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  • What is Dynamic Light Scattering (and 4 reasons it’s useful for protein research)

    What is Dynamic Light Scattering (and 4 reasons it’s useful for protein research)

    Any researcher looking to better understand their protein’s behavior can benefit from the information provided by Dynamic Light Scattering (DLS). Here’s an overview of DLS and how it’s useful for...

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  • Mischievous membrane proteins (and how to tame them)25:40

    Mischievous membrane proteins (and how to tame them)

    Are you struggling to tame your mischievous membrane proteins? Find out how NanoTemper can help you to characterize even the most challenging membrane protein samples. You will learn how Prometheus ca

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  • Measure binding affinities for any type of interaction — examine a label-free or labeled target molecule at anytime

    Measure binding affinities for any type of interaction — examine a label-free or labeled target molecule at anytime

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  • Potent neutralization of clinical isolates of SARS-CoV-2 D614 and G614 variants by a monomeric, sub-nanomolar affinity nanobody

    Potent neutralization of clinical isolates of SARS-CoV-2 D614 and G614 variants by a monomeric, sub-nanomolar affinity nanobody

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  • Optimizing stability during the formulation of therapeutic proteins12:14

    Optimizing stability during the formulation of therapeutic proteins

    Monoclonal antibodies and therapeutic proteins for vaccines require extensive stability characterization during their development phase to improve their probability of successful treatment. We will di

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  • How to plan for the next steps after your grant submission

    How to plan for the next steps after your grant submission

    Federal grants serve as the bread and butter for funding most, if not all, academic research labs. To write grant proposals and finally submit them is no trivial task. These generally take months...

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  • Can bioanalytical tools solve your neurodegenerative disease research challenges? 4 questions to ask yourself

    Can bioanalytical tools solve your neurodegenerative disease research challenges? 4 questions to ask yourself

    Despite extensive efforts, neurodegenerative diseases (ND) continue to feel like a pharmaceutical frontier. We have yet to see any effective drugs for conditions such as Alzheimer’s, Parkinson’s,...

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  • 3 case studies on how to characterize challenging drug discovery targets — membrane proteins, peptide libraries, and PROTACs

    3 case studies on how to characterize challenging drug discovery targets — membrane proteins, peptide libraries, and PROTACs

    A caveat to a successful pharmaceutical industry in which many effective drugs have already been discovered is the notion that the high hanging fruits left unpicked come in the form of challenging...

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  • Understanding the nuances of targeted protein degradation59:35

    Understanding the nuances of targeted protein degradation

    Bifunctional degrader molecules (also known as PROTACs) and molecular glues recruit proteins to E3 ubiquitin ligases. The formation of a ternary complex between PROTAC, ligase, and the protein of inte

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  • High-throughput determination of protein affinities using unmodified peptide libraries in nanomolar scale

    High-throughput determination of protein affinities using unmodified peptide libraries in nanomolar scale

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  • Sweet and blind spots in E3 ligase ligand space revealed by a thermophoresis-based assay

    Sweet and blind spots in E3 ligase ligand space revealed by a thermophoresis-based assay

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  • How Amgen looks at stability characterization to boost the success of biologics candidates

    How Amgen looks at stability characterization to boost the success of biologics candidates

    Biologic drugs have been incredibly successful in terms of both medical achievement and profitability. Many of these are recombinant proteins and antibodies that treat a myriad of conditions...

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  • Multi-parameter formulation development for an HIV-vaccine protein with direct validation of epitope binding integrity and stoichiometry

    Multi-parameter formulation development for an HIV-vaccine protein with direct validation of epitope binding integrity and stoichiometry

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  • Formulation and stability screening of biotherapeutics41:05

    Formulation and stability screening of biotherapeutics

    The stability of biopharmaceuticals is a complex mixture of parameters and plays a crucial role throughout the entire product lifecycle, from discovery through production and manufacturing. Making cri

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  • Sizing accuracy and intra-assay precision of DLS measurements with Prometheus Panta

    Sizing accuracy and intra-assay precision of DLS measurements with Prometheus Panta

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  • Tackle undruggable targets by screening for binary and ternary PROTAC interactions using Dianthus

    Tackle undruggable targets by screening for binary and ternary PROTAC interactions using Dianthus

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  • The NanoTemper Story – Chapter 6: The Prometheus Panta

    The NanoTemper Story – Chapter 6: The Prometheus Panta

    Take a moment to consider what it would have been like to be a researcher in your field a hundred, fifty, or even twenty years ago. The technology that enables us to make scientific progress is...

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  • Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2

    Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2

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  • What to consider before accepting an offer to start your lab

    What to consider before accepting an offer to start your lab

    Starting your own lab is a very exciting and rewarding opportunity. And, even if you are still early in your research career but are considering becoming a PI in the future, it wouldn’t hurt to...

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  • How to convince researchers to join your new lab (over more established ones)

    How to convince researchers to join your new lab (over more established ones)

    Starting a new lab as a principal investigator is an exhilarating endeavor. However, you’re met with an immediate challenge: you have to recruit new members to your lab. Potential members of your...

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