Membrane Proteins

  • Did you say, “membrane proteins”? Challenge accepted!4:09

    Did you say, “membrane proteins”? Challenge accepted!

    Working with difficult targets like GPCRs and other membrane proteins? Because they live in the cell membrane, are hydrophobic and insoluble, have low expression levels, and require particular deter

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  • nanoDSF: Label-free thermal unfolding assay of G Protein-coupled receptors for compound screening and buffer composition optimization

    nanoDSF: Label-free thermal unfolding assay of G Protein-coupled receptors for compound screening and buffer composition optimization

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  • Lipids activate SecA for high affinity binding to the SecYEG complex

    Lipids activate SecA for high affinity binding to the SecYEG complex

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  • Working with tricky membrane proteins?

    NanoTemper tools can help

    Find out how
  • Thermophoretic analysis of ligand-specific conformational states of the inhibitory glycine receptor embedded in copolymer nanodiscs

    Thermophoretic analysis of ligand-specific conformational states of the inhibitory glycine receptor embedded in copolymer nanodiscs

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  • Detergent-free extraction of a functional low-expressing GPCR from a human cell line

    Detergent-free extraction of a functional low-expressing GPCR from a human cell line

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  • Saposin lipid nanoparticles: A highly versatile and modular tool for membrane protein research

    Saposin lipid nanoparticles: A highly versatile and modular tool for membrane protein research

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  • Phospholipid membrane fluidity alters ligand binding activity of a G protein-coupled receptor by shifting the conformational equilibrium

    Phospholipid membrane fluidity alters ligand binding activity of a G protein-coupled receptor by shifting the conformational equilibrium

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  • Phosphorylation of human aquaporin 2 (AQP2) allosterically controls its interaction with the lysosomal trafficking protein LIP5

    Phosphorylation of human aquaporin 2 (AQP2) allosterically controls its interaction with the lysosomal trafficking protein LIP5

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  • Interactions of liposome embedded SNARE proteins

    Interactions of liposome embedded SNARE proteins

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  • Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditions

    Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditions

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  • Molecular basis of nitrate uptake by the plant nitrate transporter NRT1.1

    Molecular basis of nitrate uptake by the plant nitrate transporter NRT1.1

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  • Structure of DtpA from E. coli in complex with Valganciclovir provides insights into drug binding of human PepT1

    Structure of DtpA from E. coli in complex with Valganciclovir provides insights into drug binding of human PepT1

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  • Structural basis of species-selective antagonist binding to the succinate receptor

    Structural basis of species-selective antagonist binding to the succinate receptor

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  • Towards high throughput GPCR crystallography: In Meso soaking of Adenosine A2A Receptor crystals

    Towards high throughput GPCR crystallography: In Meso soaking of Adenosine A2A Receptor crystals

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  • Studying the interaction of membrane enzyme PgIB with substrate and inhibitory peptide

    Studying the interaction of membrane enzyme PgIB with substrate and inhibitory peptide

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  • Lipid-like peptides can stabilize integral membrane proteins for biophysical and structural studies

    Lipid-like peptides can stabilize integral membrane proteins for biophysical and structural studies

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  • Structural basis for substrate specificity and regulation of nucleotide sugar transporters in the lipid bilayer

    Structural basis for substrate specificity and regulation of nucleotide sugar transporters in the lipid bilayer

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  • Membrane (and soluble) protein stability and binding measurements in the lipid cubic phase using label-free DSF

    Membrane (and soluble) protein stability and binding measurements in the lipid cubic phase using label-free DSF

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  • nanoDSF thermal unfolding analysis of a membrane-bound esterase in various detergents

    nanoDSF thermal unfolding analysis of a membrane-bound esterase in various detergents

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  • High-throughput stability screening for detergent-solubilized membrane proteins

    High-throughput stability screening for detergent-solubilized membrane proteins

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