MST reveals role of Ubiquitin for regulation of IkB kinase

Scientists from German Research Center for Environmental Health and the Max-Planck-Institute for Biochemistry use MST to reveal the role of different Ubiquitin species for the regulation of IkB kinase (IKK), a gatekeeper of canonical NF-kB signaling:

NEMO interaction with linear and K63 ubiquitin chains contributes to NF-kB activation Hadian et al.,

JBC, DOI: 10.1074/jbc.M111.23316 (2011)