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  • 5 biologics conferences you won’t want to miss in 2024

    5 biologics conferences you won’t want to miss in 2024

    Use this list of crowd-sourced favorites to kick-start your 2024 biologics conference plans. Find out when and where each conference takes place, who will be there, which topics are covered, and...

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  • Attend these targeted protein degradation conferences in 2024 to stay in the know

    Attend these targeted protein degradation conferences in 2024 to stay in the know

    Attending dedicated targeted protein degradation conferences and tracks is a great way to keep up with this rapidly evolving field. Here are 8 conferences you’ll want to attend in 2024.

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  • The use of Spectral Shift in identifying Microcycle® hits for challenging therapeutic targets14:18

    The use of Spectral Shift in identifying Microcycle® hits for challenging therapeutic targets

    Transcription factors have traditionally been considered challenging therapeutic targets. Their intrinsic disorder and lack of small molecule binding pockets make them intractable to small molecule ap

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  • Screening for p38 ligands: From assay optimization to lead validation in 2 days12:54

    Screening for p38 ligands: From assay optimization to lead validation in 2 days

    Dianthus is a biophysical screening instrument that uses Spectral Shift technology to measure molecular interactions for hit ID, hit-to-lead, and lead optimization. It offers a 384-well plate format a

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  • Applying Spectral Shift technology to study IDPs: Direct binding and displacement assays of MYC:MAX inhibitors11:48

    Applying Spectral Shift technology to study IDPs: Direct binding and displacement assays of MYC:MAX inhibitors

    MYC is an important therapeutic target that associates with MAX to regulate gene transcription. Its lack of binding pockets and the presence of disordered regions make it a difficult protein to study

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  • De-risk your ADC development process with these stability considerations

    De-risk your ADC development process with these stability considerations

    Antibody-drug conjugates, or ADCs, are revolutionary therapeutics that represent a growing proportion of the biologics market. They combine the targeting power of a monoclonal antibody, which is...

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  • Conversation:  How Aaron Frimel from Thermo Fisher Scientific approaches biologics formulation38:20

    Conversation: How Aaron Frimel from Thermo Fisher Scientific approaches biologics formulation

    Join this conversation to gain insight into how the Analytical and Formulation Sciences team at Thermo Fisher Scientific approaches stability assessment of biologic, and how the Prometheus Panta helps

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  • Direct comparison of binding affinities from Spectral Shift and SPR for biotinylated targets

    Direct comparison of binding affinities from Spectral Shift and SPR for biotinylated targets

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  • How to mitigate risk during ADC development with multi-parameter stability characterization19:16

    How to mitigate risk during ADC development with multi-parameter stability characterization

    To assess the developability properties of antibody-drug conjugates (ADCs) learn about multi-parameter characterization of thermal and colloidal stability with Prometheus Panta using nanoDSF and DLS

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  • nanoDSF for biologics: How to interpret thermal unfolding profiles for your different applications38:31

    nanoDSF for biologics: How to interpret thermal unfolding profiles for your different applications

    Thermal stability screening is a common approach used to study the developability of a wide range of protein-based therapeutics. Among the different technologies available to perform thermal stability

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  • Thermal stability measurements for biologics developability profiling24:28

    Thermal stability measurements for biologics developability profiling

    Learn about four methods for thermal stability measurements: DSC, CD, DSF and nanoDSF. You'll review their pros and cons, what they data tell you and why it's important for biologics developability.

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  • Selective degradation of cancer target WDR5 — Evaluation of PROTACs binary and ternary affinities with Spectral Shift22:23

    Selective degradation of cancer target WDR5 — Evaluation of PROTACs binary and ternary affinities with Spectral Shift

    Chances are your company’s research and development pipeline includes several PROTAC candidates — placing you with many others in the race to bring successful and efficient protein degraders to the cl

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  • Why nanoDSF is the preferred method to assess the thermal stability of your therapeutic proteins

    Why nanoDSF is the preferred method to assess the thermal stability of your therapeutic proteins

    Learn about Differential Scanning Calorimetry (DSC), Circular Dichroism (CD), Extrinsic Differential Scanning Fluorimetry, and nano-Differential Scanning Fluorimetry for thermal stability of proteins

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  • Explore Prometheus Panta – Frequently asked questions about stability profiling experiments8:38

    Explore Prometheus Panta – Frequently asked questions about stability profiling experiments

    In this video, Nathan Wallace, Application Specialist at NanoTemper, addresses common questions about experimental design for developability profiling and the operation of Prometheus Panta.

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  • Explore Prometheus Panta – Biologics developability assessment with four integrated technologies20:19

    Explore Prometheus Panta – Biologics developability assessment with four integrated technologies

    Developability assessment is a critical part of the evaluation and selection of candidates for further optimization and development for biologics researchers. This work entails collecting, ranking, an

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  • How four stability assessment technologies support biologics early development

    How four stability assessment technologies support biologics early development

    During early development of biologics, there are many attributes scientists evaluate for developability. Measure them with biophysical characterization using nanoDSF, DLS, backreflection, and SLS.

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  • How to keep your degrader pipeline moving forward with Dianthus16:42

    How to keep your degrader pipeline moving forward with Dianthus

    The development of your protein degrader is a multi-step and complex process usually packed with challenges that if left unsolved will delay the progress of your project. What if you could overcome co

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  • How stability characterization parameters help you create biologics developability profiles

    How stability characterization parameters help you create biologics developability profiles

    Developability profiles help you avoid risk by collecting many quality attributes associated with each candidate, enabling you to rank each candidate by the most optimal attributes and make a...

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  • How biologics teams approach developability screening of their candidates with combinatorial stability characterization21:31

    How biologics teams approach developability screening of their candidates with combinatorial stability characterization

    Full developability profiles de-risk the selection process for biologics candidates during early development workflows. There are many critical quality attributes to evaluate when it comes to developa

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  • Use light-scattering techniques to predict how your early development candidates will behave at high concentrations for the clinic

    Use light-scattering techniques to predict how your early development candidates will behave at high concentrations for the clinic

    Light scattering techniques are used to predict high-concentration behavior of candidates early in the development process. Let's take a look at what they tell you, how to set them up, and how...

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