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  • Use of self-interaction parameters derived from light scattering experiments for better developability assessment of biologic therapeutics

    Use of self-interaction parameters derived from light scattering experiments for better developability assessment of biologic therapeutics

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  • How do you get reproducible data from protein characterization experiments? Try following this DIN SPEC

    How do you get reproducible data from protein characterization experiments? Try following this DIN SPEC

    Reproducibility is a key tenet of scientific research, but many pharma groups have projects that collaborate across different sites or that rely on materials prepared by other specialist...

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  • How to improve outcomes of your viral vectors for gene therapy with high-quality data from biophysical profiling methods21:48

    How to improve outcomes of your viral vectors for gene therapy with high-quality data from biophysical profiling methods

    Optimizing your vectors for gene therapy is a daunting task. When developing and optimizing AAVs, concerns such as serotype, storage stability, expression method, and genetic fill level must be addres

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  • Overcome bottlenecks in viral vector manufacturing25:08

    Overcome bottlenecks in viral vector manufacturing

    The success of your gene therapy vectors is dependent on optimal formulation conditions. Finding a buffer that provides better long-term stability for AAVs is a crucial step in the process of developi

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  • Stability optimization of engineered mAbs

    Stability optimization of engineered mAbs

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  • Analyze self-interaction to predict viscosity and aggregation propensity at higher concentrations

    Analyze self-interaction to predict viscosity and aggregation propensity at higher concentrations

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  • For protein degraders to tackle neurodegenerative diseases, these are the barriers they need to overcome

    For protein degraders to tackle neurodegenerative diseases, these are the barriers they need to overcome

    Neurodegenerative diseases (ND) and cancer are the two major targets in the pipelines of companies focused on targeted protein degradation as a therapeutic modality. Proteins involved in NDs —...

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  • Tour Andromeda: how to screen for optimal expression of folded membrane proteins in crude lysate32:05

    Tour Andromeda: how to screen for optimal expression of folded membrane proteins in crude lysate

    Poor expression levels, solubilization, and stability — these are the daily challenges that your membrane protein production team faces every day. You go through long cycles of expression optimization

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  • The autocorrelation function: the key to understanding your biological molecules25:16

    The autocorrelation function: the key to understanding your biological molecules

    Dynamic Light Scattering (DLS) is a technique that allows researchers to accurately size their biologic molecules and determine the distribution of particle sizes in a solution. In order to turn scatt

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  • How to find promising small molecule lead compounds with biophysical tools25:01

    How to find promising small molecule lead compounds with biophysical tools

    Watch this webinar if you’re working in the field of small molecule drug discovery and want to learn how scientists in this field use biophysical tools to search for the most promising lead compounds.

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  • Why so many companies are betting on PROTACs as a superior therapeutic modality

    Why so many companies are betting on PROTACs as a superior therapeutic modality

    With PROTACs currently in the clinical and preclinical stages, they are making exciting progress towards successfully treating patients who have been waiting for effective therapies for certain...

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  • Peptide-MHC I complex stability measured by nanoscale differential scanning fluorimetry reveals molecular mechanism of thermal denaturation

    Peptide-MHC I complex stability measured by nanoscale differential scanning fluorimetry reveals molecular mechanism of thermal denaturation

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  • MST and TRIC technology to reliably study PROTAC binary and ternary binding in drug development

    MST and TRIC technology to reliably study PROTAC binary and ternary binding in drug development

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  • Use of high-throughput methods for early stage formulation evaluation and their correlation to stability studies28:21

    Use of high-throughput methods for early stage formulation evaluation and their correlation to stability studies

    AbbVie preformulation is an early discovery biologics group working to optimise antibodies prior to downstream assays and clinical delivery. Join Brittney Mills, PhD, as she explains how AbbVie uses

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  • How to study molecular interactions of membrane proteins without compromising their native structure14:01

    How to study molecular interactions of membrane proteins without compromising their native structure

    The desire to use technology that allows you to study membrane proteins in close-to-native conditions is specifically important when it comes to interaction measurements. It’s always a question how mu

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  • How to find expression and purification conditions that result in high levels of thermally stable membrane proteins12:06

    How to find expression and purification conditions that result in high levels of thermally stable membrane proteins

    What you’ll learn It’s very common to experience low expression levels when producing membrane proteins — plus they’re finicky and unstable when they're outside of their native environment. Just know

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  • 5 formulation changes you can evaluate with Dynamic Light Scattering to increase your biologics candidates’ success

    5 formulation changes you can evaluate with Dynamic Light Scattering to increase your biologics candidates’ success

    Biologics researchers are deeply concerned with formulation. Formulation typically refers to the final development of a deliverable, biologically derived molecule (such as a protein, peptide,...

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  • The biologics researcher's guide to DLS

    The biologics researcher's guide to DLS

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  • NanoTemper gets Top 100 award as one of Germany’s most innovative SMEs in 2021

    NanoTemper gets Top 100 award as one of Germany’s most innovative SMEs in 2021

    NanoTemper has been given this year’s TOP 100 seal, an award that honors innovative German small and medium-sized companies. The TOP 100 innovation competition is organized by compamedia, and...

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  • Fast Mek1 hit identification with TRIC technology correlates well with other biophysical methods

    Fast Mek1 hit identification with TRIC technology correlates well with other biophysical methods

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