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What are some typical r
H
values and how will I know
what the data means?
Generally, r
H
values for monomeric proteins are in the 2-8 nm range. Changes
in r
H
might reflect oligomerization of monomers. Protein complexes start in
the 10-50 nm size range, but can get much larger depending on the complex
in question. Adenovirus, or AAV, which is a common gene therapy vector,
is about 20 nm in radius. As particles get more complex, they tend to get
larger. Viruses and bacteriophages are hundreds of nm in size. Once you are
considering full eukaryotic cells, they are about 1 micron, or 1000 nm in size.
Lysozyme
r
H
=1.9 nm
Glucose
r
H
=0.5 nm
Immunoglobulin G
r
H
=7.1 nm
Bacteriophage
r
H
=100 nm
Cancer cell
r
H
>1 m
P22-VLP
r
H
=55 nm
Smallpox
r
H
=175 nm
