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ReadWhat is Dynamic Light Scattering (and 4 reasons it’s useful for protein research)
Any researcher looking to better understand their protein’s behavior can benefit from the information provided by Dynamic Light Scattering (DLS). Here’s an overview of DLS and how it’s useful for...
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Dynamic Light Scattering
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25:40WatchMischievous membrane proteins (and how to tame them)
Are you struggling to tame your mischievous membrane proteins? Find out how NanoTemper can help you to characterize even the most challenging membrane protein samples. You will learn how Prometheus ca
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Measure binding affinities for any type of interaction — examine a label-free or labeled target molecule at anytime
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ReadPotent neutralization of clinical isolates of SARS-CoV-2 D614 and G614 variants by a monomeric, sub-nanomolar affinity nanobody
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12:14WatchOptimizing stability during the formulation of therapeutic proteins
Monoclonal antibodies and therapeutic proteins for vaccines require extensive stability characterization during their development phase to improve their probability of successful treatment. We will di
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ReadHow to plan for the next steps after your grant submission
Federal grants serve as the bread and butter for funding most, if not all, academic research labs. To write grant proposals and finally submit them is no trivial task. These generally take months...
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ReadCan bioanalytical tools solve your neurodegenerative disease research challenges? 4 questions to ask yourself
Despite extensive efforts, neurodegenerative diseases (ND) continue to feel like a pharmaceutical frontier. We have yet to see any effective drugs for conditions such as Alzheimer’s, Parkinson’s,...
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Read3 case studies on how to characterize challenging drug discovery targets — membrane proteins, peptide libraries, and PROTACs
A caveat to a successful pharmaceutical industry in which many effective drugs have already been discovered is the notion that the high hanging fruits left unpicked come in the form of challenging...
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59:35WatchUnderstanding the nuances of targeted protein degradation
Bifunctional degrader molecules (also known as PROTACs) and molecular glues recruit proteins to E3 ubiquitin ligases. The formation of a ternary complex between PROTAC, ligase, and the protein of inte
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ReadHigh-throughput determination of protein affinities using unmodified peptide libraries in nanomolar scale
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ReadSweet and blind spots in E3 ligase ligand space revealed by a thermophoresis-based assay
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ReadHow Amgen looks at stability characterization to boost the success of biologics candidates
Biologic drugs have been incredibly successful in terms of both medical achievement and profitability. Many of these are recombinant proteins and antibodies that treat a myriad of conditions...
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ReadMulti-parameter formulation development for an HIV-vaccine protein with direct validation of epitope binding integrity and stoichiometry
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41:05WatchFormulation and stability screening of biotherapeutics
The stability of biopharmaceuticals is a complex mixture of parameters and plays a crucial role throughout the entire product lifecycle, from discovery through production and manufacturing. Making cri
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Sizing accuracy and intra-assay precision of DLS measurements with Prometheus Panta
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Tackle undruggable targets by screening for binary and ternary PROTAC interactions using Dianthus
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ReadThe NanoTemper Story – Chapter 6: The Prometheus Panta
Take a moment to consider what it would have been like to be a researcher in your field a hundred, fifty, or even twenty years ago. The technology that enables us to make scientific progress is...
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ReadSelection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2
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ReadWhat to consider before accepting an offer to start your lab
Starting your own lab is a very exciting and rewarding opportunity. And, even if you are still early in your research career but are considering becoming a PI in the future, it wouldn’t hurt to...
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ReadHow to convince researchers to join your new lab (over more established ones)
Starting a new lab as a principal investigator is an exhilarating endeavor. However, you’re met with an immediate challenge: you have to recruit new members to your lab. Potential members of your...
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