Discover how Dianthus solves
4 common problems
Dianthus is a plate-based affinity screening platform that enables you to overcome
the challenges presented by other biophysical methods. Avoid these common
roadblocks with Dianthus and keep your PROTAC projects moving forward.
Stability of your binary complex
is compromised if you have to immobilize it
to study the ternary complex
Measure in solution under controlled
equilibrium conditions, so the binary complex
stays stable when you evaluate
ternary complex affinities
1
It's virtually impossible to be sure you re-
moved a covalent analyte completely from
sensor chips during regeneration
Evaluate molecular interactions in solution in
separate wells, so your affinity assay
is less complicated, stress-free, and more
budget-friendly
2
Measuring affinities with small molecules
like warheads is more difficult with other
affinity methods
Measurements are mass-independent,
so you use Dianthus for primary screening
of fragments, but also to screen for affinity
maturation in PROTAC candidates
3
You only have access to limited amounts
of target and ligands
You'll use less of your target protein, ligase,
and ligands because you'll do less assay
development. And you'll need less once you
start running your affinity assays
4
