17
Surface Plasmon
Resonance
(SPR)
Isothermal
Titration
Calorimetry
(ITC)
BioLayer
Interferometry
(BLI)
Temperature
Related Intensity
Change
(TRIC)
Spectral
Shi
Sample consumption Medium High Medium Low Low
Requires a fluorescent tag No No No Optional Yes
Requires surface immobilization Yes No Yes No No
High throughput Yes No Yes No Yes
Easy to use No No Yes Yes Yes
Instrument costs High Low Medium Medium Medium
Consumable costs High Low Medium Medium Medium
Measures binding kinetics Yes No Yes No No
Overview of technologies
