Monolith | Binding Affinity
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5:33WatchSee the new Monolith — characterize your most challenging interactions
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Because you need to characterize the most challenging interactions
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The researcher’s guide to measuring binding affinity and why it matters
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ReadNanoTemper’s Monolith wins top global design award: Red Dot Award
NanoTemper’s newest Monolith instrument has been awarded the Red Dot Award, an internationally recognized seal of excellence in design. Both bold aesthetics and user-friendly design have always...
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14:01WatchHow to study molecular interactions of membrane proteins without compromising their native structure
The desire to use technology that allows you to study membrane proteins in close-to-native conditions is specifically important when it comes to interaction measurements. It’s always a question how mu
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35:47WatchImprove your protein degrader design with new ways to discover E3 ligase ligands
Targeted protein degradation using molecular glues or proteolysis-targeting chimeras (PROTACs) is an increasingly important therapeutic modality, especially for undruggable targets. Even with candidat
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ReadWhy so many companies are betting on PROTACs as a superior therapeutic modality
With PROTACs currently in the clinical and preclinical stages, they are making exciting progress towards successfully treating patients who have been waiting for effective therapies for certain...
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ReadMST and TRIC technology to reliably study PROTAC binary and ternary binding in drug development
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27:20WatchMolecular interactions - a simple framework: Energy, energy, energy
Explore the complexities and drivers of molecular interactions with Dr. Tom Laue from the University of New Hampshire. He presented as a keynote speaker in the Protein Stability & Function: Can't have
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33:11WatchMaximize stability & function of SARS-CoV-spike protein and ACE2 receptor using Monolith & Prometheus
Dr. Leah Pandiscia and Dr. Daniel Turman review how to integrate the Prometheus Panta and Monolith instruments in a characterization workflow demonstration, showing how to maximize stability and funct
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ReadNanoTemper’s Monolith wins top global design award: iF DESIGN AWARD 2021
NanoTemper’s newest Monolith instrument has been awarded the globally renowned iF DESIGN AWARD 2021. User-friendly design has always been a core focus in NanoTemper’s product development....
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25:40WatchMischievous membrane proteins (and how to tame them)
Are you struggling to tame your mischievous membrane proteins? Find out how NanoTemper can help you to characterize even the most challenging membrane protein samples. You will learn how Prometheus ca
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ReadTargeted protein degradation promises to lead the way to effective drugs for challenging targets
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Discover tools to measure binding affinity -
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Are you building an effective protein degrader?
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Optimize the structure of your next round of PROTAC compounds by analyzing ternary binding affinities using Monolith
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ReadQuantifying the interaction of phosphite with ABC transporters: MicroScale Thermophoresis and a novel his-tag labeling approach
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Read4 ways to help you overcome the limitations of current methods in neurodegenerative disease research
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ReadAre you building an effective protein degrader? 4 questions to ask yourself to find out
Protein degraders are getting a lot of attention for being a new and promising modality to treat diseases such as cancer or Alzheimer’s disease. Rather than inhibiting the function of a protein,...
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ReadDdi1 is a ubiquitin-dependent protease
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ReadProtein degraders show promising results in drug development pipelines. See progress candidates have made.
There has been considerable and promising development in the field of targeted protein degradation (TPD) since the seminal discovery of PROTACs in 2001.1 The appeal of degraders like PROTACs lies...
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