Application Notes

Ultra-high-throughput biophysical screening of MEK1 using the Dianthus uHTS platform

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2 2 A P P L I C A T I O N N O T E [10] W. P. Janzen, "Screening technologies for small molecule discovery: The state of the art," Sep. 18, 2014, Elsevier Ltd. doi: 10.1016/j.chembiol.2014.07.015. [11] L. M. Mayr and P. Fuerst, "The Future of High-Throughput Screening," SLAS-DISCOVERY, vol. 13, pp. 443–448, 2008, doi: 10.1177/1087057108319644. [12] A. A. Adjei, "The Role of Mitogen-Activated ERK-Kinase Inhibitors in Lung Cancer Therapy," Clin Lung Cancer, vol. 7, no. 3, pp. 221–223, Nov. 2005, doi: 10.3816/CLC.2005.n.040. [13] N. Malo, J. A. Hanley, S. Cerquozzi, J. Pelletier, and R. Nadon, "Statistical practice in high-throughput screening data analysis," Nature Biotechnology 2006 24:2, vol. 24, no. 2, pp. 167–175, Feb. 2006, doi: 10.1038/nbt1186. [14] A. N., S. C., and T. Che, "Data Analysis Approaches in High Throughput Screening," in Drug Discovery, InTech, 2013. doi: 10.5772/52508. [15] "Streamlit • A faster way to build and share data apps." Accessed: Mar. 14, 2025. [Online]. Available: https:// streamlit.io/ [16] "Python.org." Accessed: Mar. 14, 2025. [Online]. Available: https://www.python.org / [17] Franck Maddoux, "Enabling ultra-high throughput biophysical direct binding measurement in the 1536-well plate format," in Society for Laboratory Automation and Standardization, San Diego, Jan. 2025. © 2025 NanoTemper Technologies, GmbH, Munich, Germany. All Rights Reserved.

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