Application Notes

  • How Merck KGaA uses light scattering measurements for better developability assessment of biologic therapeutics

    How Merck KGaA uses light scattering measurements for better developability assessment of biologic therapeutics

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  • Stability optimization of engineered mAbs

    Stability optimization of engineered mAbs

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  • MST untangles the intricacy of a multimeric protein complex in its native form

    MST untangles the intricacy of a multimeric protein complex in its native form

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  • Quantifying oligonucleotides binding to human serum albumin with MST: A faster and precise approach for drug candidates ADME profiling

    Quantifying oligonucleotides binding to human serum albumin with MST: A faster and precise approach for drug candidates ADME profiling

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  • Fast molecular interaction screening of epigenetic gene regulator G9a with fragments from a large chemical space

    Fast molecular interaction screening of epigenetic gene regulator G9a with fragments from a large chemical space

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  • Rapid Quantification of Unfolded Proteins for Quality Control and Optimization of Storage Conditions

    Rapid Quantification of Unfolded Proteins for Quality Control and Optimization of Storage Conditions

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  • Fast and accurate evaluation of oxidation-induced destabilization of mAbs

    Fast and accurate evaluation of oxidation-induced destabilization of mAbs

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  • Protein labeling – improved quantitation of biomolecular interactions by MST using the RED-NHS 2nd generation labeling kit

    Protein labeling – improved quantitation of biomolecular interactions by MST using the RED-NHS 2nd generation labeling kit

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  • Purification-free labeling in whole cell lysate and binding characterization by MST

    Purification-free labeling in whole cell lysate and binding characterization by MST

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  • Determination of low-picomolar affinities of sgRNAs and crRNA/tracrRNAs for Cas9

    Determination of low-picomolar affinities of sgRNAs and crRNA/tracrRNAs for Cas9

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  • One-step, purification-free and site-specific labeling of polyhistidine-tagged proteins for MST

    One-step, purification-free and site-specific labeling of polyhistidine-tagged proteins for MST

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  • Interaction of maltose binding protein (MBP) with maltose in a truly label-free assay

    Interaction of maltose binding protein (MBP) with maltose in a truly label-free assay

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  • Studying the interaction of the antibody-drug conjugate SYD985 with an anti-toxin antibody

    Studying the interaction of the antibody-drug conjugate SYD985 with an anti-toxin antibody

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  • Anaerobic MicroScale Thermophoresis reveals the redox dependency of ferredoxin in mitochondrial Fe/S biogenesis

    Anaerobic MicroScale Thermophoresis reveals the redox dependency of ferredoxin in mitochondrial Fe/S biogenesis

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  • Studying the interaction of membrane enzyme PgIB with substrate and inhibitory peptide

    Studying the interaction of membrane enzyme PgIB with substrate and inhibitory peptide

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  • Analyzing the binding affinity of aptamer quantum dot conjugates to VEGF

    Analyzing the binding affinity of aptamer quantum dot conjugates to VEGF

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  • Thermodynamic characterization of DNA hybridization

    Thermodynamic characterization of DNA hybridization

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  • The decondensation factor 31 binds to mono-nucleosomes

    The decondensation factor 31 binds to mono-nucleosomes

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  • The decondensation factor 31 specifically binds to ssRNA but not to ssDNA or dsDNA

    The decondensation factor 31 specifically binds to ssRNA but not to ssDNA or dsDNA

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  • The decondensation factor 31 specifically interacts with histones H3 and H4 but not H2A and H2B

    The decondensation factor 31 specifically interacts with histones H3 and H4 but not H2A and H2B

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