Monolith | Binding Affinity

  • See the new Monolith — characterize your most challenging interactions5:33

    See the new Monolith — characterize your most challenging interactions

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  • Because you need to characterize the most challenging interactions

    Because you need to characterize the most challenging interactions

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  • The researcher’s guide to measuring binding affinity and why it matters

    The researcher’s guide to measuring binding affinity and why it matters

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  • Have a question about Monolith?

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  • Sweet and blind spots in E3 ligase ligand space revealed by a thermophoresis-based assay

    Sweet and blind spots in E3 ligase ligand space revealed by a thermophoresis-based assay

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  • Understanding the nuances of targeted protein degradation59:35

    Understanding the nuances of targeted protein degradation

    Bifunctional degrader molecules (also known as PROTACs) and molecular glues recruit proteins to E3 ubiquitin ligases. The formation of a ternary complex between PROTAC, ligase, and the protein of inte

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  • Thermophoretic analysis of ligand-specific conformational states of the inhibitory glycine receptor embedded in copolymer nanodiscs

    Thermophoretic analysis of ligand-specific conformational states of the inhibitory glycine receptor embedded in copolymer nanodiscs

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  • Detergent-free extraction of a functional low-expressing GPCR from a human cell line

    Detergent-free extraction of a functional low-expressing GPCR from a human cell line

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  • Scientists choose Monolith as their primary tool to measure binding interactions2:04

    Scientists choose Monolith as their primary tool to measure binding interactions

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  • Phospholipid membrane fluidity alters ligand binding activity of a G protein-coupled receptor by shifting the conformational equilibrium

    Phospholipid membrane fluidity alters ligand binding activity of a G protein-coupled receptor by shifting the conformational equilibrium

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  • Characterize the true nature of intrinsically disordered proteins without immobilizing them

    Characterize the true nature of intrinsically disordered proteins without immobilizing them

    If you study neurodegenerative diseases (ND), you already know they are one of the most challenging — and fascinating — types of diseases to study. With protein aggregation being a hallmark of ND,...

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  • Phosphorylation of human aquaporin 2 (AQP2) allosterically controls its interaction with the lysosomal trafficking protein LIP5

    Phosphorylation of human aquaporin 2 (AQP2) allosterically controls its interaction with the lysosomal trafficking protein LIP5

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  • When binding affinity matters.

    When binding affinity matters.

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  • Structure of DtpA from E. coli in complex with Valganciclovir provides insights into drug binding of human PepT1

    Structure of DtpA from E. coli in complex with Valganciclovir provides insights into drug binding of human PepT1

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  • Have a question about Monolith?

    Contact Specialist
  • Trends and challenges in glycobiology: Biophysical tools to advance your molecular studies17:10

    Trends and challenges in glycobiology: Biophysical tools to advance your molecular studies

    The prominent role of glycans in biomedical research is exponentially raising as researchers discover how these sugars deeply affect protein structure and function.

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  • The peptide PROTAC modality: a novel strategy for targeted protein ubiquitination

    The peptide PROTAC modality: a novel strategy for targeted protein ubiquitination

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  • NanoTemper debuts the newly redesigned Monolith, offering higher-quality molecular interaction measurements for very challenging targets

    NanoTemper debuts the newly redesigned Monolith, offering higher-quality molecular interaction measurements for very challenging targets

    PRESS RELEASE South San Francisco, CA. NanoTemper Technologies, well-known for creating biophysical tools that address challenging characterizations, today announced the new Monolith, redesigned...

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  • A cell-permeable peptide-based PROTAC against the oncoprotein CREPT proficiently inhibits pancreatic cancer

    A cell-permeable peptide-based PROTAC against the oncoprotein CREPT proficiently inhibits pancreatic cancer

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  • Targeting the SARS-CoV‑2 RNA genome with small molecule binders and ribonuclease targeting chimera (RIBOTAC) degraders

    Targeting the SARS-CoV‑2 RNA genome with small molecule binders and ribonuclease targeting chimera (RIBOTAC) degraders

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  • Accelerate your assay development using the enhanced Binding Check module in Monolith's MO.Control 2 software

    Accelerate your assay development using the enhanced Binding Check module in Monolith's MO.Control 2 software

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  • Targeted degradation of a hypoxia-associated non-coding RNA enhances the selectivity of a small molecule interacting with RNA

    Targeted degradation of a hypoxia-associated non-coding RNA enhances the selectivity of a small molecule interacting with RNA

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