Monolith | Binding Affinity
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5:33
See the new Monolith — characterize your most challenging interactions
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Because you need to characterize the most challenging interactions
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The researcher’s guide to measuring binding affinity and why it matters
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Have a question about Monolith?
Contact Specialist -
Sweet and blind spots in E3 ligase ligand space revealed by a thermophoresis-based assay
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59:35
Understanding the nuances of targeted protein degradation
Bifunctional degrader molecules (also known as PROTACs) and molecular glues recruit proteins to E3 ubiquitin ligases. The formation of a ternary complex between PROTAC, ligase, and the protein of inte
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Thermophoretic analysis of ligand-specific conformational states of the inhibitory glycine receptor embedded in copolymer nanodiscs
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Detergent-free extraction of a functional low-expressing GPCR from a human cell line
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2:04
Scientists choose Monolith as their primary tool to measure binding interactions
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Phospholipid membrane fluidity alters ligand binding activity of a G protein-coupled receptor by shifting the conformational equilibrium
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Characterize the true nature of intrinsically disordered proteins without immobilizing them
If you study neurodegenerative diseases (ND), you already know they are one of the most challenging — and fascinating — types of diseases to study. With protein aggregation being a hallmark of ND,...
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Phosphorylation of human aquaporin 2 (AQP2) allosterically controls its interaction with the lysosomal trafficking protein LIP5
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When binding affinity matters.
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Structure of DtpA from E. coli in complex with Valganciclovir provides insights into drug binding of human PepT1
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Contact Specialist -
17:10
Trends and challenges in glycobiology: Biophysical tools to advance your molecular studies
The prominent role of glycans in biomedical research is exponentially raising as researchers discover how these sugars deeply affect protein structure and function.
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The peptide PROTAC modality: a novel strategy for targeted protein ubiquitination
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NanoTemper debuts the newly redesigned Monolith, offering higher-quality molecular interaction measurements for very challenging targets
PRESS RELEASE South San Francisco, CA. NanoTemper Technologies, well-known for creating biophysical tools that address challenging characterizations, today announced the new Monolith, redesigned...
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A cell-permeable peptide-based PROTAC against the oncoprotein CREPT proficiently inhibits pancreatic cancer
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Targeting the SARS-CoV‑2 RNA genome with small molecule binders and ribonuclease targeting chimera (RIBOTAC) degraders
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Accelerate your assay development using the enhanced Binding Check module in Monolith's MO.Control 2 software
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Targeted degradation of a hypoxia-associated non-coding RNA enhances the selectivity of a small molecule interacting with RNA
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