Scientists in the field of drug discovery, particularly biologics, use DLS to make critical decisions about drug candidate stability. This creates a need for instruments that exhibit strong sizing accuracy and precision. These properties can be evaluated using standards and references from the National Institute of Standards and Technology (NIST). Here, the NIST monoclonal antibody (NISTmAb) reference material (RM) RM8671, Lysozyme, and a set of monodisperse particle size standards were used to test the sizing accuracy and intra-assay precision of Prometheus Panta’s DLS optical module.
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17:08Assess the impact of conjugation with multi-parameter stability characterization
Characterize the developability of antibody-drug conjugates: Multi-parameter stability assessment with Prometheus Panta makes it possible to examine multiple aspects of ADC stability in parallel.
Get predictive insight into your ADC’s stability with these 3 experiments
When developing ADCs, there are some strategies for protein assessment that will help mitigate the risk of destabilizing the final product during early development, particularly when optimizing...
19:07How stability prediction experiments give you confidence in your ADCs
For antibody-drug conjugate (ADC) development, scientists rely on stability experiments using fluorescence and light scattering techniques to predict the conjugated molecule's behavior.
0:40What are ADCs and how do they work against cancer?
In this short animated video, learn the basics of how antibody-drug conjugates (ADCs) are engineered and why that makes them such powerful tools to target cancers with precision.
De-risk your ADC development process with these stability considerations
Antibody-drug conjugates, or ADCs, are revolutionary therapeutics that represent a growing proportion of the biologics market. They combine the targeting power of a monoclonal antibody, which is...
19:16How to mitigate risk during ADC development with multi-parameter stability characterization
To assess the developability properties of antibody-drug conjugates (ADCs) learn about multi-parameter characterization of thermal and colloidal stability with Prometheus Panta using nanoDSF and DLS
5 biologics conferences you won’t want to miss in 2024
Use this list of crowd-sourced favorites to kick-start your 2024 biologics conference plans. Find out when and where each conference takes place, who will be there, which topics are covered, and...
4:51Four integrated technologies for biologics developability assessment
The decisions you make about your biologics candidates early in the pipeline ultimately affect their success as therapeutics. Combine sizing and stability information to develop successful biologics
How four stability assessment technologies support biologics early development
During early development of biologics, there are many attributes scientists evaluate for developability. Measure them with biophysical characterization using nanoDSF, DLS, backreflection, and SLS.
38:20Conversation: How Aaron Frimel from Thermo Fisher Scientific approaches biologics formulation
Join this conversation to gain insight into how the Analytical and Formulation Sciences team at Thermo Fisher Scientific approaches stability assessment of biologic, and how the Prometheus Panta helps
38:31nanoDSF for biologics: How to interpret thermal unfolding profiles for your different applications
Thermal stability screening is a common approach used to study the developability of a wide range of protein-based therapeutics. Among the different technologies available to perform thermal stability
24:28Thermal stability measurements for biologics developability profiling
Learn about four methods for thermal stability measurements: DSC, CD, DSF and nanoDSF. You'll review their pros and cons, what they data tell you and why it's important for biologics developability.
Why nanoDSF is the preferred method to assess the thermal stability of your therapeutic proteins
Learn about Differential Scanning Calorimetry (DSC), Circular Dichroism (CD), Extrinsic Differential Scanning Fluorimetry, and nano-Differential Scanning Fluorimetry for thermal stability of proteins
The biologics researcher's mini-guide to screening candidates with nanoDSF
Read this nanoDSF guide to learn how nano-Differential Scanning Fluorimetry (nanoDSF) uses your protein’s intrinsic fluorescence to determine its melting temperature, Tm and onset of melting, Ton.
How stability characterization parameters help you create biologics developability profiles
Developability profiles help you avoid risk by collecting many quality attributes associated with each candidate, enabling you to rank each candidate by the most optimal attributes and make a...
21:31How biologics teams approach developability screening of their candidates with combinatorial stability characterization
Full developability profiles de-risk the selection process for biologics candidates during early development workflows. There are many critical quality attributes to evaluate when it comes to developa
20:19Explore Prometheus Panta – Biologics developability assessment with four integrated technologies
Developability assessment is a critical part of the evaluation and selection of candidates for further optimization and development for biologics researchers. This work entails collecting, ranking, an
How to predict your biologics candidates' behavior at high concentrations with light-scattering techniques
Light scattering techniques are used to predict high-concentration behavior of candidates early in the development process. Let's take a look at what they tell you, how to set them up, and how...
17:33How to use light scattering techniques to predict your biologic's self-association behavior at high concentrations
Developability work requires the assessment of multiple critical quality attributes (CQAs) of your biologics. Many of these CQAs are measured or monitored using low-volume, low-concentration samples.