unfolded Proteins for Quality Control and Optimization of Storage Conditions

Fast and accurate evaluation of oxidation-induced destabilization of mAbs

Protein labeling – improved quantitation of biomolecular interactions by MST using the RED-NHS 2nd generation labeling kit

Purification-free labeling in whole cell lysate and binding characterization by MST

Determination of low-picomolar affinities of sgRNAs and crRNA/tracrRNAs for Cas9

One-step, purification-free and site-specific labeling of polyhistidine-tagged proteins for MST

Interaction of maltose binding protein (MBP) with maltose in a truly label-free assay

Studying the interaction of the antibody-drug conjugate SYD985 with an anti-toxin antibody

Anaerobic MicroScale Thermophoresis reveals the redox dependency of ferredoxin in mitochondrial Fe/S biogenesis

Studying the interaction of membrane enzyme PgIB with substrate and inhibitory peptide