How to improve the function of your PROTAC degrader by understanding ternary complex formation

In this video, Alessio Ciulli, Ph.D. shows how a PROTAC can “glue” the ligase and the target protein together by forming ternary complexes. He then demonstrates that cooperative, stable, and kinetically long-lived ternary complexes drive faster and more profound protein degradation.

Watch this video to learn the answers to these questions: How do PROTACs work? Why does the ternary complex matter? What defines cooperativity in complex formation? How does ternary complex formation inform rational structure-based drug design? How can ternary complex optimization help overcome challenges with delivering the PROTAC to the cell?

NanoTemper tools are helping researchers characterize interactions involving PROTACs, molecular glues and other TACs.

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