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Ultra-high-throughput biophysical screening of MEK1 using the Dianthus uHTS platform
The Dianthus uHTS platform enables ultra-high-throughput biophysical screening (approx.250 000 data points per day) by detecting ligand interactions using Spectral Shift technology. In this study, we screened 5120 different compounds against MEK1, identifying 62 high priority hits by single dose screening and further 81 hits of a lower...
Binding Affinity Explained
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ebooks & Guides
NanoTemper Technologies announces Dianthus a, an applications package, to push the boundaries
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Biologics
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Whatever aspect of biologics development you’re interested in – antibody engineering, protein-based therapeutic design, formulation, ADC or biosimilar development – there is a resource for you.
Membrane Proteins
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If you’re working with membrane proteins (and losing sleep over it), we’re here to help! Find resources to support your research and finally characterize challenging membrane proteins.
Targeted Protein Degradation
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Explore content on Targeted Protein Degradation, from PROTACs to molecular glues. Learn about ways to efficiently measure binary and ternary complex formation.
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Panel discussion: Breaking barriers in membrane protein drug discovery
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Webinars
Proximity Inducers in Drug Discovery - A Perspective on Cooperativity (2)
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PDF
Enabling Binder and Molecular Glue Discovery with High-Throughput Spectral Shift Technology
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LINK
nanoDSF as an efficient, high-throughput method for ID testing in biologics manufacturing
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NT-PRPC-DataFile-002-2025-DIGITAL
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PDF
Adventures in drug discovery - The quest for your best small molecule
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Latest blogs
Open and FAIR integration: the unglamorous superpower behind faster R&D and being Al-ready.
Read this perspective from Deputy Head of R&D Nathan Adams, on how open and FAIR integration for automatable systems enables efficiency in modern R&D for teams embracing AI/ML assisted research.
Al in Drug Discovery: From Language Models to AlphaFold and Atomically Precise Antibody Design
Discover how Al is transforming drug discovery, from early LLMs and AlphaFold to atomically accurate de novo antibody design, plus how biophysical characterization with NanoTemper accelerates decisions from discovery to manufacturing.
Watch instrument demos
Virtual Monolith X Demo: Free-in-solution affinity measurements with minimal sample consumption
The tool you choose to measure affinities should tackle a diverse range of targets and ligands that come your way — such as GPCRs, IDPs, or cancer-related proteins. And, you should get data that helps you make educated decisions, faster. This is where the Monolith X instrument stands out— as the only way to get binding affinities free in-solution.
Virtual Prometheus Panta demo: Four integrated technologies for protein stability characterization
Your protein stability characterization projects require tools that provide high-precision, high-quality data to support your selection process. To address that requirement, Prometheus Panta offers 4 technologies in one instrument, that deliver the highest quality thermal and colloidal stability data and give you unprecedented insight into your protein’s behavior.
Products
Applications
Solution
Panel discussion: Breaking barriers in membrane protein drug discovery
View more →
Enabling Binder and Molecular Glue Discovery with High-Throughput Spectral Shift Technology
View more →
nanoDSF as an efficient, high-throughput method for ID testing in biologics manufacturing
View more →
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