Sign up to receive
the latest NanoTemper news, product updates, event announcements and more

First Name
Last Name
Company Name
Agree to Subscribe & Privacy Policy*
*I have fully read, understood and agree to the Privacy Policy. I accept the storing and processing of my personal data by NanoTemper as described in the Privacy Policy.

By completing this form, you provide us consent to contact you with educational content, news and information about our products, services and events. You may unsubscribe at any time.
Thank you!
Error - something went wrong!

Monitoring the impact of storage-dependent denaturation on protein quality using Tycho NT.6

Expression and purification are critical steps in protein discovery and characterization workflows. Equally important in the workflow is the optimization of storage conditions that will ensure protein stability. Unfortunately, researchers spend little effort evaluating the effects of storage on the quality of samples prepared in-house or of those obtained through commercial vendors, which can be attributed in part to the lack of quick and simple quality check methods.

Tycho NT.6 records precise thermal unfolding profiles of proteins in as little as three minutes, so researchers can quickly detect the presence of unfolded protein in their samples before it is used in an assay and negatively impacts the outcome. In this technical note, we show how such a storage-dependent increase in the amount of unfolded protein directly affects the quality of biophysical assays, highlighting the importance of rigorous quality checks.

Previous Video
Introducing Tycho NT.6 - 3 minutes will change everything
Introducing Tycho NT.6 - 3 minutes will change everything

Know protein quality first and stop doing unnecessary experiments. Wonder why you’re having trouble repro...

Up next
Tycho named one of the Top 10 Innovations of 2018 by The Scientist
Tycho named one of the Top 10 Innovations of 2018 by The Scientist

We’re thrilled that Tycho is named one of the winners in The Scientist’s Top 10 Innovations of 2018 contest...

See what Tycho looks like and find out how to run an assay

Get to know Tycho