Monolith | Binding Affinity

  • Virtual Monolith X Demo: Free-in-solution affinity measurements with minimal sample consumption​15:19

    Virtual Monolith X Demo: Free-in-solution affinity measurements with minimal sample consumption​

    The tool you choose to measure affinities should tackle a diverse range of targets and ligands that come your way — such as GPCRs, IDPs, or cancer-related proteins. And, you should get data that help

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  • Measure the strength of any interaction with versatile labeling options for Spectral Shift

    Measure the strength of any interaction with versatile labeling options for Spectral Shift

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  • The power of Monolith X for Characterizing GPCRs: Accelerating Binding Affinity Measurements20:31

    The power of Monolith X for Characterizing GPCRs: Accelerating Binding Affinity Measurements

    To understand signaling pathways, Spectral Shift technology allows for accurate bindings affinity measurements of membrane proteins like GPCRs in close to native conditions.

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  • Ready to characterize your most challenging interactions?

    Discover tools to measure binding affinity

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  • Three things we took away from attending Drug Discovery Chemistry in 2024

    Three things we took away from attending Drug Discovery Chemistry in 2024

    Drug Discovery Chemistry is an annual event that focuses solely on early drug discovery, where scientists from around the world gather to showcase their research and participate in thoughtful...

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  • NanoTemper announces Monolith X with breakthrough Spectral Shift technology, enabling affinity measurements where other methods fail

    NanoTemper announces Monolith X with breakthrough Spectral Shift technology, enabling affinity measurements where other methods fail

    NanoTemper Technologies introduced Monolith X, adding breakthrough Spectral Shift technology to their top-selling Monolith product line.

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  • Introducing Monolith X - the only way to get binding affinities in solution using very minimal sample2:20

    Introducing Monolith X - the only way to get binding affinities in solution using very minimal sample

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  • The only way to get binding affinities in solution using very minimal sample

    The only way to get binding affinities in solution using very minimal sample

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  • The researcher’s guide to measuring binding affinity and why it matters

    The researcher’s guide to measuring binding affinity and why it matters

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  • NanoTemper’s Monolith wins top global design award: Red Dot Award

    NanoTemper’s Monolith wins top global design award: Red Dot Award

    NanoTemper’s newest Monolith instrument has been awarded the Red Dot Award, an internationally recognized seal of excellence in design. Both bold aesthetics and user-friendly design have always...

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  • 10 terms to help you more easily understand targeted protein degradation

    10 terms to help you more easily understand targeted protein degradation

    If you’re new to the world of TPD or you’re trying to keep up with all developments in this fast-moving field, here are some terms and definitions that will help you.

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  • How to study molecular interactions of membrane proteins without compromising their native structure14:01

    How to study molecular interactions of membrane proteins without compromising their native structure

    The desire to use technology that allows you to study membrane proteins in close-to-native conditions is specifically important when it comes to interaction measurements. It’s always a question how mu

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  • Because you need to characterize the most challenging interactions

    Because you need to characterize the most challenging interactions

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  • Improve your protein degrader design with new ways to discover E3 ligase ligands35:47

    Improve your protein degrader design with new ways to discover E3 ligase ligands

    Targeted protein degradation using molecular glues or proteolysis-targeting chimeras (PROTACs) is an increasingly important therapeutic modality, especially for undruggable targets. Even with candidat

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  • A new spectral shift-based method to characterize molecular interactions

    A new spectral shift-based method to characterize molecular interactions

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  • Why so many companies are betting on PROTACs as a superior therapeutic modality

    Why so many companies are betting on PROTACs as a superior therapeutic modality

    One advantage of PROTACs is their unique mode of action — the induced proximity of an E3 ligase and the protein of interest (POI) triggers the ubiquitination and then degradation of the POI by the...

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  • Effect of different SARS-CoV-2 variants on COVID 19 assays and vaccines35:24

    Effect of different SARS-CoV-2 variants on COVID 19 assays and vaccines

    SARS-CoV-2, the causative agent of COVID-19, has an ssRNA genome of almost 30kb that encodes for a total of 26 proteins. Among the four structural viral protein, in particular the S protein stands out

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  • MST and TRIC technology to reliably study PROTAC binary and ternary binding in drug development

    MST and TRIC technology to reliably study PROTAC binary and ternary binding in drug development

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  • Molecular interactions - a simple framework: Energy, energy, energy27:20

    Molecular interactions - a simple framework: Energy, energy, energy

    Explore the complexities and drivers of molecular interactions with Dr. Tom Laue from the University of New Hampshire. He presented as a keynote speaker in the Protein Stability & Function: Can't have

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  • Maximize stability & function of SARS-CoV-spike protein and ACE2 receptor using Monolith & Prometheus33:11

    Maximize stability & function of SARS-CoV-spike protein and ACE2 receptor using Monolith & Prometheus

    Dr. Leah Pandiscia and Dr. Daniel Turman review how to integrate the Prometheus Panta and Monolith instruments in a characterization workflow demonstration, showing how to maximize stability and funct

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  • NanoTemper’s Monolith wins top global design award: iF DESIGN AWARD 2021

    NanoTemper’s Monolith wins top global design award: iF DESIGN AWARD 2021

    NanoTemper’s newest Monolith instrument has been awarded the globally renowned iF DESIGN AWARD 2021. User-friendly design has always been a core focus in NanoTemper’s product development....

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