Monolith | Binding Affinity

  • See the new Monolith — characterize your most challenging interactions5:33

    See the new Monolith — characterize your most challenging interactions

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  • Because you need to characterize the most challenging interactions

    Because you need to characterize the most challenging interactions

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  • Molecular interactions - a simple framework: Energy, energy, energy27:20

    Molecular interactions - a simple framework: Energy, energy, energy

    Explore the complexities and drivers of molecular interactions with Dr. Tom Laue from the University of New Hampshire. He presented as a keynote speaker in the Protein Stability & Function: Can't have

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  • Ready to characterize your most challenging interactions?

    Discover tools to measure binding affinity

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  • Maximize stability & function of SARS-CoV-spike protein and ACE2 receptor using Monolith & Prometheus33:11

    Maximize stability & function of SARS-CoV-spike protein and ACE2 receptor using Monolith & Prometheus

    Dr. Leah Pandiscia and Dr. Daniel Turman review how to integrate the Prometheus Panta and Monolith instruments in a characterization workflow demonstration, showing how to maximize stability and funct

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  • The researcher’s guide to measuring binding affinity and why it matters

    The researcher’s guide to measuring binding affinity and why it matters

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  • NanoTemper’s Monolith wins top global design award: iF DESIGN AWARD 2021

    NanoTemper’s Monolith wins top global design award: iF DESIGN AWARD 2021

    NanoTemper’s newest Monolith instrument has been awarded the globally renowned iF DESIGN AWARD 2021. User-friendly design has always been a core focus in NanoTemper’s product development....

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  • Mischievous membrane proteins (and how to tame them)25:40

    Mischievous membrane proteins (and how to tame them)

    Are you struggling to tame your mischievous membrane proteins? Find out how NanoTemper can help you to characterize even the most challenging membrane protein samples. You will learn how Prometheus ca

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  • Targeted protein degradation promises to lead the way to effective drugs for challenging targets

    Targeted protein degradation promises to lead the way to effective drugs for challenging targets

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  • Are you building an effective protein degrader?

    Are you building an effective protein degrader?

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  • Optimize the structure of your next round of PROTAC compounds by analyzing ternary binding affinities using Monolith

    Optimize the structure of your next round of PROTAC compounds by analyzing ternary binding affinities using Monolith

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  • Quantifying the interaction of phosphite with ABC transporters: MicroScale Thermophoresis and a novel his-tag labeling approach

    Quantifying the interaction of phosphite with ABC transporters: MicroScale Thermophoresis and a novel his-tag labeling approach

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  • 4 ways to help you overcome the limitations of current methods in neurodegenerative disease research

    4 ways to help you overcome the limitations of current methods in neurodegenerative disease research

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  • Are you building an effective protein degrader? 4 questions to ask yourself to find out

    Are you building an effective protein degrader? 4 questions to ask yourself to find out

    Protein degraders are getting a lot of attention for being a new and promising modality to treat diseases such as cancer or Alzheimer’s disease. Rather than inhibiting the function of a protein,...

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  • Ready to characterize your most challenging interactions?

    Discover tools to measure binding affinity

    Learn more
  • Ddi1 is a ubiquitin-dependent protease

    Ddi1 is a ubiquitin-dependent protease

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  • Protein degraders show promising results in drug development pipelines. See what progress candidates have made.

    Protein degraders show promising results in drug development pipelines. See what progress candidates have made.

    There has been considerable and promising development in the field of targeted protein degradation (TPD) since the seminal discovery of PROTACs in 2001.1 The appeal of degraders like PROTACs lies...

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  • 6  protein degradation conferences in 2021 you can’t afford to miss

    6 protein degradation conferences in 2021 you can’t afford to miss

    Conferences in 2021 will gather scientists and experts eager to discuss new discoveries in the emerging field of targeted protein degradation (TPD). Many transcription factors, scaffold proteins,...

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  • Sweet and blind spots in E3 ligase ligand space revealed by a thermophoresis-based assay

    Sweet and blind spots in E3 ligase ligand space revealed by a thermophoresis-based assay

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  • Understanding the nuances of targeted protein degradation59:35

    Understanding the nuances of targeted protein degradation

    Bifunctional degrader molecules (also known as PROTACs) and molecular glues recruit proteins to E3 ubiquitin ligases. The formation of a ternary complex between PROTAC, ligase, and the protein of inte

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  • Measure binding affinities for any type of interaction — examine a label-free or labeled target molecule at anytime

    Measure binding affinities for any type of interaction — examine a label-free or labeled target molecule at anytime

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  • Let's catalyze - biophysical insights into enzymes1:32:25

    Let's catalyze - biophysical insights into enzymes

    Enzymes are nature's engine for many processes. Diving into the stability and function of enzymes will give us a better understanding of these processes. In this webinar, you will learn: -what biophy

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