Monolith | Binding Affinity

The peptide PROTAC modality: a novel strategy for targeted protein ubiquitination

Characterize the true nature of intrinsically disordered proteins without immobilizing them

If you study neurodegenerative diseases (ND), you already know they are one of the most challenging — and fascinating — types of diseases to study. With protein aggregation being a hallmark of ND,...

A cell-permeable peptide-based PROTAC against the oncoprotein CREPT proficiently inhibits pancreatic cancer

Targeting the SARS-CoV‑2 RNA genome with small molecule binders and ribonuclease targeting chimera (RIBOTAC) degraders

NanoTemper debuts the newly redesigned Monolith, offering higher-quality molecular interaction measurements for very challenging targets

PRESS RELEASE South San Francisco, CA. NanoTemper Technologies, well-known for creating biophysical tools that address challenging characterizations, today announced the new Monolith, redesigned...

Targeted degradation of a hypoxia-associated non-coding RNA enhances the selectivity of a small molecule interacting with RNA

The NanoTemper Story – Chapter 2: The Monolith

It’s late at night in Munich, Germany sometime in the late 2000’s. A man huddles in a dimly lit basement, painting. He paints at night after a complaint from the professors upstairs about the...

High-resolution structure and biophysical characterization of the nucleocapsid phosphoprotein dimerization domain from Coronavirus 2

Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2

Isoform-Selective ATAD2 chemical probe with novel chemical structure and unusual mode of action

4 studies highlight the impact of biophysical tools in plant science research

Plant research paves the way for important advances in agriculture, ecology, and medicine. As an example, discoveries into plant pathogens and plant stress response lead to many incremental...