Monolith | Binding Affinity

  • See the new Monolith — characterize your most challenging interactions5:33

    See the new Monolith — characterize your most challenging interactions

    Watch
  • Because you need to characterize the most challenging interactions

    Because you need to characterize the most challenging interactions

    Read
  • The researcher’s guide to measuring binding affinity and why it matters

    The researcher’s guide to measuring binding affinity and why it matters

    Read
  • Have a question about Monolith?

    Contact Specialist
  • The peptide PROTAC modality: a novel strategy for targeted protein ubiquitination

    The peptide PROTAC modality: a novel strategy for targeted protein ubiquitination

    Read
  • Characterize the true nature of intrinsically disordered proteins without immobilizing them

    Characterize the true nature of intrinsically disordered proteins without immobilizing them

    If you study neurodegenerative diseases (ND), you already know they are one of the most challenging — and fascinating — types of diseases to study. With protein aggregation being a hallmark of ND,...

    Read
  • Scientists choose Monolith as their primary tool to measure binding interactions2:04

    Scientists choose Monolith as their primary tool to measure binding interactions

    Watch
  • A cell-permeable peptide-based PROTAC against the oncoprotein CREPT proficiently inhibits pancreatic cancer

    A cell-permeable peptide-based PROTAC against the oncoprotein CREPT proficiently inhibits pancreatic cancer

    Read
  • ×

    Sign up to receive
    the latest NanoTemper news, product updates, event announcements and more

    First Name
    Last Name
    Company Name
    Country
    State
    Province
    State
    Region
    State
    Canton
    Agree to Subscribe & Privacy Policy*
    *I have fully read, understood and agree to the Privacy Policy. I accept the storing and processing of my personal data by NanoTemper as described in the Privacy Policy.

    By completing this form, you provide us consent to contact you with educational content, news and information about our products, services and events. You may unsubscribe at any time.
    Thank you!
    Error - something went wrong!
  • Targeting the SARS-CoV‑2 RNA genome with small molecule binders and ribonuclease targeting chimera (RIBOTAC) degraders

    Targeting the SARS-CoV‑2 RNA genome with small molecule binders and ribonuclease targeting chimera (RIBOTAC) degraders

    Read
  • When binding affinity matters.

    When binding affinity matters.

    Read
  • NanoTemper debuts the newly redesigned Monolith, offering higher-quality molecular interaction measurements for very challenging targets

    NanoTemper debuts the newly redesigned Monolith, offering higher-quality molecular interaction measurements for very challenging targets

    PRESS RELEASE South San Francisco, CA. NanoTemper Technologies, well-known for creating biophysical tools that address challenging characterizations, today announced the new Monolith, redesigned...

    Read
  • Accelerate your assay development using the enhanced Binding Check module in Monolith's MO.Control 2 software

    Accelerate your assay development using the enhanced Binding Check module in Monolith's MO.Control 2 software

    Read
  • Targeted degradation of a hypoxia-associated non-coding RNA enhances the selectivity of a small molecule interacting with RNA

    Targeted degradation of a hypoxia-associated non-coding RNA enhances the selectivity of a small molecule interacting with RNA

    Read
  • Advanced features in the new Monolith

    Advanced features in the new Monolith

    Read
  • Have a question about Monolith?

    Contact Specialist
  • The NanoTemper Story – Chapter 2: The Monolith

    The NanoTemper Story – Chapter 2: The Monolith

    It’s late at night in Munich, Germany sometime in the late 2000’s. A man huddles in a dimly lit basement, painting. He paints at night after a complaint from the professors upstairs about the...

    Read
  • High-resolution structure and biophysical characterization of the nucleocapsid phosphoprotein dimerization domain from Coronavirus 2

    High-resolution structure and biophysical characterization of the nucleocapsid phosphoprotein dimerization domain from Coronavirus 2

    Read
  • The importance of molecular interactions and stability in Gene Therapy46:44

    The importance of molecular interactions and stability in Gene Therapy

    New advances in gene therapy have triggered a resurgence of interest in the field. Though gene therapy offers exciting potential for the treatment of both monogenic disorders as well as more genetical

    Watch
  • Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2

    Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2

    Read
  • Isoform-Selective ATAD2 chemical probe with novel chemical structure and unusual mode of action

    Isoform-Selective ATAD2 chemical probe with novel chemical structure and unusual mode of action

    Read
  • 4 studies highlight the impact of biophysical tools in plant science research

    4 studies highlight the impact of biophysical tools in plant science research

    Plant research paves the way for important advances in agriculture, ecology, and medicine. As an example, discoveries into plant pathogens and plant stress response lead to many incremental...

    Read
  • Trends and challenges in glycobiology: Biophysical tools to advance your molecular studies17:10

    Trends and challenges in glycobiology: Biophysical tools to advance your molecular studies

    The prominent role of glycans in biomedical research is exponentially raising as researchers discover how these sugars deeply affect protein structure and function.

    Watch
  • loading
    Loading more...