Monolith | Binding Affinity

  • See the new Monolith — characterize your most challenging interactions5:33

    See the new Monolith — characterize your most challenging interactions

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  • Because you need to characterize the most challenging interactions

    Because you need to characterize the most challenging interactions

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  • The researcher’s guide to measuring binding affinity and why it matters

    The researcher’s guide to measuring binding affinity and why it matters

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  • Have a question about Monolith?

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  • Are you building an effective protein degrader? 4 questions to ask yourself to find out

    Are you building an effective protein degrader? 4 questions to ask yourself to find out

    Protein degraders are getting a lot of attention for being a new and promising modality to treat diseases such as cancer or Alzheimer’s disease. Rather than inhibiting the function of a protein,...

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  • Mischievous membrane proteins (and how to tame them)25:40

    Mischievous membrane proteins (and how to tame them)

    Are you struggling to tame your mischievous membrane proteins? Find out how NanoTemper can help you to characterize even the most challenging membrane protein samples. You will learn how Prometheus ca

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  • Are you building an effective protein degrader?

    Are you building an effective protein degrader?

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  • Optimize the structure of your next round of PROTAC compounds by analyzing ternary binding affinities using Monolith

    Optimize the structure of your next round of PROTAC compounds by analyzing ternary binding affinities using Monolith

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  • 6 protein degradation conferences in 2021 you can’t afford to miss

    6 protein degradation conferences in 2021 you can’t afford to miss

    Conferences in 2021 will gather scientists and experts eager to discuss new discoveries in the emerging field of targeted protein degradation (TPD). Many transcription factors, scaffold proteins,...

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  • Measure binding affinities for any type of interaction — examine a label-free or labeled target molecule at anytime

    Measure binding affinities for any type of interaction — examine a label-free or labeled target molecule at anytime

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  • Sweet and blind spots in E3 ligase ligand space revealed by a thermophoresis-based assay

    Sweet and blind spots in E3 ligase ligand space revealed by a thermophoresis-based assay

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  • Understanding the nuances of targeted protein degradation59:35

    Understanding the nuances of targeted protein degradation

    Bifunctional degrader molecules (also known as PROTACs) and molecular glues recruit proteins to E3 ubiquitin ligases. The formation of a ternary complex between PROTAC, ligase, and the protein of inte

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  • Thermophoretic analysis of ligand-specific conformational states of the inhibitory glycine receptor embedded in copolymer nanodiscs

    Thermophoretic analysis of ligand-specific conformational states of the inhibitory glycine receptor embedded in copolymer nanodiscs

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  • Can bioanalytical tools solve your neurodegenerative disease research challenges? 4 questions to ask yourself

    Can bioanalytical tools solve your neurodegenerative disease research challenges? 4 questions to ask yourself

    Despite extensive efforts, neurodegenerative diseases (ND) continue to feel like a pharmaceutical frontier. We have yet to see any effective drugs for conditions such as Alzheimer’s, Parkinson’s,...

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  • Have a question about Monolith?

    Contact Specialist
  • Detergent-free extraction of a functional low-expressing GPCR from a human cell line

    Detergent-free extraction of a functional low-expressing GPCR from a human cell line

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  • Scientists choose Monolith as their primary tool to measure binding interactions2:04

    Scientists choose Monolith as their primary tool to measure binding interactions

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  • Phospholipid membrane fluidity alters ligand binding activity of a G protein-coupled receptor by shifting the conformational equilibrium

    Phospholipid membrane fluidity alters ligand binding activity of a G protein-coupled receptor by shifting the conformational equilibrium

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  • Characterize the true nature of intrinsically disordered proteins without immobilizing them

    Characterize the true nature of intrinsically disordered proteins without immobilizing them

    If you study neurodegenerative diseases (ND), you already know they are one of the most challenging — and fascinating — types of diseases to study. With protein aggregation being a hallmark of ND,...

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  • Phosphorylation of human aquaporin 2 (AQP2) allosterically controls its interaction with the lysosomal trafficking protein LIP5

    Phosphorylation of human aquaporin 2 (AQP2) allosterically controls its interaction with the lysosomal trafficking protein LIP5

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  • When binding affinity matters.

    When binding affinity matters.

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  • Potent neutralization of clinical isolates of SARS-CoV-2 D614 and G614 variants by a monomeric, sub-nanomolar affinity nanobody

    Potent neutralization of clinical isolates of SARS-CoV-2 D614 and G614 variants by a monomeric, sub-nanomolar affinity nanobody

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