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Use of self-interaction parameters derived from light scattering experiments for better developability assessment of biologic therapeutics
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ReadHow do you get reproducible data from protein characterization experiments? Try following this DIN SPEC
Reproducibility is a key tenet of scientific research, but many pharma groups have projects that collaborate across different sites or that rely on materials prepared by other specialist...
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21:48WatchHow to improve outcomes of your viral vectors for gene therapy with high-quality data from biophysical profiling methods
Optimizing your vectors for gene therapy is a daunting task. When developing and optimizing AAVs, concerns such as serotype, storage stability, expression method, and genetic fill level must be addres
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25:08WatchOvercome bottlenecks in viral vector manufacturing
The success of your gene therapy vectors is dependent on optimal formulation conditions. Finding a buffer that provides better long-term stability for AAVs is a crucial step in the process of developi
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Stability optimization of engineered mAbs
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Analyze self-interaction to predict viscosity and aggregation propensity at higher concentrations
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ReadFor protein degraders to tackle neurodegenerative diseases, these are the barriers they need to overcome
Neurodegenerative diseases (ND) and cancer are the two major targets in the pipelines of companies focused on targeted protein degradation as a therapeutic modality. Proteins involved in NDs —...
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32:05WatchTour Andromeda: how to screen for optimal expression of folded membrane proteins in crude lysate
Poor expression levels, solubilization, and stability — these are the daily challenges that your membrane protein production team faces every day. You go through long cycles of expression optimization
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25:16WatchThe autocorrelation function: the key to understanding your biological molecules
Dynamic Light Scattering (DLS) is a technique that allows researchers to accurately size their biologic molecules and determine the distribution of particle sizes in a solution. In order to turn scatt
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25:01WatchHow to find promising small molecule lead compounds with biophysical tools
Watch this webinar if you’re working in the field of small molecule drug discovery and want to learn how scientists in this field use biophysical tools to search for the most promising lead compounds.
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ReadWhy so many companies are betting on PROTACs as a superior therapeutic modality
With PROTACs currently in the clinical and preclinical stages, they are making exciting progress towards successfully treating patients who have been waiting for effective therapies for certain...
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ReadPeptide-MHC I complex stability measured by nanoscale differential scanning fluorimetry reveals molecular mechanism of thermal denaturation
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ReadMST and TRIC technology to reliably study PROTAC binary and ternary binding in drug development
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28:21WatchUse of high-throughput methods for early stage formulation evaluation and their correlation to stability studies
AbbVie preformulation is an early discovery biologics group working to optimise antibodies prior to downstream assays and clinical delivery. Join Brittney Mills, PhD, as she explains how AbbVie uses
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14:01WatchHow to study molecular interactions of membrane proteins without compromising their native structure
The desire to use technology that allows you to study membrane proteins in close-to-native conditions is specifically important when it comes to interaction measurements. It’s always a question how mu
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12:06WatchHow to find expression and purification conditions that result in high levels of thermally stable membrane proteins
What you’ll learn It’s very common to experience low expression levels when producing membrane proteins — plus they’re finicky and unstable when they're outside of their native environment. Just know
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Read5 formulation changes you can evaluate with Dynamic Light Scattering to increase your biologics candidates’ success
Biologics researchers are deeply concerned with formulation. Formulation typically refers to the final development of a deliverable, biologically derived molecule (such as a protein, peptide,...
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The biologics researcher's guide to DLS
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ReadNanoTemper gets Top 100 award as one of Germany’s most innovative SMEs in 2021
NanoTemper has been given this year’s TOP 100 seal, an award that honors innovative German small and medium-sized companies. The TOP 100 innovation competition is organized by compamedia, and...
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ReadFast Mek1 hit identification with TRIC technology correlates well with other biophysical methods
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