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The scientist's guide to writing successful grant applications

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17 This is the most important part of the proposal. Besides the title, this is the first part the Program Officer reads and can determine who will review it. It's a good idea to make this section stand on its own separately from the rest of the application — it may be the only section that all reviewers on the panel read. If funded, this section could be made available to the public. 3. Specific aims You'll want to start with a brief narrative describing the long-term project goals and show the relevance of your proposal to the PA/RFA. Convey that supporting your project will help the grant agency accomplish its goals. Be sure to include a list of specific research aims — one sentence each — that include a compelling rationale and are related to a common theme, question or idea. Make each aim independent of the others in terms of obtaining suc- cessful outcomes, and make each one broad enough that it involves more than one experiment and conceptually encompasses any alternative outcome if your hypothesis proves invalid. Be logical, brief, and specific. 4. Research strategy or project description Write your research strategy or project description so that it answers the following questions: What are you proposing? Why are you proposing it? How do you plan to do it? Lead the reviewers logically through your research plan by explaining how the proposed research will further what is known. You can emphasize how your novel hypothesis, important preliminary data, new experimental system, or new approach will enable important progress to be made. Include alternative strategies or approaches in case the original ideas fail; you may want to consider alternate hypotheses and explanations. O en times you'll find the following subsections included in the Research Strategy: Significance Here, you'll want to explain the importance of the problem addressed by the project. What is current state of knowledge? What are the strengths and weaknesses of published research or preliminary data? How will your project further the knowledge, technical capabilities, or clinical practice in the field?

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