A big hurdle in small molecule drug discovery screening is confidently identifying positive hits in a timely manner. Screening fragment libraries is challenging with current methodologies that are either time-consuming or lack detection sensitivity. Dianthus NT.23PicoDuo utilizes a biophysical detection method for fast, precise and confident hit identification, target validation and lead optimization. An example of single-dose and affinity screening against histone methylase G9a, known to be associated with cancer onset, will be discussed.
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