Prometheus Publications

  • Multi-parameter formulation development for an HIV-vaccine protein with direct validation of epitope binding integrity and stoichiometry

    Multi-parameter formulation development for an HIV-vaccine protein with direct validation of epitope binding integrity and stoichiometry

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  • Stability liabilities of biotherapeutic proteins: Early assessment as mitigation strategy

    Stability liabilities of biotherapeutic proteins: Early assessment as mitigation strategy

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  • Predicting antibody developability profiles through early stage discovery screening

    Predicting antibody developability profiles through early stage discovery screening

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  • In pursuit of stability enhancement of a prostate cancer targeting antibody derived from a transgenic animal platform

    In pursuit of stability enhancement of a prostate cancer targeting antibody derived from a transgenic animal platform

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  • Peptide-MHC I complex stability measured by nanoscale differential scanning fluorimetry reveals molecular mechanism of thermal denaturation

    Peptide-MHC I complex stability measured by nanoscale differential scanning fluorimetry reveals molecular mechanism of thermal denaturation

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  • Understanding unfolding and refolding of the antibody fragment (Fab). I. In-vitro study

    Understanding unfolding and refolding of the antibody fragment (Fab). I. In-vitro study

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  • An application of nano differential scanning fluorimetry for higher order structure assessment between mAb originator and biosimilars

    An application of nano differential scanning fluorimetry for higher order structure assessment between mAb originator and biosimilars

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  • Stepwise conformational stabilization of a HIV-1 clade C consensus envelope trimer immunogen impacts vaccine-induced antibody responses

    Stepwise conformational stabilization of a HIV-1 clade C consensus envelope trimer immunogen impacts vaccine-induced antibody responses

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  • Rapid development of SARS-CoV-2 spike protein receptor-binding domain self-assembled nanoparticle vaccine candidates

    Rapid development of SARS-CoV-2 spike protein receptor-binding domain self-assembled nanoparticle vaccine candidates

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  • Thermodynamics of amyloid fibril formation from non-equilibrium experiments of growth and dissociation

    Thermodynamics of amyloid fibril formation from non-equilibrium experiments of growth and dissociation

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  • Methods Matter: Standard production platforms for recombinant AAV produce chemically and functionally distinct vectors

    Methods Matter: Standard production platforms for recombinant AAV produce chemically and functionally distinct vectors

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  • Quantitation of trace levels of DNA released from disrupted Adeno-associated virus gene therapy vectors

    Quantitation of trace levels of DNA released from disrupted Adeno-associated virus gene therapy vectors

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  • Understanding the process-induced formation of minorconformational variants of Erwinia chrysanthemi L-asparaginase

    Understanding the process-induced formation of minorconformational variants of Erwinia chrysanthemi L-asparaginase

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  • Exploring chemical space for new substances to stabilize a therapeutic monoclonal antibody

    Exploring chemical space for new substances to stabilize a therapeutic monoclonal antibody

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  • nanoDSF as screening tool for enzyme libraries and biotechnology development

    nanoDSF as screening tool for enzyme libraries and biotechnology development

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  • An AI-powered blood test to detect cancer using nanoDSF

    An AI-powered blood test to detect cancer using nanoDSF

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  • Saposin lipid nanoparticles: A highly versatile and modular tool for membrane protein research

    Saposin lipid nanoparticles: A highly versatile and modular tool for membrane protein research

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  • Structure of DtpA from E. coli in complex with Valganciclovir provides insights into drug binding of human PepT1

    Structure of DtpA from E. coli in complex with Valganciclovir provides insights into drug binding of human PepT1

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  • Structural basis of species-selective antagonist binding to the succinate receptor

    Structural basis of species-selective antagonist binding to the succinate receptor

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  • Towards high throughput GPCR crystallography: In Meso soaking of Adenosine A2A Receptor crystals

    Towards high throughput GPCR crystallography: In Meso soaking of Adenosine A2A Receptor crystals

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