Membrane Proteins

  • The power of Monolith X for Characterizing GPCRs: Accelerating Binding Affinity Measurements20:31

    The power of Monolith X for Characterizing GPCRs: Accelerating Binding Affinity Measurements

    To understand signaling pathways, Spectral Shift technology allows for accurate bindings affinity measurements of membrane proteins like GPCRs in close to native conditions.

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  • How to study molecular interactions of membrane proteins without compromising their native structure14:01

    How to study molecular interactions of membrane proteins without compromising their native structure

    The desire to use technology that allows you to study membrane proteins in close-to-native conditions is specifically important when it comes to interaction measurements. It’s always a question how mu

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  • How to find expression and purification conditions that result in high levels of thermally stable membrane proteins12:06

    How to find expression and purification conditions that result in high levels of thermally stable membrane proteins

    What you’ll learn It’s very common to experience low expression levels when producing membrane proteins — plus they’re finicky and unstable when they're outside of their native environment. Just know

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  • Working with tricky membrane proteins?

    NanoTemper tools can help

    Find out how
  • Did you say, “membrane proteins”? Challenge accepted!4:09

    Did you say, “membrane proteins”? Challenge accepted!

    Working with difficult targets like GPCRs and other membrane proteins? Because they live in the cell membrane, are hydrophobic and insoluble, have low expression levels, and require particular deter

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  • Mischievous membrane proteins (and how to tame them)25:40

    Mischievous membrane proteins (and how to tame them)

    Are you struggling to tame your mischievous membrane proteins? Find out how NanoTemper can help you to characterize even the most challenging membrane protein samples. You will learn how Prometheus ca

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  • Quantifying the interaction of phosphite with ABC transporters: MicroScale Thermophoresis and a novel his-tag labeling approach

    Quantifying the interaction of phosphite with ABC transporters: MicroScale Thermophoresis and a novel his-tag labeling approach

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  • nanoDSF: Label-free thermal unfolding assay of G Protein-coupled receptors for compound screening and buffer composition optimization

    nanoDSF: Label-free thermal unfolding assay of G Protein-coupled receptors for compound screening and buffer composition optimization

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  • Lipids activate SecA for high affinity binding to the SecYEG complex

    Lipids activate SecA for high affinity binding to the SecYEG complex

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  • Thermophoretic analysis of ligand-specific conformational states of the inhibitory glycine receptor embedded in copolymer nanodiscs

    Thermophoretic analysis of ligand-specific conformational states of the inhibitory glycine receptor embedded in copolymer nanodiscs

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  • A protein superfamily meets its match in nanoDSF

    A protein superfamily meets its match in nanoDSF

    G protein-coupled receptors (GPCRs) are the largest class of targets for drug discovery, and the fourth largest superfamily in the human genome. They have been linked to the regulation of many...

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  • Detergent-free extraction of a functional low-expressing GPCR from a human cell line

    Detergent-free extraction of a functional low-expressing GPCR from a human cell line

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  • Saposin lipid nanoparticles: A highly versatile and modular tool for membrane protein research

    Saposin lipid nanoparticles: A highly versatile and modular tool for membrane protein research

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  • Phospholipid membrane fluidity alters ligand binding activity of a G protein-coupled receptor by shifting the conformational equilibrium

    Phospholipid membrane fluidity alters ligand binding activity of a G protein-coupled receptor by shifting the conformational equilibrium

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  • Phosphorylation of human aquaporin 2 (AQP2) allosterically controls its interaction with the lysosomal trafficking protein LIP5

    Phosphorylation of human aquaporin 2 (AQP2) allosterically controls its interaction with the lysosomal trafficking protein LIP5

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  • Interactions of liposome embedded SNARE proteins

    Interactions of liposome embedded SNARE proteins

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  • Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditions

    Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditions

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  • Molecular basis of nitrate uptake by the plant nitrate transporter NRT1.1

    Molecular basis of nitrate uptake by the plant nitrate transporter NRT1.1

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  • Structure of DtpA from E. coli in complex with Valganciclovir provides insights into drug binding of human PepT1

    Structure of DtpA from E. coli in complex with Valganciclovir provides insights into drug binding of human PepT1

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  • Structural basis of species-selective antagonist binding to the succinate receptor

    Structural basis of species-selective antagonist binding to the succinate receptor

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  • Towards high throughput GPCR crystallography: In Meso soaking of Adenosine A2A Receptor crystals

    Towards high throughput GPCR crystallography: In Meso soaking of Adenosine A2A Receptor crystals

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