Membrane proteins, while being critical targets for drug development, present additional challenges for structural analysis; their amphipathic nature, complex architecture, as well as tedious expression and purification continue to strain researchers working with these proteins.
With the use of innovative solubilization approaches, such as synthetic copolymers and the NativeMPTM Platform, companies like Cube Biotech can more efficiently create soluble membrane proteins optimized for cryo-EM workflows to support structural biologists.
Read this Application note to learn how the application of dynamic light scattering (DLS) and nano Differential Scanning Fluorimetry (nanoDSF) provided by the Prometheus Panta helps membrane protein structural biologists rapidly find the best copolymers for their synthetic nanodiscs to ensure the highest atomic resolution for cryo-EM structures.
Learn more about Prometheus Panta in this short demo video.
