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  • Thermal stability measurements for biologics developability profiling24:28

    Thermal stability measurements for biologics developability profiling

    Learn about four methods for thermal stability measurements: DSC, CD, DSF and nanoDSF. You'll review their pros and cons, what they data tell you and why it's important for biologics developability.

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  • Selective degradation of cancer target WDR5 — Evaluation of PROTACs binary and ternary affinities with Spectral Shift22:23

    Selective degradation of cancer target WDR5 — Evaluation of PROTACs binary and ternary affinities with Spectral Shift

    Chances are your company’s research and development pipeline includes several PROTAC candidates — placing you with many others in the race to bring successful and efficient protein degraders to the cl

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  • Learn the pros and cons of 4 methods to assess the thermal stability of your therapeutic proteins

    Learn the pros and cons of 4 methods to assess the thermal stability of your therapeutic proteins

    Learn about Differential Scanning Calorimetry (DSC), Circular Dichroism (CD), Extrinsic Differential Scanning Fluorimetry, and nano-Differential Scanning Fluorimetry for thermal stability of proteins

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  • Explore Prometheus Panta – Frequently asked questions about stability profiling experiments8:38

    Explore Prometheus Panta – Frequently asked questions about stability profiling experiments

    In this video, Nathan Wallace, Application Specialist at NanoTemper, addresses common questions about experimental design for developability profiling and the operation of Prometheus Panta.

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  • Explore Prometheus Panta – Biologics developability assessment with four integrated technologies20:19

    Explore Prometheus Panta – Biologics developability assessment with four integrated technologies

    Developability assessment is a critical part of the evaluation and selection of candidates for further optimization and development for biologics researchers. This work entails collecting, ranking, an

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  • Stability assessment of biologics during early development workflows

    Stability assessment of biologics during early development workflows

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  • How to keep your degrader pipeline moving forward with Dianthus16:42

    How to keep your degrader pipeline moving forward with Dianthus

    The development of your protein degrader is a multi-step and complex process usually packed with challenges that if left unsolved will delay the progress of your project. What if you could overcome co

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  • How stability characterization parameters help you create biologics developability profiles

    How stability characterization parameters help you create biologics developability profiles

    Developability profiles help you avoid risk by collecting many quality attributes associated with each candidate, enabling you to rank each candidate by the most optimal attributes and make a...

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  • How biologics teams approach developability screening of their candidates with combinatorial stability characterization21:31

    How biologics teams approach developability screening of their candidates with combinatorial stability characterization

    Full developability profiles de-risk the selection process for biologics candidates during early development workflows. There are many critical quality attributes to evaluate when it comes to developa

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  • Use light-scattering techniques to predict how your early development candidates will behave at high concentrations for the clinic

    Use light-scattering techniques to predict how your early development candidates will behave at high concentrations for the clinic

    Self-association, or the tendency for a molecule to be attracted to itself, is an important assessment criterium for those concerned about how their biologic will behave in the clinic. Researchers...

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  • How to use light scattering techniques to predict your biologic’s self-association behavior at high concentrations17:33

    How to use light scattering techniques to predict your biologic’s self-association behavior at high concentrations

    Developability work requires the assessment of multiple critical quality attributes (CQAs) of your biologics. Many of these CQAs are measured or monitored using low-volume, low-concentration samples.

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  • The biologics researcher's mini-guide to screening candidates with nanoDSF

    The biologics researcher's mini-guide to screening candidates with nanoDSF

    Read this nanoDSF guide to learn how nano-Differential Scanning Fluorimetry (nanoDSF) uses your protein’s intrinsic fluorescence to determine its melting temperature, Tm and onset of melting, Ton.

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  • What to consider when adding DLS to your early biologics development workflow (FAQs and practical tips)

    What to consider when adding DLS to your early biologics development workflow (FAQs and practical tips)

    Dynamic Light Scattering (DLS) is a versatile and simple tool used ‌for assessing the colloidal stability of drug candidates early in protein-based therapeutic development. Like any tool or...

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  • How biologics teams use Dynamic Light Scattering to identify leading candidates13:12

    How biologics teams use Dynamic Light Scattering to identify leading candidates

    Watch this 15 min video to learn how groups in early biologics development and formulation use Dynamic Light Scattering (DLS) to make informed decisions that de-risk downstream biologics development.

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  • Top 8 targeted protein degradation conferences of 2023 at a glance

    Top 8 targeted protein degradation conferences of 2023 at a glance

    Use this downloadable list of 2023 Targeted Protein Degradation conferences to choose which one(s) to attend. Learn when and where they’ll happen, who’ll be there, and the main focus.

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  • How early discovery and development teams use Dynamic Light Scattering to de⁠-⁠risk downstream biologics development

    How early discovery and development teams use Dynamic Light Scattering to de⁠-⁠risk downstream biologics development

    As a discovery or early development scientist, you’re tasked with identifying the most promising biologics candidates. Your hard work during early development enables straightforward and efficient...

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  • 8 Targeted Protein Degradation conferences in 2023 you won’t want to miss

    8 Targeted Protein Degradation conferences in 2023 you won’t want to miss

    2023 is expected to be a year of big announcements in the targeted protein degradation (TPD) therapeutics space. With more than 20 degraders in clinical trials, many decisions are coming. The race...

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  • Top 8 biologics conferences of 2023 at a glance

    Top 8 biologics conferences of 2023 at a glance

    Use this downloadable list of 2023 biologics conferences to select which one to attend. Learn when and where they’ll happen, who’ll be there, and the main focus.

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  • Four integrated technologies for Biologics developability assessment4:51

    Four integrated technologies for Biologics developability assessment

    The decisions you make about your biologics candidates early in the pipeline ultimately affect their success as therapeutics. Combine sizing and stability information to develop successful biologics

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  • How Coriolis Pharma screens a vast chemical library for stabilizing excipients1:39

    How Coriolis Pharma screens a vast chemical library for stabilizing excipients

    Discover how Coriolis Pharma found the best excipients to stabilize their monoclonal antibodies for long-term storage. You’ll learn about the importance of expanding the chemical space for excipients

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