Thermal stability is one of the most common critical quality attribute (CQA) of therapeutic proteins.
Learn about 4 methods for thermal stability assessment of proteins – what they measure, what the data tells you, and their benefits and limitations.
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20:19Developability assessment is a critical part of the evaluation and selection of candidates for further optimization and development for biologics researchers. This work entails collecting, ranking, an
4:51The decisions you make about your biologics candidates early in the pipeline ultimately affect their success as therapeutics. Combine sizing and stability information to develop successful biologics
8:38In this video, Nathan Wallace, Application Specialist at NanoTemper, addresses common questions about experimental design for developability profiling and the operation of Prometheus Panta.
24:28Learn about four methods for thermal stability measurements: DSC, CD, DSF and nanoDSF. You'll review their pros and cons, what they data tell you and why it's important for biologics developability.
Read this nanoDSF guide to learn how nano-Differential Scanning Fluorimetry (nanoDSF) uses your protein’s intrinsic fluorescence to determine its melting temperature, Tm and onset of melting, Ton.
Developability profiles help you avoid risk by collecting many quality attributes associated with each candidate, enabling you to rank each candidate by the most optimal attributes and make a...
21:31Full developability profiles de-risk the selection process for biologics candidates during early development workflows. There are many critical quality attributes to evaluate when it comes to developa
17:33Developability work requires the assessment of multiple critical quality attributes (CQAs) of your biologics. Many of these CQAs are measured or monitored using low-volume, low-concentration samples.
Self-association, or the tendency for a molecule to be attracted to itself, is an important assessment criterium for those concerned about how their biologic will behave in the clinic. Researchers...
Dynamic Light Scattering (DLS) is a versatile and simple tool used for assessing the colloidal stability of drug candidates early in protein-based therapeutic development. Like any tool or...
1:41Choosing the right stability characterization tool for your biologics research is a big commitment. You’re going to be screening and optimizing lots of candidates, and you’ll need data on thermal stab
13:12Watch this 15 min video to learn how groups in early biologics development and formulation use Dynamic Light Scattering (DLS) to make informed decisions that de-risk downstream biologics development.
As a discovery or early development scientist, you’re tasked with identifying the most promising biologics candidates. Your hard work during early development enables straightforward and efficient...
Use this downloadable list of 2023 biologics conferences to select which one to attend. Learn when and where they’ll happen, who’ll be there, and the main focus.
34:16Join this webinar to learn about the physical phenomenon that drives Dynamic Light Scattering (DLS), and see a few examples of how DLS gives you deeper insights.
2:34Discover how 2bind applied multi-parameter characterization from a single experiment to find the optimal buffer for a vaccine antigen target.
