Tycho | Protein Quality

NanoTemper has discontinued Tycho as of January 1, 2023. If you were interested in Tycho, we suggest you see Prometheus to learn about our solutions for protein stability, aggregation, and particle sizing characterization.

  • The NanoTemper Story – Chapter 4: The Tycho

    The NanoTemper Story – Chapter 4: The Tycho

    The Tycho was developed to help protein researchers better understand how their proteins are behaving. The Prometheus is great for advanced biophysical characterization, but sometimes all a...

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  • Capsid lattice destabilization leads to premature loss of the viral genome and integrase enzyme during HIV-1 infection

    Capsid lattice destabilization leads to premature loss of the viral genome and integrase enzyme during HIV-1 infection

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  • 4 SPR assay problems that can be resolved by improving protein quality

    4 SPR assay problems that can be resolved by improving protein quality

    Surely you’ve found yourself in a research situation where your experimental results left you scratching your head. Any type of lab work will sometimes do that to you, and Surface Plasmon...

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  • Why you should consider subscribing to research instruments instead of buying

    Why you should consider subscribing to research instruments instead of buying

    In recent years, subscriptions have become more and more popular. Chances are you have some too — maybe you have a subscription to your favorite video or music streaming service, or you have a...

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  • Accelerating Protein Purification by Using Thermal Unfolding as a Guiding Tool45:48

    Accelerating Protein Purification by Using Thermal Unfolding as a Guiding Tool

    Cellular expression and purification of proteins are among the most widely used techniques in biology. Expressing proteins in stable, properly-folded states is a challenge that may be abated by monito

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  • 5 publications that put protein quality checks into the workflow, using Tycho

    5 publications that put protein quality checks into the workflow, using Tycho

    By providing a better understanding of the quality of their samples, Tycho helped prevent unnecessary experiments, minimize questionable data, and change how scientists approach experiments. Here...

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  • Cyrill Brunner gets Explorer Award for innovative approach to advance drug discovery research using computer modeling

    Cyrill Brunner gets Explorer Award for innovative approach to advance drug discovery research using computer modeling

    Meet Cyrill Brunner, Senior PhD candidate at ETH in Zurich, Switzerland (preparing to defend his thesis as we go to press) and one of the 2019 Explorer award recipients. This award is given to...

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  • Thermal unfolding and refolding of a lytic polysaccharide monooxygenase from Thermoascus aurantiacus

    Thermal unfolding and refolding of a lytic polysaccharide monooxygenase from Thermoascus aurantiacus

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  • Functionally critical residues in the aminoglycoside resistance-associated methyltransferase RmtC play distinct roles

    Functionally critical residues in the aminoglycoside resistance-associated methyltransferase RmtC play distinct roles

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  • Molecular basis for the binding and selective dephosphorylation of Na+/H+ exchanger 1 by calcineurin

    Molecular basis for the binding and selective dephosphorylation of Na+/H+ exchanger 1 by calcineurin

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  • Validation of Tycho NT.6 precision and repeatability

    Validation of Tycho NT.6 precision and repeatability

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  • What you wish you knew before storing your protein in the freezer

    What you wish you knew before storing your protein in the freezer

    Contrary to what many researchers may think, there is no universal storage practice that can be applied to all proteins that ensure their integrity will indefinitely be maintained. In fact,...

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  • Kinetic and structural analysis of human ALDH9A1

    Kinetic and structural analysis of human ALDH9A1

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  • Validation of protein complex functionality with Tycho NT.6

    Validation of protein complex functionality with Tycho NT.6

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  • 3 ways to know your protein purification is a success

    3 ways to know your protein purification is a success

    With any experiment, it’s important to standardize the steps to ensure consistent results. Let’s take a look at three metrics that are commonly monitored and should be measured during any protein...

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  • Repeatability assessment of Tycho NT.6 for better protein quality checks

    Repeatability assessment of Tycho NT.6 for better protein quality checks

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  • Quick protein binding analysis by label-free thermal shift analysis on the Tycho NT.6

    Quick protein binding analysis by label-free thermal shift analysis on the Tycho NT.6

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  • Monitoring the impact of storage-dependent denaturation on protein quality using Tycho NT.6

    Monitoring the impact of storage-dependent denaturation on protein quality using Tycho NT.6

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  • Tycho named one of the Top 10 Innovations of 2018 by The Scientist

    Tycho named one of the Top 10 Innovations of 2018 by The Scientist

    We’re thrilled that Tycho is named one of the winners in The Scientist's Top 10 Innovations of 2018 contest. We’re even further honored that the panel of independent judges — who represent the...

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  • Better optimization of biosensor assay development with Tycho NT.6

    Better optimization of biosensor assay development with Tycho NT.6

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