Monolith | Binding Affinity

  • Scientists choose Monolith as their primary tool to measure binding interactions2:04

    Scientists choose Monolith as their primary tool to measure binding interactions

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  • When binding affinity matters.

    When binding affinity matters.

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  • The importance of molecular interactions and stability in Gene Therapy46:44

    The importance of molecular interactions and stability in Gene Therapy

    New advances in gene therapy have triggered a resurgence of interest in the field. Though gene therapy offers exciting potential for the treatment of both monogenic disorders as well as more genetical

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  • Have a question about Monolith?

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  • The researcher’s guide to measuring binding affinity and why it matters

    The researcher’s guide to measuring binding affinity and why it matters

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  • What these 3 publications uncovered about coronavirus protein structures using MST

    What these 3 publications uncovered about coronavirus protein structures using MST

    Coronaviruses (CoV) have been responsible for multiple outbreaks this century. The 2020 COVID-19 pandemic — caused by the novel SARS-CoV-2 coronavirus — has led to a global health, social, and...

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  • Site-specific covalent labeling of SNAP-tagged proteins for the measurement of binding affinities

    Site-specific covalent labeling of SNAP-tagged proteins for the measurement of binding affinities

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  • Solutions for Plant Science14:45

    Solutions for Plant Science

    As the population grows, our environment is changing and our natural resources are being depleted. That’s why research on plant production, temperature and pathogen resistance, environmental stress, p

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  • Antibody-targeted chromatin enables effective intracellular delivery and functionality of CRISPR/Cas9 expression plasmids

    Antibody-targeted chromatin enables effective intracellular delivery and functionality of CRISPR/Cas9 expression plasmids

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  • Did you say, “membrane proteins”? Challenge accepted!4:09

    Did you say, “membrane proteins”? Challenge accepted!

    Working with difficult targets like GPCRs and other membrane proteins? Because they live in the cell membrane, are hydrophobic and insoluble, have low expression levels, and require particular deter

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  • Measure molecular interactions in purification-free systems8:04

    Measure molecular interactions in purification-free systems

    In this short video, you will learn: -How labs are able to measure binding affinity in complex systems -Why it's important to look at binding affinity in complex bioliquids or in vivo -How to study mo

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  • Advance your understanding of neurodegenerative diseases

    Advance your understanding of neurodegenerative diseases

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  • What binding affinity and binding kinetics tell you about protein-ligand interactions

    What binding affinity and binding kinetics tell you about protein-ligand interactions

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  • Francisella novicida Cas9 interrogates genomic DNA with very high specificity and can be used for mammalian genome editing

    Francisella novicida Cas9 interrogates genomic DNA with very high specificity and can be used for mammalian genome editing

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  • Have a question about Monolith?

    Contact Specialist
  • Easily characterize the molecular mechanisms of neurodegenerative diseases

    Easily characterize the molecular mechanisms of neurodegenerative diseases

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  • Molecular tools to study viral infectious diseases13:27

    Molecular tools to study viral infectious diseases

    Pandemics have affected human society throughout history, but with the current pandemic happening today, realization is quickly setting in just how much viral infectious diseases impact everyday life.

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  • Spatial screening of hemagglutinin on Influenza A Virus particles: Sialyl-LacNAc displays on DNA and PEG scaffolds reveal requirements

    Spatial screening of hemagglutinin on Influenza A Virus particles: Sialyl-LacNAc displays on DNA and PEG scaffolds reveal requirements

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  • Protein labeling – improved quantitation of biomolecular interactions by MST using the His-Tag labeling kit RED-tris-NTA 2nd generation

    Protein labeling – improved quantitation of biomolecular interactions by MST using the His-Tag labeling kit RED-tris-NTA 2nd generation

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  • Cyrill Brunner gets Explorer Award for innovative approach to advance drug discovery research using computer modeling

    Cyrill Brunner gets Explorer Award for innovative approach to advance drug discovery research using computer modeling

    Meet Cyrill Brunner, Senior PhD candidate at ETH in Zurich, Switzerland (preparing to defend his thesis as we go to press) and one of the 2019 Explorer award recipients. This award is given to...

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  • Neurodegenerative Diseases: Studying protein aggregation using NanoTemper instruments16:04

    Neurodegenerative Diseases: Studying protein aggregation using NanoTemper instruments

    Neurodegenerative diseases like Alzheimer’s or Parkinson’s Disease affect millions of people worldwide. Although current treatments may help relieve some of the physical or mental symptoms, there is s

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  • Humanized Selective CD19CAR-T Cells Treatment Shows Efficacy in B-ALL Patients Who Relapsed after Receiving Murine-Based CD19CAR-T Therapies

    Humanized Selective CD19CAR-T Cells Treatment Shows Efficacy in B-ALL Patients Who Relapsed after Receiving Murine-Based CD19CAR-T Therapies

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