Stability of biopharmaceuticals is a complex matrix of parameters that plays a crucial role through the entire product life-cycle. Through case studies, we discuss how Prometheus provides clarity by delivering precise and reliable stability measurements, outperforming existing tools, to inform critical decisions throughout the product life-cycle.
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![Fragment Screening: Save time and sample with Spectral Shift technology](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fres.cloudinary.com%2Fuf-553493%2Fimage%2Fupload%2Fv1718223975%2FSlide3_khawi0.png&size=1&version=1720797301&sig=c43bdc969ec154b0c200b7dafb532a73&default=hubs%2Ftilebg-videos.jpg)
Many methods used in fragment-based drug discovery pose real challenges — SPR often struggles to detect true hits due to fragments’ small mass, DSF can have high rates of false positives, and NMR equi
![De-risk your antibody characterization workflows with high-quality, multi-parameter stability data from Prometheus Panta](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fres.cloudinary.com%2Fuf-553493%2Fimage%2Fupload%2Fv1716468987%2FUberflip_Thumbnail_ert2xy.png&size=1&version=1716469212&sig=df3c439708b93ebbd43ef4c1ecc3ce7e&default=hubs%2Ftilebg-videos.jpg)
Get developability profiles for monoclonal antibodies with stability data from Prometheus Panta to inform on rational design and selection of therapeutic constructs that will succeed in the clinic.
![Biologics Formulation: Select optimal buffer conditions with multi-parameter stability characterization from Prometheus Panta](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fcontent.cdntwrk.com%2Ffiles%2FaHViPTg2NTQ5JmNtZD1pdGVtZWRpdG9yaW1hZ2UmZmlsZW5hbWU9aXRlbWVkaXRvcmltYWdlXzY2MmZkZmJjOTJmZjYucG5nJnZlcnNpb249MDAwMCZzaWc9OGYxOGQ0ODg5ZTVhYjJkNzVlYjI1MmU5MDI0OWNjOGY%25253D&size=1&version=1714413510&sig=e7113872c465e6d045c346261714b0f9&default=hubs%2Ftilebg-videos.jpg)
Learn how to identify optimal buffer conditions during pre-formulation, with multi-parameter stability characterization from Prometheus Panta, a tool to collect thermal and colloidal data while saving
![Assess the impact of bioconjugation with multi-parameter stability characterization](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fcontent.cdntwrk.com%2Ffiles%2FaHViPTg2NTQ5JmNtZD1pdGVtZWRpdG9yaW1hZ2UmZmlsZW5hbWU9aXRlbWVkaXRvcmltYWdlXzY1ZjliNDgxNmQ1NzQucG5nJnZlcnNpb249MDAwMCZzaWc9MWNhOTdkMDc3OWNkYjJmZjdiZjAwMjg5OWM3OGRjNjY%25253D&size=1&version=1714412448&sig=330d90a750b1cef76374a164ef6a281c&default=hubs%2Ftilebg-videos.jpg)
Characterize the developability of antibody-drug conjugates: Multi-parameter stability assessment with Prometheus Panta makes it possible to examine multiple aspects of ADC stability in parallel.
![How stability prediction experiments give you confidence in your ADCs](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fcontent.cdntwrk.com%2Ffiles%2FaHViPTg2NTQ5JmNtZD1pdGVtZWRpdG9yaW1hZ2UmZmlsZW5hbWU9aXRlbWVkaXRvcmltYWdlXzY1ZTZmZDYzNDU0MTgucG5nJnZlcnNpb249MDAwMCZzaWc9MGM1ZGRmN2ZmYzdjZmUyYTViODI3ZmE1OWQyYTM2MTY%25253D&size=1&version=1715958612&sig=3b6a68bd993d755ae01d447a96466cb2&default=hubs%2Ftilebg-videos.jpg)
For antibody-drug conjugate (ADC) development, scientists rely on stability experiments using fluorescence and light scattering techniques to predict the conjugated molecule's behavior.
![The power of Monolith X for Characterizing GPCRs: Accelerating Binding Affinity Measurements](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fcontent.cdntwrk.com%2Ffiles%2FaHViPTg2NTQ5JmNtZD1pdGVtZWRpdG9yaW1hZ2UmZmlsZW5hbWU9aXRlbWVkaXRvcmltYWdlXzY1ZTA4YjAzMDljOTYucG5nJnZlcnNpb249MDAwMCZzaWc9OTkxNGVhMzIxZTAyMjk5YmY4YzQ1Yjc3N2E0YzBmZTM%25253D&size=1&version=1715959201&sig=281cc151c7988000618f90ac9d4511df&default=hubs%2Ftilebg-videos.jpg)
To understand signaling pathways, Spectral Shift technology allows for accurate bindings affinity measurements of membrane proteins like GPCRs in close to native conditions.
![The use of Spectral Shift in identifying Microcycle® hits for challenging therapeutic targets](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fcontent.cdntwrk.com%2Ffiles%2FaHViPTg2NTQ5JmNtZD1pdGVtZWRpdG9yaW1hZ2UmZmlsZW5hbWU9aXRlbWVkaXRvcmltYWdlXzY1N2NhOGVhMTM1YjQucG5nJnZlcnNpb249MDAwMCZzaWc9ZWVkYmE4MjA0MzRiMDYwYzcxMDY3ZjZkMWU5OGRhMGQ%25253D&size=1&version=1715959214&sig=9493ba6d5943db02e735cc6db934348f&default=hubs%2Ftilebg-videos.jpg)
Transcription factors have traditionally been considered challenging therapeutic targets. Their intrinsic disorder and lack of small molecule binding pockets make them intractable to small molecule ap
![Applying Spectral Shift technology to study IDPs: Direct binding and displacement assays of MYC:MAX inhibitors](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fcontent.cdntwrk.com%2Ffiles%2FaHViPTg2NTQ5JmNtZD1pdGVtZWRpdG9yaW1hZ2UmZmlsZW5hbWU9aXRlbWVkaXRvcmltYWdlXzY1N2NhNjZiNjY2MDAucG5nJnZlcnNpb249MDAwMCZzaWc9MmRlMzU5NWEzOTUzYTcyOThjYjdkMTVkNmVjOWI3OGY%25253D&size=1&version=1715959235&sig=02bd49787d6f2b1c8a7ac5811cd188fd&default=hubs%2Ftilebg-videos.jpg)
MYC is an important therapeutic target that associates with MAX to regulate gene transcription. Its lack of binding pockets and the presence of disordered regions make it a difficult protein to study
![Conversation: How Aaron Frimel from Thermo Fisher Scientific approaches biologics formulation](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fcontent.cdntwrk.com%2Ffiles%2FaHViPTg2NTQ5JmNtZD1pdGVtZWRpdG9yaW1hZ2UmZmlsZW5hbWU9aXRlbWVkaXRvcmltYWdlXzY1Njg5NWUxNmE0MTUucG5nJnZlcnNpb249MDAwMCZzaWc9YmI5OTZkNmY1YWQ2M2U2Y2NmOWJlNGM2OTYzOGUyZGU%25253D&size=1&version=1701353040&sig=760f4216303ee3c862160680eae99ae2&default=hubs%2Ftilebg-videos.jpg)
Join this conversation to gain insight into how the Analytical and Formulation Sciences team at Thermo Fisher Scientific approaches stability assessment of biologic, and how the Prometheus Panta helps
![How to mitigate risk during ADC development with multi-parameter stability characterization](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fcontent.cdntwrk.com%2Ffiles%2FaHViPTg2NTQ5JmNtZD1pdGVtZWRpdG9yaW1hZ2UmZmlsZW5hbWU9aXRlbWVkaXRvcmltYWdlXzY1MzdjOGYzOWU1YmMucG5nJnZlcnNpb249MDAwMCZzaWc9ZDRlMjY4YzBhYTFkZDc2ZmY0MGUzMTYwMjZkNDE5ZmU%25253D&size=1&version=1709636476&sig=e160a5a2f2da8b58f82159f13e5020e5&default=hubs%2Ftilebg-videos.jpg)
To assess the developability properties of antibody-drug conjugates (ADCs) learn about multi-parameter characterization of thermal and colloidal stability with Prometheus Panta using nanoDSF and DLS
![nanoDSF for biologics: How to interpret thermal unfolding profiles for your different applications](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fcontent.cdntwrk.com%2Ffiles%2FaHViPTg2NTQ5JmNtZD1pdGVtZWRpdG9yaW1hZ2UmZmlsZW5hbWU9aXRlbWVkaXRvcmltYWdlXzY1MTU2Mjk4OGFkYTYucG5nJnZlcnNpb249MDAwMCZzaWc9YWMyMDUwYmEwNzA4ZmJjMTA2OTdjZGJhZGE0NDcxZTA%25253D&size=1&version=1715958626&sig=46a94f2734cb38e896b6c7d7ba057c8e&default=hubs%2Ftilebg-videos.jpg)
Thermal stability screening is a common approach used to study the developability of a wide range of protein-based therapeutics. Among the different technologies available to perform thermal stability
![Thermal stability measurements for biologics developability profiling](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fcontent.cdntwrk.com%2Ffiles%2FaHViPTg2NTQ5JmNtZD1pdGVtZWRpdG9yaW1hZ2UmZmlsZW5hbWU9aXRlbWVkaXRvcmltYWdlXzY1MDBiNzI5MDM5MjYucG5nJnZlcnNpb249MDAwMCZzaWc9ZWNlOTAzMWY4MGQ0OGI3MzM0NTQ3OTQwZTBkMDU2Mjg%25253D&size=1&version=1709636630&sig=d86c8fb5a16acca0f7210ecb0b30a3a1&default=hubs%2Ftilebg-videos.jpg)
Learn about four methods for thermal stability measurements: DSC, CD, DSF and nanoDSF. You'll review their pros and cons, what they data tell you and why it's important for biologics developability.
![Selective degradation of cancer target WDR5 — Evaluation of PROTACs binary and ternary affinities with Spectral Shift](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fcontent.cdntwrk.com%2Ffiles%2FaHViPTg2NTQ5JmNtZD1pdGVtZWRpdG9yaW1hZ2UmZmlsZW5hbWU9aXRlbWVkaXRvcmltYWdlXzY0ZjdiZDhkYjE5YWQucG5nJnZlcnNpb249MDAwMCZzaWc9YmVhMDk0ZGE4YWZjMThkYWZiOWQyMjlkNzNkZjM2OGU%25253D&size=1&version=1715959244&sig=93ee72366352234afc01da5c50ffdc44&default=hubs%2Ftilebg-videos.jpg)
Chances are your company’s research and development pipeline includes several PROTAC candidates — placing you with many others in the race to bring successful and efficient protein degraders to the cl
![Explore Prometheus Panta – Frequently asked questions about stability profiling experiments](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fcontent.cdntwrk.com%2Ffiles%2FaHViPTg2NTQ5JmNtZD1pdGVtZWRpdG9yaW1hZ2UmZmlsZW5hbWU9aXRlbWVkaXRvcmltYWdlXzY0ZTcxYjljN2VkYTUucG5nJnZlcnNpb249MDAwMCZzaWc9NTMxMzllMjYwNDQxY2IyZWQxZjEwZGEyOTNkOGU5MTE%25253D&size=1&version=1692867545&sig=ba087357d9120c46a5c3b32022eefb8d&default=hubs%2Ftilebg-videos.jpg)
In this video, Nathan Wallace, Application Specialist at NanoTemper, addresses common questions about experimental design for developability profiling and the operation of Prometheus Panta.
![Explore Prometheus Panta – Biologics developability assessment with four integrated technologies](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fcontent.cdntwrk.com%2Ffiles%2FaHViPTg2NTQ5JmNtZD1pdGVtZWRpdG9yaW1hZ2UmZmlsZW5hbWU9aXRlbWVkaXRvcmltYWdlXzY0ZTMyN2JjMzA1MGEucG5nJnZlcnNpb249MDAwMCZzaWc9ZmE3MzU4N2RlMGQ1MDNiNWEzNjIzMDUzZjdkNGRjNTE%25253D&size=1&version=1692867213&sig=9a7465d3b3db60eb1f6f763bfc2ab00d&default=hubs%2Ftilebg-videos.jpg)
Developability assessment is a critical part of the evaluation and selection of candidates for further optimization and development for biologics researchers. This work entails collecting, ranking, an
![How to keep your degrader pipeline moving forward with Dianthus](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fcontent.cdntwrk.com%2Ffiles%2FaHViPTg2NTQ5JmNtZD1pdGVtZWRpdG9yaW1hZ2UmZmlsZW5hbWU9aXRlbWVkaXRvcmltYWdlXzY0YzA0ZDY0NTg4YmUucG5nJnZlcnNpb249MDAwMCZzaWc9ODlmMDk1M2Y5NThjNWFhYjgyOGUwYjU5ZTk4MjZkZmY%25253D&size=1&version=1715959256&sig=7c1309144d674324bea23f7098ada74b&default=hubs%2Ftilebg-videos.jpg)
The development of your protein degrader is a multi-step and complex process usually packed with challenges that if left unsolved will delay the progress of your project. What if you could overcome co
![How biologics teams approach developability screening of their candidates with combinatorial stability characterization](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fcontent.cdntwrk.com%2Ffiles%2FaHViPTg2NTQ5JmNtZD1pdGVtZWRpdG9yaW1hZ2UmZmlsZW5hbWU9aXRlbWVkaXRvcmltYWdlXzY0YWRhNjYwMDk3ODUucG5nJnZlcnNpb249MDAwMCZzaWc9NDM5YmQ0Y2Q2MjlhNWMzOGUxN2NjYmY5YTMwOWViNDQ%25253D&size=1&version=1689166070&sig=2a89e6a7f19d52be92f98d11fae2b0a5&default=hubs%2Ftilebg-videos.jpg)
Full developability profiles de-risk the selection process for biologics candidates during early development workflows. There are many critical quality attributes to evaluate when it comes to developa
![How to use light scattering techniques to predict your biologic's self-association behavior at high concentrations](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fcontent.cdntwrk.com%2Ffiles%2FaHViPTg2NTQ5JmNtZD1pdGVtZWRpdG9yaW1hZ2UmZmlsZW5hbWU9aXRlbWVkaXRvcmltYWdlXzY0N2EzODA3ZTZhZmEucG5nJnZlcnNpb249MDAwMCZzaWc9YjMzY2Y4ZTNlNGViNGRhMjdlN2VlOGZjNmNiZjUwNjE%25253D&size=1&version=1713519298&sig=94dbc9515e796bcc66456f9d5f988d7d&default=hubs%2Ftilebg-videos.jpg)
Developability work requires the assessment of multiple critical quality attributes (CQAs) of your biologics. Many of these CQAs are measured or monitored using low-volume, low-concentration samples.
![How biologics teams use Dynamic Light Scattering to identify leading candidates](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fcontent.cdntwrk.com%2Ffiles%2FaHViPTg2NTQ5JmNtZD1pdGVtZWRpdG9yaW1hZ2UmZmlsZW5hbWU9aXRlbWVkaXRvcmltYWdlXzY0M2VlYjk1MTcyZTkucG5nJnZlcnNpb249MDAwMCZzaWc9OGFlZGIzNmNhMjhjYzU5NGIxMmMyMTYyYzFiNWQwNGE%25253D&size=1&version=1715958303&sig=2e993d4f16f05b3e69c1e0778eaa3093&default=hubs%2Ftilebg-videos.jpg)
Watch this 15 min video to learn how groups in early biologics development and formulation use Dynamic Light Scattering (DLS) to make informed decisions that de-risk downstream biologics development.
![Overcome bottlenecks in viral vector manufacturing](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fcontent.cdntwrk.com%2Ffiles%2FaHViPTg2NTQ5JmNtZD1pdGVtZWRpdG9yaW1hZ2UmZmlsZW5hbWU9aXRlbWVkaXRvcmltYWdlXzYxOTIzYzkzZTFjYmIuanBnJnZlcnNpb249MDAwMCZzaWc9NTEwYWJhYjViYmRmNjVhOWUwYjk3NzY5Y2I0YTRhZTI%25253D&size=1&version=1715958537&sig=7333fc9d8a85b8437071c031e939a909&default=hubs%2Ftilebg-videos.jpg)
The success of your gene therapy vectors is dependent on optimal formulation conditions. Finding a buffer that provides better long-term stability for AAVs is a crucial step in the process of developi