Tycho | Protein Quality

Capsid lattice destabilization leads to premature loss of the viral genome and integrase enzyme during HIV-1 infection

4 SPR assay problems that can be resolved by improving protein quality

Like in any analytical assay, the quality of SPR results depends heavily on the quality of the starting material. Don’t believe it? Here’s 4 situations that may sound familiar, where taking a step...

Why you should consider subscribing to research instruments instead of buying

In recent years, subscriptions have become more and more popular. Chances are you have some too — maybe you have a subscription to your favorite video or music streaming service, or you have a...

5 publications that put protein quality checks into the workflow, using Tycho

By providing a better understanding of the quality of their samples, Tycho helped prevent unnecessary experiments, minimize questionable data, and change how scientists approach experiments. Here...

Cyrill Brunner gets Explorer Award for innovative approach to advance drug discovery research using computer modeling

Meet Cyrill Brunner, Senior PhD candidate at ETH in Zurich, Switzerland (preparing to defend his thesis as we go to press) and one of the 2019 Explorer award recipients. This award is given to...

Thermal unfolding and refolding of a lytic polysaccharide monooxygenase from Thermoascus aurantiacus

Functionally critical residues in the aminoglycoside resistance-associated methyltransferase RmtC play distinct roles

Molecular basis for the binding and selective dephosphorylation of Na+/H+ exchanger 1 by calcineurin

What you wish you knew before storing your protein in the freezer

Contrary to what many researchers may think, there is no universal storage practice that can be applied to all proteins that ensure their integrity will indefinitely be maintained. In fact,...

Kinetic and structural analysis of human ALDH9A1

3 ways to know your protein purification is a success

With any experiment, it’s important to standardize the steps to ensure consistent results. Let’s take a look at three metrics that are commonly monitored and should be measured during any protein...

Tycho named one of the Top 10 Innovations of 2018 by The Scientist

We’re thrilled that Tycho is named one of the winners in The Scientist's Top 10 Innovations of 2018 contest. We’re even further honored that the panel of independent judges — who represent the...