How to use light scattering techniques to predict your biologic's self-association behavior at high concentrations

June 1, 2023

Developability work requires the assessment of multiple critical quality attributes (CQAs) of your biologics. Many of these CQAs are measured or monitored using low-volume, low-concentration samples. However, once biologic therapeutics reach the clinic, they are administered at high concentrations, which may result in different stability characteristics of the drug.

In order to predict whether a protein-based therapeutic will remain stable at these high concentrations, researchers turn to dedicated experiments using light scattering techniques. These experiments help predict whether a biologic will become viscous or aggregated at high concentration.

Watch this event to get an overview of self-association prediction strategies. In this event, you will learn:

  • Why it is so critical to assess self-association propensity
  • How to set up and design experiments for self-association, and what parameters are measured with light scattering techniques
  • How a group at Merck KGaA developed an alternative methodology for predicting self-association


And if you’re interested in integrating self-association propensity measurements into your developability workflows, learn how Prometheus Panta provides information on your biologics.

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