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Measure binding affinities for any type of interaction — examine a label-free or labeled target molecule at anytime

The combination of LabelFree and RED detectors in the Monolith Pico instrument provides scientists with the ability to characterize almost any type of interaction. Where binding affinity quantification under native conditions is preferred, label-free MST can be performed. In other circumstances, measuring a labeled target is desired and the RED channel is useful for measuring any interaction, even the most challenging ones — those involving ternary complexes or interactions in cell lysate or serum — while using very little sample. Having both detectors in one instrument provides the highest versatility and flexibility of all Monolith instruments, enabling scientists to freely choose the most appropriate approach for their project.

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Understanding the nuances of targeted protein degradation
Understanding the nuances of targeted protein degradation

Bifunctional degrader molecules (also known as PROTACs) and molecular glues recruit proteins to E3 ubiquiti...

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Let's catalyze - biophysical insights into enzymes
Let's catalyze - biophysical insights into enzymes

Enzymes are nature's engine for many processes. Diving into the stability and function of enzymes will give...

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