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  • Conversation:  How Aaron Frimel from Thermo Fisher Scientific approaches biologics formulation38:20

    Conversation: How Aaron Frimel from Thermo Fisher Scientific approaches biologics formulation

    Join this conversation to gain insight into how the Analytical and Formulation Sciences team at Thermo Fisher Scientific approaches stability assessment of biologic, and how the Prometheus Panta helps

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  • Direct comparison of binding affinities from Spectral Shift and SPR for biotinylated targets

    Direct comparison of binding affinities from Spectral Shift and SPR for biotinylated targets

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  • How to mitigate risk during ADC development with multi-parameter stability characterization19:16

    How to mitigate risk during ADC development with multi-parameter stability characterization

    To assess the developability properties of antibody-drug conjugates (ADCs) learn about multi-parameter characterization of thermal and colloidal stability with Prometheus Panta using nanoDSF and DLS

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  • nanoDSF for biologics: How to interpret thermal unfolding profiles for your different applications38:31

    nanoDSF for biologics: How to interpret thermal unfolding profiles for your different applications

    Thermal stability screening is a common approach used to study the developability of a wide range of protein-based therapeutics. Among the different technologies available to perform thermal stability

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  • Thermal stability measurements for biologics developability profiling24:28

    Thermal stability measurements for biologics developability profiling

    Learn about four methods for thermal stability measurements: DSC, CD, DSF and nanoDSF. You'll review their pros and cons, what they data tell you and why it's important for biologics developability.

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  • Selective degradation of cancer target WDR5 — Evaluation of PROTACs binary and ternary affinities with Spectral Shift22:23

    Selective degradation of cancer target WDR5 — Evaluation of PROTACs binary and ternary affinities with Spectral Shift

    Chances are your company’s research and development pipeline includes several PROTAC candidates — placing you with many others in the race to bring successful and efficient protein degraders to the cl

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  • Learn the pros and cons of 4 methods to assess the thermal stability of your therapeutic proteins

    Learn the pros and cons of 4 methods to assess the thermal stability of your therapeutic proteins

    Learn about Differential Scanning Calorimetry (DSC), Circular Dichroism (CD), Extrinsic Differential Scanning Fluorimetry, and nano-Differential Scanning Fluorimetry for thermal stability of proteins

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  • Explore Prometheus Panta – Frequently asked questions about stability profiling experiments8:38

    Explore Prometheus Panta – Frequently asked questions about stability profiling experiments

    In this video, Nathan Wallace, Application Specialist at NanoTemper, addresses common questions about experimental design for developability profiling and the operation of Prometheus Panta.

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  • Explore Prometheus Panta – Biologics developability assessment with four integrated technologies20:19

    Explore Prometheus Panta – Biologics developability assessment with four integrated technologies

    Developability assessment is a critical part of the evaluation and selection of candidates for further optimization and development for biologics researchers. This work entails collecting, ranking, an

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  • How four stability assessment technologies support biologics early development

    How four stability assessment technologies support biologics early development

    During early development of biologics, there are many attributes scientists evaluate for developability. Measure them with biophysical characterization using nanoDSF, DLS, backreflection, and SLS.

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  • How to keep your degrader pipeline moving forward with Dianthus16:42

    How to keep your degrader pipeline moving forward with Dianthus

    The development of your protein degrader is a multi-step and complex process usually packed with challenges that if left unsolved will delay the progress of your project. What if you could overcome co

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  • How stability characterization parameters help you create biologics developability profiles

    How stability characterization parameters help you create biologics developability profiles

    Developability profiles help you avoid risk by collecting many quality attributes associated with each candidate, enabling you to rank each candidate by the most optimal attributes and make a...

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  • How biologics teams approach developability screening of their candidates with combinatorial stability characterization21:31

    How biologics teams approach developability screening of their candidates with combinatorial stability characterization

    Full developability profiles de-risk the selection process for biologics candidates during early development workflows. There are many critical quality attributes to evaluate when it comes to developa

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  • Use light-scattering techniques to predict how your early development candidates will behave at high concentrations for the clinic

    Use light-scattering techniques to predict how your early development candidates will behave at high concentrations for the clinic

    Light scattering techniques are used to predict high-concentration behavior of candidates early in the development process. Let's take a look at what they tell you, how to set them up, and how...

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  • How to use light scattering techniques to predict your biologic’s self-association behavior at high concentrations17:33

    How to use light scattering techniques to predict your biologic’s self-association behavior at high concentrations

    Developability work requires the assessment of multiple critical quality attributes (CQAs) of your biologics. Many of these CQAs are measured or monitored using low-volume, low-concentration samples.

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  • The biologics researcher's mini-guide to screening candidates with nanoDSF

    The biologics researcher's mini-guide to screening candidates with nanoDSF

    Read this nanoDSF guide to learn how nano-Differential Scanning Fluorimetry (nanoDSF) uses your protein’s intrinsic fluorescence to determine its melting temperature, Tm and onset of melting, Ton.

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  • What to consider when adding DLS to your early biologics development workflow (FAQs and practical tips)

    What to consider when adding DLS to your early biologics development workflow (FAQs and practical tips)

    Read on to find the answers to questions your early development scientist peers have asked about how to use DLS to design, select, and advance the most stable biologics candidates. The post What...

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  • How biologics teams use Dynamic Light Scattering to identify leading candidates13:12

    How biologics teams use Dynamic Light Scattering to identify leading candidates

    Watch this 15 min video to learn how groups in early biologics development and formulation use Dynamic Light Scattering (DLS) to make informed decisions that de-risk downstream biologics development.

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  • Top 8 targeted protein degradation conferences of 2023 at a glance

    Top 8 targeted protein degradation conferences of 2023 at a glance

    Use this downloadable list of 2023 Targeted Protein Degradation conferences to choose which one(s) to attend. Learn when and where they’ll happen, who’ll be there, and the main focus.

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  • How early discovery and development teams use Dynamic Light Scattering to de⁠-⁠risk downstream biologics development

    How early discovery and development teams use Dynamic Light Scattering to de⁠-⁠risk downstream biologics development

    As a discovery or early development scientist, you’re tasked with identifying the most promising biologics candidates. Your hard work during early development enables straightforward and...

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