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Analyzing binding affinity can get complicated, so you may
even need to consider adopting multiple technologies to
tackle your research. You could, for example, use a faster
technology that requires little sample to pre-screen all your
molecules of interest, and then use a slow, more complex
method to further study only those molecules that looked
promising in your pre-screen.
The approach of using a faster, less complicated technology
first saves you time, effort and money and allows you to focus
on the most relevant targets that will further your research.
How do I evaluate
vendors?
Vendors who offer technologies for measuring binding
affinity provide a lot of information about their product
offerings on their websites or in sales collateral such
as catalogs, brochures, and videos. Find answers to
fundamental questions about the capabilities of the
platform you are considering by browsing the product
specifications and features, such as whether the instrument
works with your type of sample, the size of the system's
footprint, and what consumables are required for its use.
Vendors by technology
(In alphabetical order)
B I O L A Y E R I N T E R F E R O M E T R Y ( B L I )
Sartorius, offers Octet devices
sartorius.org
Gator Bio
gatorbio.com
I S O T H E R M A L T I T R A T I O N C A L O R I M E T R Y ( I T C )
Malvern Panalytical,
offers MicroCal instruments
malvernpanalytical.com
T E M P E R A T U R - R E L A T E D I N T E N S I T Y C H A N G E ( T R I C )
NanoTemper Technologies,
offers Monolith
nanotempertech.com
S P E C T R A L S H I F T
NanoTemper Technologies,
offers Monolith and Dianthus
nanotempertech.com
S U R F A C E P L A S M O N R E S O N A N C E ( S P R )
Cytiva, offers the Biacore series
cytivalifesciences.com
Carterra
carterra-bio.com
Sartorius
sartorius.com
