Application Notes

Use of self-interaction parameters derived from light scattering experiments for better developability assessment of biologic therapeutics

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Prometheus is a trademark of NanoTemper Technologies GmbH, Munich, Germany. NanoTemper is a registered trademark of NanoTemper Technologies GmbH, Munich, Germany. ©2021 NanoTemper Technologies, Inc. South San Francisco, CA, USA. All Rights Reserved. NT-PR-015 APPLICATION NOTE nanotempertech.com References 1 Hoffman, M. et al. Prediction of Protein Aggregation in High Concentration Protein Solutions Utilizing Protein-Protein Interactions Determined by Low Volume Static Light Scattering. J Pharm Sci. 2016. 2 Bailly, M. et al. Predicting Antibody Developability Profiles Through Early Stage Discovery Screening. mAbs. 2020. 3 Raoufi, F. et al. Stability optimization of engineered mAbs. NanoTemper Technologies application note. 2021. 4 Schramm, P. et al. Sizing accuracy and intra-assay precision of DLS measurements with Prometheus Panta. NanoTemper Technologies technical note. 2020.

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