Membrane Proteins

Quantifying the interaction of phosphite with ABC transporters: MicroScale Thermophoresis and a novel his-tag labeling approach

Lipids activate SecA for high affinity binding to the SecYEG complex

Thermophoretic analysis of ligand-specific conformational states of the inhibitory glycine receptor embedded in copolymer nanodiscs

A protein superfamily meets its match in nanoDSF

G protein-coupled receptors (GPCRs) are the largest class of targets for drug discovery, and the fourth largest superfamily in the human genome. They have been linked to the regulation of many...

Detergent-free extraction of a functional low-expressing GPCR from a human cell line

Saposin lipid nanoparticles: A highly versatile and modular tool for membrane protein research

Phospholipid membrane fluidity alters ligand binding activity of a G protein-coupled receptor by shifting the conformational equilibrium

Phosphorylation of human aquaporin 2 (AQP2) allosterically controls its interaction with the lysosomal trafficking protein LIP5

Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditions

Molecular basis of nitrate uptake by the plant nitrate transporter NRT1.1

Structure of DtpA from E. coli in complex with Valganciclovir provides insights into drug binding of human PepT1

Structural basis of species-selective antagonist binding to the succinate receptor

Towards high throughput GPCR crystallography: In Meso soaking of Adenosine A2A Receptor crystals

Lipid-like peptides can stabilize integral membrane proteins for biophysical and structural studies