The stability of biopharmaceuticals is a complex mixture of parameters and plays a crucial role throughout the entire product lifecycle, from discovery through production and manufacturing. Making critical decisions that determine the success of a biopharmaceutical requires clear and precise results.
In this two-part webinar, Dr. Jie Wen (Sr. Scientist, Higher Order Structure, Biological Relevance and Characterization, Attribute Sciences Amgen) discusses the advantages of nanoDSF for thermal stability analysis with examples of applications such as developability and formulation studies as well as comparability studies of therapeutic proteins. Then, Dr. Charles Heffern (Product Manager, NanoTemper) presents how Prometheus empowers experienced organizations to improve their biologic discovery and development by using high-quality data to make better decisions.
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Join this conversation to gain insight into how the Analytical and Formulation Sciences team at Thermo Fisher Scientific approaches stability assessment of biologic, and how the Prometheus Panta helps
The work of pre-formulations scientists is critical to de-risk the entire development process for biologics. Read on to learn more about what to consider about your buffer components for...
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Developability assessment is a critical part of the evaluation and selection of candidates for further optimization and development for biologics researchers. This work entails collecting, ranking, an
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In this video, Nathan Wallace, Application Specialist at NanoTemper, addresses common questions about experimental design for developability profiling and the operation of Prometheus Panta.
For antibody-drug conjugate (ADC) development, scientists rely on stability experiments using fluorescence and light scattering techniques to predict the conjugated molecule's behavior.
Learn how it’s possible to use the Prometheus Panta to extrapolate how your low concentration sample will behave once it’s scaled up and at higher concentrations used for clinical administration.
Characterize the developability of antibody-drug conjugates: Multi-parameter stability assessment with Prometheus Panta makes it possible to examine multiple aspects of ADC stability in parallel.
Read this nanoDSF guide to learn how nano-Differential Scanning Fluorimetry (nanoDSF) uses your protein’s intrinsic fluorescence to determine its melting temperature, Tm and onset of melting, Ton.
Thermal stability screening is a common approach used to study the developability of a wide range of protein-based therapeutics. Among the different technologies available to perform thermal stability
Learn about Differential Scanning Calorimetry (DSC), Circular Dichroism (CD), Extrinsic Differential Scanning Fluorimetry, and nano-Differential Scanning Fluorimetry for thermal stability of proteins