The common thread to perform a meaningful stability
assessment? Exemplary data quality and resolution are
required when you need to discern even the slightest
variation between candidates for better decision-making.
With high-quality data about your biologics' thermal stability,
the subtle differences between constructs and conditions
are unveiled, making your selection process faster, more
straightforward, and all around less of a headache.
Conclusion
With T
m
s and T
on
s determined from high-resolution
nanoDSF data, it is possible to narrow down your pipeline
more efficiently, no matter what kind of biologics
experiment you're working on. Information derived
from the thermal unfolding profiles of your candidates
enables you to rank the best candidates for
developability.
This guide introduced some different experiments in bio-
logics, and what to look for in the nanoDSF-derived thermal
stability profiles for each.
