Isoform-Selective ATAD2 chemical probe with novel chemical structure and unusual mode of action

October 18, 2017

Fernández-Montalván, A., Berger, M., Kuropka, B., et al.

American Chemical Society 2017, vol: 12(11) doi: 10.1021/acschembio.7b00708

Abstract

ATAD2 (ANCCA) is an epigenetic regulator and transcriptional cofactor, whose overexpression has been linked to the progress of various cancer types. Here, we report a DNA-encoded library screen leading to the discovery of BAY-850, a potent and isoform selective inhibitor that specifically induces ATAD2 bromodomain dimerization and prevents interactions with acetylated histones in vitro, as well as with chromatin in cells. These features qualify BAY-850 as a chemical probe to explore ATAD2 biology.

View Publication
 

Topics: Monolith – MicroScale Thermophoresis, MST,  Publications

 

 

 

Previous Article
Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2
Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2

Up next
4 studies highlight the impact of biophysical tools in plant science research
4 studies highlight the impact of biophysical tools in plant science research

Plant research paves the way for important advances in agriculture, ecology, and medicine. As an example, d...

Have a question about Monolith?

Contact Specialist
×

Sign up to receive
the latest NanoTemper news, product updates, event announcements and more

First Name
Last Name
Company Name
Country
State
Province
State
Region
State
Canton
Agree to Subscribe & Privacy Policy*
*I have fully read, understood and agree to the Privacy Policy. I accept the storing and processing of my personal data by NanoTemper as described in the Privacy Policy.

By completing this form, you provide us consent to contact you with educational content, news and information about our products, services and events. You may unsubscribe at any time.
Thank you!
Error - something went wrong!