Monolith | Binding Affinity
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43:09WatchCube x NanoTemper Webinar Series – Episode 1: Optimize membrane protein characterization with NativeMP and Multiplexing Optical Methods
Learn about technologies and instruments that maintain membrane protein stability and allow structural abd affinity screening studies in their natural lipid environment.
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ReadAchieve Highly Sensitive and Precise Binding Affinity Measurements Without Disrupting Protein Conformation
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15:19WatchVirtual Monolith X Demo: Free-in-solution affinity measurements with minimal sample consumption
The tool you choose to measure affinities should tackle a diverse range of targets and ligands that come your way — such as GPCRs, IDPs, or cancer-related proteins. And, you should get data that help
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Discover tools to measure binding affinity -
ReadMeasure the strength of any interaction with versatile labeling options for Spectral Shift
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20:31WatchThe power of Monolith X for Characterizing GPCRs: Accelerating Binding Affinity Measurements
To understand signaling pathways, Spectral Shift technology allows for accurate bindings affinity measurements of membrane proteins like GPCRs in close to native conditions.
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ReadThree things we took away from attending Drug Discovery Chemistry in 2024
Drug Discovery Chemistry is an annual event that focuses solely on early drug discovery, where scientists from around the world gather to showcase their research and participate in thoughtful...
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ReadNanoTemper announces Monolith X with breakthrough Spectral Shift technology, enabling affinity measurements where other methods fail
NanoTemper Technologies introduced Monolith X, adding breakthrough Spectral Shift technology to their top-selling Monolith product line.
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2:20WatchIntroducing Monolith X - the only way to get binding affinities in solution using very minimal sample
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The only way to get binding affinities in solution using very minimal sample
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The researcher’s guide to measuring binding affinity and why it matters
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ReadNanoTemper’s Monolith wins top global design award: Red Dot Award
NanoTemper’s newest Monolith instrument has been awarded the Red Dot Award, an internationally recognized seal of excellence in design. Both bold aesthetics and user-friendly design have always...
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Read10 terms to help you more easily understand targeted protein degradation
If you’re new to the world of TPD or you’re trying to keep up with all developments in this fast-moving field, here are some terms and definitions that will help you.
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14:01WatchHow to study molecular interactions of membrane proteins without compromising their native structure
The desire to use technology that allows you to study membrane proteins in close-to-native conditions is specifically important when it comes to interaction measurements. It’s always a question how mu
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Because you need to characterize the most challenging interactions
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35:47WatchImprove your protein degrader design with new ways to discover E3 ligase ligands
Targeted protein degradation using molecular glues or proteolysis-targeting chimeras (PROTACs) is an increasingly important therapeutic modality, especially for undruggable targets. Even with candidat
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ReadA new spectral shift-based method to characterize molecular interactions
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ReadWhy so many companies are betting on PROTACs as a superior therapeutic modality
One advantage of PROTACs is their unique mode of action — the induced proximity of an E3 ligase and the protein of interest (POI) triggers the ubiquitination and then degradation of the POI by the...
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35:24WatchEffect of different SARS-CoV-2 variants on COVID 19 assays and vaccines
SARS-CoV-2, the causative agent of COVID-19, has an ssRNA genome of almost 30kb that encodes for a total of 26 proteins. Among the four structural viral protein, in particular the S protein stands out
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ReadMST and TRIC technology to reliably study PROTAC binary and ternary binding in drug development
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27:20WatchMolecular interactions - a simple framework: Energy, energy, energy
Explore the complexities and drivers of molecular interactions with Dr. Tom Laue from the University of New Hampshire. He presented as a keynote speaker in the Protein Stability & Function: Can't have
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