Use of high-throughput methods for early stage formulation evaluation and their correlation to stability studies

AbbVie preformulation is an early discovery biologics group working to optimise antibodies prior to downstream assays and clinical delivery.

Join Brittney Mills, PhD, as she explains how AbbVie uses the Prometheus to evaluate conformational and colloidal stability of their candidates. She will discuss the goals of their early formulations group; how Prometheus nanoDSF compares to DSC and its advantages in material usage; the predictive merits of data derived from Prometheus; and how accelerated stability studies validate the initial screening parameters.

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Sizing accuracy and intra-assay precision of DLS measurements with Prometheus Panta
Sizing accuracy and intra-assay precision of DLS measurements with Prometheus Panta

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Peptide-MHC I complex stability measured by nanoscale differential scanning fluorimetry reveals molecular mechanism of thermal denaturation
Peptide-MHC I complex stability measured by nanoscale differential scanning fluorimetry reveals molecular mechanism of thermal denaturation

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