4
What DLS tells you about your biologics
a. Size
b. Sample quality
c. Self-interaction
With a proper understanding of the phenomena
and raw data that comes from DLS, it's time to
dive into the important part-- what parameters
does DLS give you, and how does it help you
make decisions about your candidates? Jump
to this section for a better understanding of how
DLS gives you the power to make better decisions
about your biologics candidates.
4
3
By utilizing the phenomena covered in Section 2,
it is possible to translate the relationship between
particle movement and scattered light intensity into
meaningful data about the size and dispersity of your
biologics candidates. The key to this relationship is the
Autocorrelation Function (ACF), which relates the changes
in light intensity to the molecule's size. Read more about
the ACF and what it tells you about your samples.
Using scattering information to
make measurements
a. Key equation
b. The autocorrelation function
c. Fitting the ACF
d. Fit models
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