Membrane proteins play a pivotal role in cellular signaling and communication, making them prime targets in modern drug discovery. Yet, their intrinsic complexity and instability outside of their native membrane environments present formidable challenges for structural and functional analysis. Traditional detergent-based methods often compromise protein integrity, limiting accurate biophysical characterization.
Watch this webinar to learn:
• How detergent-free synthetic copolymers, as used in Cube Biotech’s NativeMP™ Technology, help maintain membrane protein stability in environments that mimic native membranes.
• How the Monolith X instrument from NanoTemper Technologies applies Spectral Shift and TRIC methods to measure biomolecular interactions with high sensitivity and without labeling.
• How the integration of these technologies enables accurate binding affinity analysis while preserving membrane protein structure and function.
• How these approaches address common challenges in membrane protein research and support more reliable data generation for drug interaction studies.
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