NanoTemper Technologies Launches Dianthus α — Expanding the Power of In-Solution Binding Analysis

NanoTemper Technologies today announced the launch of Dianthus α, an applications package that extends the capabilities of the Dianthus™ system. With Dianthus α, drug discovery teams can now perform assays that were previously out of reach—gaining deeper insights and greater confidence in their binding analyses.

The Dianthus system delivers precise, fast, in-solution binding data using three orthogonal fluorescence-based methods, helping teams accelerate hit-to-lead workflows and tackle hard-to-drug targets. With the new Dianthus α applications package, the platform evolves to include advanced capabilities such as Optical Unfolding, which reveals protein stability, and Slow Kinetics, which resolves long-lived interactions spanning minutes to days.

“The Dianthus α applications package was developed to give discovery teams new ways to evaluate hard-to-drug targets with confidence,” says Eva Lindskog, Chief Commercial Officer at NanoTemper Technologies. “By building on the established power of Spectral Shift technology and introducing Optical Unfolding and Slow Kinetics capabilities, we are giving scientists the clarity to make critical decisions faster. This shows how we continue to reshape what’s possible in drug discovery.”

Advancing the Power of In-Solution Binding Analysis 

• Broaden assay capabilities. Investigate covalent modifications, ternary complexes, and PROTAC assemblies that are often difficult to measure with other approaches.
• Increase confidence in decisions. Support hit confirmation, reduce false positives, and identify potential stability or aggregation issues earlier in the workflow.
• Accelerate discovery. Benefit from low sample use, plate-based assays, and automation options that enable efficient movement from hits to leads.

“The Dianthus α applications package changes how drug discovery teams prioritize and advance their projects,” shares Prateek Joshi, Senior Product Manager at NanoTemper Technologies. “With the ability to detect covalent modifications, measure slow kinetics, and capture complex binding behaviors in solution, we can focus resources on the most promising hits earlier, reduce downstream risk, and drive programs forward more efficiently.”

About NanoTemper Technologies 

NanoTemper Technologies delivers biophysical characterization solutions that simplify complex science—helping researchers and biopharma teams move from data to decisions faster. Co-created with scientists, NanoTemper products empower users to answer more questions, optimize workflows, and proceed with greater confidence in their results. Partnering across industry and academia, NanoTemper supports innovation from discovery through manufacturing—advancing toward a future where every disease is treatable.