Tackle the high-hanging fruits in challenging drug discovery pipelines

There are a number of interesting drug targets that have a reputation of being especially difficult to study in biochemical or biophysical assays. Join us to learn how Dianthus can help you address these targets with a quantitative, biophysical assay in 384-well format. Find out how Dianthus is used to study molecular interactions with these challenging targets: 

  • Fragment screen for dimeric receptor STING
  • Protein-peptide interaction, where the target is a scaffolding protein of the postsynaptic density, a membrane anchored protein
  • A multi-component interactions with PROTACs
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Understanding the nuances of targeted protein degradation
Understanding the nuances of targeted protein degradation

Bifunctional degrader molecules (also known as PROTACs) and molecular glues recruit proteins to E3 ubiquiti...

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Sweet and blind spots in E3 ligase ligand space revealed by a thermophoresis-based assay
Sweet and blind spots in E3 ligase ligand space revealed by a thermophoresis-based assay

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