Monolith | Binding Affinity
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5:33WatchSee the new Monolith — characterize your most challenging interactions
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Because you need to characterize the most challenging interactions
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25:40WatchMischievous membrane proteins (and how to tame them)
Are you struggling to tame your mischievous membrane proteins? Find out how NanoTemper can help you to characterize even the most challenging membrane protein samples. You will learn how Prometheus ca
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Optimize the structure of your next round of PROTAC compounds by analyzing ternary binding affinities using Monolith
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The researcher’s guide to measuring binding affinity and why it matters
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Read6 protein degradation conferences in 2021 you can’t afford to miss
Conferences in 2021 will gather scientists and experts eager to discuss new discoveries in the emerging field of targeted protein degradation (TPD). Many transcription factors, scaffold proteins,...
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Measure binding affinities for any type of interaction — examine a label-free or labeled target molecule at anytime
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ReadSweet and blind spots in E3 ligase ligand space revealed by a thermophoresis-based assay
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59:35WatchUnderstanding the nuances of targeted protein degradation
Bifunctional degrader molecules (also known as PROTACs) and molecular glues recruit proteins to E3 ubiquitin ligases. The formation of a ternary complex between PROTAC, ligase, and the protein of inte
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ReadThermophoretic analysis of ligand-specific conformational states of the inhibitory glycine receptor embedded in copolymer nanodiscs
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ReadCan bioanalytical tools solve your neurodegenerative disease research challenges? 4 questions to ask yourself
Despite extensive efforts, neurodegenerative diseases (ND) continue to feel like a pharmaceutical frontier. We have yet to see any effective drugs for conditions such as Alzheimer’s, Parkinson’s,...
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ReadDetergent-free extraction of a functional low-expressing GPCR from a human cell line
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2:04WatchScientists choose Monolith as their primary tool to measure binding interactions
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ReadPhospholipid membrane fluidity alters ligand binding activity of a G protein-coupled receptor by shifting the conformational equilibrium
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ReadCharacterize the true nature of intrinsically disordered proteins without immobilizing them
If you study neurodegenerative diseases (ND), you already know they are one of the most challenging — and fascinating — types of diseases to study. With protein aggregation being a hallmark of ND,...
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ReadPhosphorylation of human aquaporin 2 (AQP2) allosterically controls its interaction with the lysosomal trafficking protein LIP5
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When binding affinity matters.
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ReadPotent neutralization of clinical isolates of SARS-CoV-2 D614 and G614 variants by a monomeric, sub-nanomolar affinity nanobody
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ReadStructure of DtpA from E. coli in complex with Valganciclovir provides insights into drug binding of human PepT1
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17:10WatchTrends and challenges in glycobiology: Biophysical tools to advance your molecular studies
The prominent role of glycans in biomedical research is exponentially raising as researchers discover how these sugars deeply affect protein structure and function.
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