Everyday researchers face the daunting challenge of creating more effective biotherapeutics. Many candidates fail due to a lack of critical stability information that’s tightly linked to function and efficacy. Scientists deserve a technology early on in their research that reveals deep bioanalytical characterization. Prometheus quickly and precisely measures conformational and colloidal stability of any protein. Examples of optimizing storage/buffer formulation conditions and functional screening to identify better biotherapeutic targets using Prometheus will be discussed.
Ready to tackle your challenging stability characterizations?
Discover toolsSee more related content
![De-risk your antibody characterization workflows with high-quality, multi-parameter stability data from Prometheus Panta](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fres.cloudinary.com%2Fuf-553493%2Fimage%2Fupload%2Fv1716468987%2FUberflip_Thumbnail_ert2xy.png&size=1&version=1716469212&sig=df3c439708b93ebbd43ef4c1ecc3ce7e&default=hubs%2Ftilebg-videos.jpg)
Get developability profiles for monoclonal antibodies with stability data from Prometheus Panta to inform on rational design and selection of therapeutic constructs that will succeed in the clinic.
![Biologics Formulation: Select optimal buffer conditions with multi-parameter stability characterization from Prometheus Panta](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fcontent.cdntwrk.com%2Ffiles%2FaHViPTg2NTQ5JmNtZD1pdGVtZWRpdG9yaW1hZ2UmZmlsZW5hbWU9aXRlbWVkaXRvcmltYWdlXzY2MmZkZmJjOTJmZjYucG5nJnZlcnNpb249MDAwMCZzaWc9OGYxOGQ0ODg5ZTVhYjJkNzVlYjI1MmU5MDI0OWNjOGY%25253D&size=1&version=1714413510&sig=e7113872c465e6d045c346261714b0f9&default=hubs%2Ftilebg-videos.jpg)
Learn how to identify optimal buffer conditions during pre-formulation, with multi-parameter stability characterization from Prometheus Panta, a tool to collect thermal and colloidal data while saving
![5 considerations for buffer optimization during biologics pre-formulation](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fnanotempertech.com%2Fwp-content%2Fuploads%2F2024%2F05%2FAdobeStock_599334474-scaled.jpeg&size=1&version=1720514632&sig=4efcbf35ba24076301419c63e6879d61&default=hubs%2Ftilebg-blogs.jpg)
The work of pre-formulations scientists is critical to de-risk the entire development process for biologics. Read on to learn more about what to consider about your buffer components for...
![5 types of formulation excipients and how they impact biologics stability](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fnanotempertech.com%2Fwp-content%2Fuploads%2F2024%2F05%2FAdobe-stock-image-test-tubes-blog.png&size=1&version=1718397767&sig=89bdab4cc57b798cc127758303da3267&default=hubs%2Ftilebg-blogs.jpg)
For pre-formulations researchers looking to find buffers that stabilize early development biologic products, buffer optimization goes beyond the pH and salt concentration of the solution....
![Four integrated technologies for biologics developability assessment](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fcontent.cdntwrk.com%2Ffiles%2FaHViPTg2NTQ5JmNtZD1pdGVtZWRpdG9yaW1hZ2UmZmlsZW5hbWU9aXRlbWVkaXRvcmltYWdlXzYzOTg4NzgyNTAxNGMuanBlZyZ2ZXJzaW9uPTAwMDAmc2lnPWFiMTc1ZTJhZmRmZGY1ZTBjZTY4YzgyMjMxMDAwMGY5&size=1&version=1713519251&sig=b3f93dee9e36d2d9624e2a9ab20463b2&default=hubs%2Ftilebg-videos.jpg)
The decisions you make about your biologics candidates early in the pipeline ultimately affect their success as therapeutics. Combine sizing and stability information to develop successful biologics
![Virtual Prometheus Panta demo: Four integrated technologies for protein stability characterization](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fcontent.cdntwrk.com%2Ffiles%2FaHViPTg2NTQ5JmNtZD1pdGVtZWRpdG9yaW1hZ2UmZmlsZW5hbWU9aXRlbWVkaXRvcmltYWdlXzY2MTZlZmI1YTBjN2QucG5nJnZlcnNpb249MDAwMCZzaWc9OGQ0NzhiMzlmZWVmMmFkOGFmMzExZGRkMTBkN2E5NTA%25253D&size=1&version=1713515900&sig=a924af6687fb3777fc9ed363be143493&default=hubs%2Ftilebg-videos.jpg)
Your protein stability characterization projects require tools that provide high-precision, high-quality data to support your selection process. Watch this 10 min walkthrough of Prometheus Panta.
![Conversation: How Aaron Frimel from Thermo Fisher Scientific approaches biologics formulation](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fcontent.cdntwrk.com%2Ffiles%2FaHViPTg2NTQ5JmNtZD1pdGVtZWRpdG9yaW1hZ2UmZmlsZW5hbWU9aXRlbWVkaXRvcmltYWdlXzY1Njg5NWUxNmE0MTUucG5nJnZlcnNpb249MDAwMCZzaWc9YmI5OTZkNmY1YWQ2M2U2Y2NmOWJlNGM2OTYzOGUyZGU%25253D&size=1&version=1701353040&sig=760f4216303ee3c862160680eae99ae2&default=hubs%2Ftilebg-videos.jpg)
Join this conversation to gain insight into how the Analytical and Formulation Sciences team at Thermo Fisher Scientific approaches stability assessment of biologic, and how the Prometheus Panta helps
![Explore Prometheus Panta – Biologics developability assessment with four integrated technologies](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fcontent.cdntwrk.com%2Ffiles%2FaHViPTg2NTQ5JmNtZD1pdGVtZWRpdG9yaW1hZ2UmZmlsZW5hbWU9aXRlbWVkaXRvcmltYWdlXzY0ZTMyN2JjMzA1MGEucG5nJnZlcnNpb249MDAwMCZzaWc9ZmE3MzU4N2RlMGQ1MDNiNWEzNjIzMDUzZjdkNGRjNTE%25253D&size=1&version=1692867213&sig=9a7465d3b3db60eb1f6f763bfc2ab00d&default=hubs%2Ftilebg-videos.jpg)
Developability assessment is a critical part of the evaluation and selection of candidates for further optimization and development for biologics researchers. This work entails collecting, ranking, an
![Explore Prometheus Panta – Frequently asked questions about stability profiling experiments](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fcontent.cdntwrk.com%2Ffiles%2FaHViPTg2NTQ5JmNtZD1pdGVtZWRpdG9yaW1hZ2UmZmlsZW5hbWU9aXRlbWVkaXRvcmltYWdlXzY0ZTcxYjljN2VkYTUucG5nJnZlcnNpb249MDAwMCZzaWc9NTMxMzllMjYwNDQxY2IyZWQxZjEwZGEyOTNkOGU5MTE%25253D&size=1&version=1692867545&sig=ba087357d9120c46a5c3b32022eefb8d&default=hubs%2Ftilebg-videos.jpg)
In this video, Nathan Wallace, Application Specialist at NanoTemper, addresses common questions about experimental design for developability profiling and the operation of Prometheus Panta.
![Prometheus Panta: The new gold standard for biologics characterization](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fcontent.cdntwrk.com%2Ffiles%2FaHViPTg2NTQ5JmNtZD1pdGVtZWRpdG9yaW1hZ2UmZmlsZW5hbWU9aXRlbWVkaXRvcmltYWdlXzYyMWQ2YzAyMDg3ZDMucG5nJnZlcnNpb249MDAwMCZzaWc9ZjQ3Mjg5NGM4ZDMyYTRjNGYxMzM1MjU1YjlmMjU0MWY%25253D&size=1&version=1665679078&sig=24ae2c1c167fd4b667c1a5dc7d8e9650&default=hubs%2Ftilebg-videos.jpg)
Choosing the right stability characterization tool for your biologics research is a big commitment. You’re going to be screening and optimizing lots of candidates, and you’ll need data on thermal stab
![Assess the impact of bioconjugation with multi-parameter stability characterization](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fcontent.cdntwrk.com%2Ffiles%2FaHViPTg2NTQ5JmNtZD1pdGVtZWRpdG9yaW1hZ2UmZmlsZW5hbWU9aXRlbWVkaXRvcmltYWdlXzY1ZjliNDgxNmQ1NzQucG5nJnZlcnNpb249MDAwMCZzaWc9MWNhOTdkMDc3OWNkYjJmZjdiZjAwMjg5OWM3OGRjNjY%25253D&size=1&version=1714412448&sig=330d90a750b1cef76374a164ef6a281c&default=hubs%2Ftilebg-videos.jpg)
Characterize the developability of antibody-drug conjugates: Multi-parameter stability assessment with Prometheus Panta makes it possible to examine multiple aspects of ADC stability in parallel.
![nanoDSF for biologics: How to interpret thermal unfolding profiles for your different applications](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fcontent.cdntwrk.com%2Ffiles%2FaHViPTg2NTQ5JmNtZD1pdGVtZWRpdG9yaW1hZ2UmZmlsZW5hbWU9aXRlbWVkaXRvcmltYWdlXzY1MTU2Mjk4OGFkYTYucG5nJnZlcnNpb249MDAwMCZzaWc9YWMyMDUwYmEwNzA4ZmJjMTA2OTdjZGJhZGE0NDcxZTA%25253D&size=1&version=1715958626&sig=46a94f2734cb38e896b6c7d7ba057c8e&default=hubs%2Ftilebg-videos.jpg)
Thermal stability screening is a common approach used to study the developability of a wide range of protein-based therapeutics. Among the different technologies available to perform thermal stability
![Why nanoDSF is the preferred method to assess the thermal stability of your therapeutic proteins](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fcontent.cdntwrk.com%2Ffiles%2FaHViPTg2NTQ5JmNtZD1pdGVtZWRpdG9yaW1hZ2UmZmlsZW5hbWU9aXRlbWVkaXRvcmltYWdlXzY1OWZmYWI4MTQ1NTIucG5nJnZlcnNpb249MDAwMCZzaWc9ZDRhNmY2NDYzNDExYWU4MTY3MThlOTMzM2YxYmYzY2Q%25253D&size=1&version=1704983235&sig=e79dd284a547082b5a4fc63c36a51fa2&default=hubs%2Ftilebg-blogs.jpg)
Learn about Differential Scanning Calorimetry (DSC), Circular Dichroism (CD), Extrinsic Differential Scanning Fluorimetry, and nano-Differential Scanning Fluorimetry for thermal stability of proteins
![Thermal stability measurements for biologics developability profiling](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fcontent.cdntwrk.com%2Ffiles%2FaHViPTg2NTQ5JmNtZD1pdGVtZWRpdG9yaW1hZ2UmZmlsZW5hbWU9aXRlbWVkaXRvcmltYWdlXzY1MDBiNzI5MDM5MjYucG5nJnZlcnNpb249MDAwMCZzaWc9ZWNlOTAzMWY4MGQ0OGI3MzM0NTQ3OTQwZTBkMDU2Mjg%25253D&size=1&version=1709636630&sig=d86c8fb5a16acca0f7210ecb0b30a3a1&default=hubs%2Ftilebg-videos.jpg)
Learn about four methods for thermal stability measurements: DSC, CD, DSF and nanoDSF. You'll review their pros and cons, what they data tell you and why it's important for biologics developability.
![The biologics researcher's mini-guide to screening candidates with nanoDSF](https://content.cdntwrk.com/files/aT0xNDk4ODUwJnA9MCZ2ZXJzaW9uPTEmY21kPXYmc2lnPTljZjdlNjFmYWRkZGI0N2QyMzU1OTIxYzgxYzM2ZjZk/-w-320.jpg)
Read this nanoDSF guide to learn how nano-Differential Scanning Fluorimetry (nanoDSF) uses your protein’s intrinsic fluorescence to determine its melting temperature, Tm and onset of melting, Ton.
![How stability prediction experiments give you confidence in your ADCs](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fcontent.cdntwrk.com%2Ffiles%2FaHViPTg2NTQ5JmNtZD1pdGVtZWRpdG9yaW1hZ2UmZmlsZW5hbWU9aXRlbWVkaXRvcmltYWdlXzY1ZTZmZDYzNDU0MTgucG5nJnZlcnNpb249MDAwMCZzaWc9MGM1ZGRmN2ZmYzdjZmUyYTViODI3ZmE1OWQyYTM2MTY%25253D&size=1&version=1715958612&sig=3b6a68bd993d755ae01d447a96466cb2&default=hubs%2Ftilebg-videos.jpg)
For antibody-drug conjugate (ADC) development, scientists rely on stability experiments using fluorescence and light scattering techniques to predict the conjugated molecule's behavior.
![Get predictive insight into your ADC’s stability with these 3 experiments](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fnanotempertech.com%2Fwp-content%2Fuploads%2F2024%2F03%2FAdobeStock_453943865-scaled.jpeg&size=1&version=1720526038&sig=786dfe08242a004607249257b2080e71&default=hubs%2Ftilebg-blogs.jpg)
Learn how it’s possible to use the Prometheus Panta to extrapolate how your low concentration sample will behave once it’s scaled up and at higher concentrations used for clinical administration.
![How to mitigate risk during ADC development with multi-parameter stability characterization](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fcontent.cdntwrk.com%2Ffiles%2FaHViPTg2NTQ5JmNtZD1pdGVtZWRpdG9yaW1hZ2UmZmlsZW5hbWU9aXRlbWVkaXRvcmltYWdlXzY1MzdjOGYzOWU1YmMucG5nJnZlcnNpb249MDAwMCZzaWc9ZDRlMjY4YzBhYTFkZDc2ZmY0MGUzMTYwMjZkNDE5ZmU%25253D&size=1&version=1709636476&sig=e160a5a2f2da8b58f82159f13e5020e5&default=hubs%2Ftilebg-videos.jpg)
To assess the developability properties of antibody-drug conjugates (ADCs) learn about multi-parameter characterization of thermal and colloidal stability with Prometheus Panta using nanoDSF and DLS
![De-risk your ADC development process with these stability considerations](https://content.cdntwrk.com/mediaproxy?url=https%3A%2F%2Fnanotempertech.com%2Fwp-content%2Fuploads%2F2023%2F12%2FBlog-Cropping-Official.jpg&size=1&version=1709636440&sig=36e9db54191503c1e5578d9051e9b088&default=hubs%2Ftilebg-blogs.jpg)
Antibody-drug conjugates, or ADCs, are revolutionary therapeutics that represent a growing proportion of the biologics market. They combine the targeting power of a monoclonal antibody, which is...