Targeted protein degradation promises to lead the way to effective drugs for challenging targets

May 7, 2021

Researchers are using targeted protein degradation as a strategy to develop drugs that target disease-causing proteins where traditional inhibitor drugs can’t be used. 

In this infographic, we discuss both inhibition and degradation, the advantages and challenges related to each approach, and the key points you need to consider when designing your protein degraders. 

 

Learn how researchers are using NanoTemper tools to evaluate the affinity and specificity of their PROTAC candidate.

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Understanding the nuances of targeted protein degradation
Understanding the nuances of targeted protein degradation

Bifunctional degrader molecules (also known as PROTACs) and molecular glues recruit proteins to E3 ubiquiti...

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