Don't give up just yet
when challenging molecules like
these enter your pipeline
Armed with Dianthus, you have an opportunity to remove the
roadblocks you encounter when your hit identification or lead
optimization involves any of these molecules.
PROTACs and other protein degraders
Measuring affinities with small molecules, like warheads,
requires a lot of assay development if your method relies
on significant mass changes to detect a binding event.
And studying the ternary complex gets complicated if
immobilization of the secondary complex is required. With
Dianthus, measurements are done in solution and are
mass-independent — just what your PROTAC screening
project needs.
Intrinsically disordered proteins (IDPs)
Dianthus measures in solution, so the conformational
equilibrium of your IDPs is not at risk of being disrupted
— a common problem with methods that require
immobilization. And because Dianthus uses low target
concentrations, aggregation of the IDPs won't get in the
way of screening for binders.
Fragment libraries
Because fragments are really tiny, identifying hits from
fragment libraries is very difficult with screening methods
that depend on considerable mass changes. Additionally,
you're challenged with measuring weak affinities during
hit identification and tighter affinities when fragments are
grown to form larger compounds. Dianthus overcomes
both issues with mass-independent measurements and an
ability to detect a broad range of affinities.
