NanoTemper Dianthus Brochure

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Hit identification Finding true hits faster is the most important step in making your drug discovery workflow efficient. With Dianthus, you'll find hits quickly and move on to hit validation confidently, whether it's fragment-based or small molecule single-dose screening. Hit validation Spend less time sorting through strong and weak binders. Dianthus generates easy-to-interpret affinity ranking tables and histograms to help you quickly decide on the right candidates and start lead optimization sooner. Screen for hits and optimize leads based on affinity Tackle many projects, not just a few Integrate into any automated solution Harmony in your workflow is so important. Dianthus' 384-well microplate format is compatible with a variety of automation solutions — simply integrate it into your current workflow. Forget about regular maintenance Planning for downtime due to regular maintenance delays your projects. Dianthus is ready whenever you need it — non-stop, 24/7. There's no fluidics, so feel free to turn it on or off whenever you want. Get meaningful results faster at any throughput Dianthus swi ly analyzes 384 data points in 30 minutes and has flexible throughput. Choose to run one sample or as many as you want. Characterize in solution, no immobilization required Analyzing interactions in close-to-native conditions is ideal. Dianthus characterizes in solution, so interfering with your target's binding site or spending on expensive immobilizing chemistries isn't an issue. Evaluate any sample type in any buffer Dianthus isn't picky. Feel free to prep your target in the buffer that ensures its stability and integrity. Even use lysates or bioliquids without diluting them. Consume small amounts of target and compounds Every little bit counts. Saving on costly sample and library compounds means you can do more screening or use them in other projects. Measure affinities with the highest sensitivity Whether strong or weak, Dianthus detects a wide range of binding affinities — picomolar to millimolar — so it's all you need to find your hits. Explore every target, even the most challenging ones There's no end to the projects you can do. Study targets and ligands of any size or mass — from ions to multimeric proteins — and type — proteins, nucleic acids, saccharides, and more.

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