Use this eBook to advance your own neurodegenerative diseases (ND) research by reading a selection of peer-reviewed publications. Find out how researchers are gaining insight into the molecular mechanisms of protein misfolding and aggregation — a hallmark of ND — by analyzing molecular interactions and thermal stability using MicroScale Thermophoresis (MST) and nanoDSF.
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17:08Assess the impact of conjugation with multi-parameter stability characterization
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4:51Four integrated technologies for biologics developability assessment
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9:42Virtual Prometheus Panta demo: Four integrated technologies for protein stability characterization
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38:20Conversation: How Aaron Frimel from Thermo Fisher Scientific approaches biologics formulation
Join this conversation to gain insight into how the Analytical and Formulation Sciences team at Thermo Fisher Scientific approaches stability assessment of biologic, and how the Prometheus Panta helps
20:19Explore Prometheus Panta – Biologics developability assessment with four integrated technologies
Developability assessment is a critical part of the evaluation and selection of candidates for further optimization and development for biologics researchers. This work entails collecting, ranking, an
8:38Explore Prometheus Panta – Frequently asked questions about stability profiling experiments
In this video, Nathan Wallace, Application Specialist at NanoTemper, addresses common questions about experimental design for developability profiling and the operation of Prometheus Panta.
1:41Prometheus Panta: The new gold standard for biologics characterization
Choosing the right stability characterization tool for your biologics research is a big commitment. You’re going to be screening and optimizing lots of candidates, and you’ll need data on thermal stab
38:31nanoDSF for biologics: How to interpret thermal unfolding profiles for your different applications
Thermal stability screening is a common approach used to study the developability of a wide range of protein-based therapeutics. Among the different technologies available to perform thermal stability
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Learn about four methods for thermal stability measurements: DSC, CD, DSF and nanoDSF. You'll review their pros and cons, what they data tell you and why it's important for biologics developability.
The biologics researcher's mini-guide to screening candidates with nanoDSF
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19:07How stability prediction experiments give you confidence in your ADCs
For antibody-drug conjugate (ADC) development, scientists rely on stability experiments using fluorescence and light scattering techniques to predict the conjugated molecule's behavior.
Get predictive insight into your ADC’s stability with these 3 experiments
When developing ADCs, there are some strategies for protein assessment that will help mitigate the risk of destabilizing the final product during early development, particularly when optimizing...
19:16How to mitigate risk during ADC development with multi-parameter stability characterization
To assess the developability properties of antibody-drug conjugates (ADCs) learn about multi-parameter characterization of thermal and colloidal stability with Prometheus Panta using nanoDSF and DLS
De-risk your ADC development process with these stability considerations
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21:31How biologics teams approach developability screening of their candidates with combinatorial stability characterization
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How stability characterization parameters help you create biologics developability profiles
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