In this on-demand webinar, Dr. Thorsten Lorenz discusses the developability assessment strategy used at Novartis in their biologics pipeline and how they apply high-throughput stability testing to pre-formulation using NanoTemper’s Prometheus system.
Predicting the behavior of these molecules in terms of stability, aggregation, viscosity, immunogenicity is vital for evaluating potential risks and making better-educated decisions. Assessing the “developability” of new biologics helps you select the optimal candidates for advancing from discovery to development.
Knowing as much as possible, early on about candidate molecules is important to avoid failures at a more costly time point.
Around 90% of all biotherapeutic candidates fail during clinical development stages. If preclinical stages are included, this number rises to nearly 99%. Lack of desirable physicochemical attributes, low efficacy, and unacceptable toxicity are some of the biggest hurdles researchers face. So, what can be done to improve the chances of a candidate becoming a drug?