Dianthus is a biophysical screening instrument that uses Spectral Shift technology to measure molecular interactions for hit ID, hit-to-lead, and lead optimization. It offers a 384-well plate format and can be readily integrated into any automation solutions — from robotic pipeters to plate feeders.
In this 13-minute video, Application Scientist Jan Schnatwinkel presents a case study that used Dianthus to screen a small molecule library — from single-dose to lead validation — in a fully automated setup.
Here’s what Jan shares in this video:
- The detailed 2-day project timeline
- The experimental setup, which includes checking for target quality control and measurement of the positive control binding affinity
- A brief walkthrough of the software where you can appreciate how the results are presented, how to interpret the results, and the export options