The combination of LabelFree and RED detectors in the Monolith Pico instrument provides scientists with the ability to characterize almost any type of interaction. Where binding affinity quantification under native conditions is preferred, label-free MST can be performed. In other circumstances, measuring a labeled target is desired and the RED channel is useful for measuring any interaction, even the most challenging ones — those involving ternary complexes or interactions in cell lysate or serum — while using very little sample. Having both detectors in one instrument provides the highest versatility and flexibility of all Monolith instruments, enabling scientists to freely choose the most appropriate approach for their project.
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