37
What can r
H
tell me about the shape of my particle?
The r
H
is the absolute size of your particle if it is a sphere. For rod-shaped or
other non-spherical particles, the r
H
will reflect the radius of the longest side.
Beyond absolute size, the r
H
tells you about the relative size of your particle.
It is useful during development to compare the r
H
value for your biologic
in different batches or in different circumstances (e.g., when optimizing
formulation; or when present with a binding partner).
Particle size Particle shape Iconic strength
Solvent-particle interactions
Surface structure
Inter-particle
interactions
Temperature
DLS
r
H
Factors influencing diffusion (and the r
H
)
Viscosity
