End of last year, Sanofi and NanoTemper Technologies released a publication describing an automated MicroScale Thermophoresis (MST) affinity screening approach to identify fragments active against the cancer target MEK1 kinase.
15:19The tool you choose to measure affinities should tackle a diverse range of targets and ligands that come your way — such as GPCRs, IDPs, or cancer-related proteins. And, you should get data that help
0:40In this short animated video, learn the basics of how antibody-drug conjugates (ADCs) are engineered and why that makes them such powerful tools to target cancers with precision.
12:54Dianthus is a biophysical screening instrument that uses Spectral Shift technology to measure molecular interactions for hit ID, hit-to-lead, and lead optimization. It offers a 384-well plate format a
4:51The decisions you make about your biologics candidates early in the pipeline ultimately affect their success as therapeutics. Combine sizing and stability information to develop successful biologics
9:42Your protein stability characterization projects require tools that provide high-precision, high-quality data to support your selection process. Watch this 10 min walkthrough of Prometheus Panta.
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1:41Choosing the right stability characterization tool for your biologics research is a big commitment. You’re going to be screening and optimizing lots of candidates, and you’ll need data on thermal stab
2:46Learn what attributes Prometheus users considered a must-have and how we made sure to preserve them when integrating and implementing new biophysical techniques. Prometheus Panta gives you the ability
2:34Discover how 2bind applied multi-parameter characterization from a single experiment to find the optimal buffer for a vaccine antigen target.
14:07When you develop an AAV therapeutic, you need to assess many key parameters, or Critical Quality Attributes (CQAs), in order to track progress and, ultimately, get your therapeutic approved. As part
1:31Discover how Janssen improved the stability of a promising prostate cancer targeting mAb. You’ll learn why it is important to optimize stability measurements of a therapeutic mAb.
1:39Discover how Coriolis Pharma found the best excipients to stabilize their monoclonal antibodies for long-term storage. You’ll learn about the importance of expanding the chemical space for excipients
3:59PR.Stability Analysis offers a great feature to dramatically reduce the amount of time you spend processing your Prometheus data. With Key Parameters, it is possible to quickly and reliably calculate
4:06PR.Stability Analysis software offers a great new feature—Percent Similarity— that is used to analyze how your formulations and preparations compare to earlier experiments. It enables you to get quant
4:36Data analysis is a challenging process—researchers have mountains of data to go through—and expediting analysis with automated software solutions is a crucial tool to save you time and effort. However
4:20Personalize your data by adding and removing markers in your datasets using PR.Stability Analysis software When looking at large data sets, it is not easy to go through each individual unfolding curv
5:55Anyone who has ever worked in a lab has heard the same refrain in some context or another – “We need more data!" No matter how many experiments you do, it feels like reviewers, regulators, or even you
4:09Working with difficult targets like GPCRs and other membrane proteins? Because they live in the cell membrane, are hydrophobic and insoluble, have low expression levels, and require particular deter
5:02The scientific method can be a long, arduous process, but there are many tools available to researchers to make data analysis less daunting. PR.Stability Analysis software was designed to enable Prom
